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The interphase of the formalin test
Pain, 2014The formalin test still surprises with its biphasic pain-related behavior resulting from a quiescent interphase that does not occur with other algogenic compounds and remains unexplained. The first phase has been attributed to TRPA1-mediated excitation of nociceptors, the second phase to their inflammatory and/or spinal sensitization.
Michael, Fischer +3 more
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Neuroscience & Biobehavioral Reviews, 2004
The subcutaneous injection of formalin into the rat upper lip generates behavioral responses that last several minutes. The time course of the response is similar to what is observed following formalin injection into the paw, i.e. biphasic, with an early and short-lasting first phase followed, after a quiescent period by a second, prolonged (tonic ...
Patrick, Raboisson, Radhouane, Dallel
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The subcutaneous injection of formalin into the rat upper lip generates behavioral responses that last several minutes. The time course of the response is similar to what is observed following formalin injection into the paw, i.e. biphasic, with an early and short-lasting first phase followed, after a quiescent period by a second, prolonged (tonic ...
Patrick, Raboisson, Radhouane, Dallel
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The formalin test: Effects of formalin concentration and short-term halothane inhalation
Regional Anesthesia and Pain Medicine, 2001In order to evaluate the effects of formalin concentration and inhalational anesthetics in formalin tests, we injected 5 concentrations of formalin into awake and anesthetized rats and investigated their behavior and the c-fos immunoreactivity of their spinal cords.Sixty adult male Sprague-Dawley rats were divided into 10 experimental groups.
T, Fukuda +3 more
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Formalin: Nephrotoxic teratogen?
Journal of Obstetrics and Gynaecology Research, 2010AbstractFormaldehyde is an extensively used chemical; its ill effects have been of concern. Its nephrotoxic effects in laboratory animals and carcinogenic effects on humans are well established. We report of a pregnant woman with a normal ongoing pregnancy with a morphologically normal fetus.
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The orofacial formalin test in rats: effects of different formalin concentrations
Pain, 1995In this study of the orofacial formalin test in rats, the effects of different formalin concentrations (0.2%, 0.5%, 1.5%, 2.5%, 5% and 10%) on the behavioural nociceptive response (face rubbing) was investigated. The histological responses of the skin were also evaluated.
Pierre, Clavelou +4 more
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The Renal Response to Formalinization
Urologia Internationalis, 2010Dilute solutions of formalin, surgically injected under direct vision into the cortex of the mouse kidney is soon attended by degeneration and necrosis of the proximal convoluted tubules for a distance around the injection site. After 4 weeks, regeneration and some attempt at repair become evident in the epithelium.
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New Zealand Veterinary Journal, 1983
Changes in formalin concentration were measured over time in uncontaminated solutions and solutions heavily contaminated by mud, faeces, wool or straw. Shallow plastic trays containing 1.11 of a 9% aqueous solution of formalin were exposed for 6 days (trial 1) or 8 days (trial 2) to windy autumn weather. Evaporation of solution volumes was high (47-73%)
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Changes in formalin concentration were measured over time in uncontaminated solutions and solutions heavily contaminated by mud, faeces, wool or straw. Shallow plastic trays containing 1.11 of a 9% aqueous solution of formalin were exposed for 6 days (trial 1) or 8 days (trial 2) to windy autumn weather. Evaporation of solution volumes was high (47-73%)
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The formalin test: an evaluation of the method
Pain, 1992A. Tjølsen +4 more
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Archives of Dermatology, 1981
To the Editor.— In the article entitled "Cutaneous Endosalpingiosis" by Dore et al in the August 1980Archives(116:909-212), they stated that "the specimens were fixed in a 10% formaldehyde solution." Did the authors mean to say 10% formalin? Ten percent formalin is the standard fixative used in modern histopathology.
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To the Editor.— In the article entitled "Cutaneous Endosalpingiosis" by Dore et al in the August 1980Archives(116:909-212), they stated that "the specimens were fixed in a 10% formaldehyde solution." Did the authors mean to say 10% formalin? Ten percent formalin is the standard fixative used in modern histopathology.
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