Results 81 to 90 of about 338,726 (289)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Geodesic Equations on Diffeomorphism Groups

Symmetry, Integrability and Geometry: Methods and Applications, 2008
We bring together those systems of hydrodynamical type that can be written as geodesic equations on diffeomorphism groups or on extensions of diffeomorphism groups with right invariant $L^2$ or $H^1% metrics.
Cornelia Vizman
doaj   +1 more source

A family tree of Markov models in systems biology

, 2007
Motivated by applications in systems biology, we seek a probabilistic framework based on Markov processes to represent intracellular processes. We review the formal relationships between different stochastic models referred to in the systems biology ...
Alfonsi, Blomberg, Cao, Cao, Doob, Dublanche, Elf, Elf, Elf, Elf, Ellis, Gillespie, Gillespie, Grima, Haseltine, Kepler, Kholodenko, Kramers, Lipniacki, M. Ullah, Metzler, O. Wolkenhauer, Paszek, Paszek, Paulsson, Paulsson, Rao, Saxton, Saxton, Schnell, Singer, Wolkenhauer, Wolkenhauer, Wolkenhauer   +33 more
core   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Formal derivation of a new sediment transport model using a multiscale procedure: Numerical Validation

Partial Differential Equations in Applied Mathematics
We study in this work structures formed under a unidirectional flow. The main problem that addresses sediment transport by aquatic flow. We present the formal derivation of a new sediment transport model by using a multiscale procedure in time and space.
Julien Zongo, Jean De Dieu Zabsonre, Brahima Roamba   +2 more
doaj   +1 more source

The Generalized SIC-OEP formalism and the Generalized SIC-Slater approximation (stationary and time-dependent cases)

, 2010
We present a generalized formulation of the Optimized Effective Potential (OEP) approach to the Self Interaction Correction (SIC) problem in Time Dependent (TD) Density Functional Theory (DFT).
Abdurahman, Bianchetti, Blum, Calvayrac, Calvayrac, Champagne, Diep, Edmiston, Fermi, Foster, Goedecker, Goedecker, Gross, Guan, Hohenberg, Hybertsen, Kohn, Kohn, Korzdorfer, Korzdorfer, Krieger, Krieger, Kümmel, Kümmel, Kümmel, Kümmel, Lauritsch, Legrand, Levy, Marques, Messud, Messud, Messud, Messud, Messud, Mundt, Nieminen, Pacheco, Pederson, Pederson, Pemmaraju, Perdew, Perdew, Perdew, Perdew, Polo, Reinhard, Runge, Sharp, Talman, Tong, Tong, Ullrich, van Faassen, van Gisbergen, van Gisbergen, van Leeuwen, Vignale, Vignale, von Barth, Vydrov   +60 more
core   +3 more sources

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

The Sagnac Phase Shift suggested by the Aharonov-Bohm effect for relativistic matter beams

, 2003
The phase shift due to the Sagnac Effect, for relativistic matter beams counter-propagating in a rotating interferometer, is deduced on the bases of a a formal analogy with the the Aharonov-Bohm effect.
A. A. Michelson, A. A. Michelson, B. Mashhoon, C. Cattaneo, C. Cattaneo, C. Cattaneo, C. Cattaneo, C. Cattaneo, C. W. Misner, D. Dieks, D. K. Atwood, E. J. Post, F. Goy, F. Hasselbach, F. Riehle, F. Selleri, F. Selleri, F. W. Hehl, G. B. Malykin, G. E. Stedman, G. Rizzi, G. Rizzi, Guido Rizzi, J. Anandan, J. Croca, J. E. Zimmermann, J. J. Sakurai, J. J. Sakurai, J. P. Vigier, M. G. Sagnac, M. G. Sagnac, Matteo Luca Ruggiero, O. J. Lodge, O. J. Lodge, P. Harzer, P. K. Anastasowksi, P. Tourrenc, R. Anderson, R. Arnowitt, R. T. Jantzen, S. A. Werner, S. Bergia, T. A. Weber, W. A. Rodrigues Jr., W. W. Chow, Y. Aharonov   +45 more
core   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Coboundary Lie bialgebras and commutative subalgebras of universal enveloping algebras [PDF]

, 2005
We solve a functional version of the problem of twist quantization of a coboundary Lie bialgebra (g,r,Z). We derive from this the following results: (a) the formal Poisson manifolds g^* and G^* are isomorphic; (b) we construct a subalgebra of U(g ...
Enriquez, B., Halbout, G.
core   +1 more source