Results 31 to 40 of about 674,793 (310)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Development of Smart Link Book as a Medium for Interaction Between Special School Institutions and Parents Through User Centered Design [PDF]

E3S Web of Conferences
By redesigning linking books, this study seeks to enhance the user-communication experience (UX) between school-aged children with special needs (SLB) and their parents.
Listyaningrum R. Anggia, Nur Hidayat Wahyu, Ediyanto, Nur Iswara Luthansyah, Dicky Maulana Irwanto Lalu, Wahiza Binti Abdul Wahat Nor   +5 more
doaj   +1 more source

The role and importance of internship programs as part of formal education: Students' perceptions: The case of college of tourism [PDF]

Turističko Poslovanje, 2017
As one of the fastest growing industries tourism is in increasing need for well educated and skillful employees on both operational and managerial level.
Šimičević Dario, Štetić Snežana
doaj   +1 more source

Formal – Non-formal – Informal in Education

Procedia - Social and Behavioral Sciences, 2013
AbstractTherefore, an opening of school activity is required, in the direction of combining formal strategies, which are specific to class, with non-formal and informal strategies, outside the class or school's perimeter and the forming use of elements offered by various educational environments.
openaire   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

The Community Empowerment Through Social and Educational Institutions

Jurnal Pendidikan Humaniora, 2018
: The purpose of this study is to explore the role of social and educational institutions in Bajulmati in the process of community empowerment. This research uses a qualitative approach.
Bayu Adi Laksono
doaj  

Concepciones acerca de la maternidad en la educación formal y no formal

Actualidades Investigativas en Educación, 2005
Este artículo presenta algunos resultados de la investigación desarrollada en el Instituto de Investigación en Educación (INIE), bajo el nombre: "Construcción del concepto de maternidad en la educación formal y no formal".
Kathia Alvarado Calderón
doaj   +1 more source

Integration of Video Games in Teaching and Learning at School: Use, Analyze, Make-create

Vilnius University Open Series, 2020
This article aims to reveal different ways of integrating video games, and emerging challenges in Lithuanian schools. The integration of computer games is exposed by selecting the project Big Small Screens.
Gintė Marija Ivanauskienė
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Managing Formal, Non-Formal and Informal Economic Education [PDF]

Revista de Management Comparat International, 2013
If we consider how to effectively deal with economic education, we should start with the questions that entrepreneurs ask themselves when they start a business. Their goal is to make it profitable.
Monica Elisabeta PĂDURARU
doaj