Results 81 to 90 of about 340,216 (285)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
OPPOSITIONAL REPRESENTATION OF DERIVATIONAL RELATIONS: A METALANGUAGE POTENTIAL
Вестник Волгоградского государственного университета: Серия 2. Языкознание, 2017 The theoretical problem of language meta-description is considered with the support of oppositionality concept – an important feature of language system-forming relations.
Aleksandr A. Barkovich
doaj +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
A long-wave action of spin Hamiltonians and the inverse problem of the calculus of variations
, 2003 We suggest a method of derivation of the long-wave action of the model spin Hamiltonians using the non-linear partial differential equations of motions of the individual spins.
A.S. Ovchinnikov +11 more
core +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Geodesic Equations on Diffeomorphism Groups
Symmetry, Integrability and Geometry: Methods and Applications, 2008 We bring together those systems of hydrodynamical type that can be written as geodesic equations on diffeomorphism groups or on extensions of diffeomorphism groups with right invariant $L^2$ or $H^1% metrics.
Cornelia Vizman
doaj +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Information Structure Projects in Syntax: Evidence from Focus and Modality in Sinhala
Crossroads, 2018 The major claim of this paper is that information structure related particles of Sinhala are distinct functional heads and they project in syntax. This is in line with the cartographic approach to syntax which claims that discourse related features are ...
M.G. Lalith Ananda
doaj +1 more source