Results 31 to 40 of about 426,896 (244)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Accidental local infiltration of formalin into the buccal mucosa: A case report and review of the literature

Clinics and Practice, 2018
Formalin is a hazardous chemical, yet it is the choice of fixative for diagnostic pathology. Dental surgeons routinely use formalin for preservation of oral biopsy specimens. Literature search revealed that during regular biopsy procedures, unintentional
Sachin C. Sarode, Gargi S. Sarode, Yashwant Ingale, Manjusha Ingale, Mahesh Chavan, Nilesh Patil, Barnali Majumdar, Prashant Kumar, Shankargouda Patil   +8 more
doaj   +1 more source

Alat Pendeteksi Formalin Menggunakan Deret Sensor HCHO dan MQ-7 dengan Logika Fuzzy

Jurnal Nasional Teknik Elektro dan Teknologi Informasi, 2023
Formalin merupakan zat kimia berbahaya yang memiliki bau menyengat, tidak memiliki warna atau jernih, dan mudah terbakar. Formalin, yang seharusnya digunakan untuk bahan pengawet mayat, banyak disalahgunakan oleh oknum pedagang, salah satunya untuk ...
Cyntiya Laxmi Haura, Indri Yanti, Muh Pauzan   +2 more
doaj   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Life Cycle Assessment of The Formalin Production Process Using Methods Eco-indicator 99, IMPACT 2002+, EDIP 2003 [PDF]

Journal of Chemical and Petroleum Engineering
Life cycle assessment is a suitable tool to examine and measure of the environmental aspects of the production of a product from the beginning to its formation. In this study, the environmental impacts of the production process of 1 ton of formalin in an
Leila Taghizadeh Isini, Mohsen Ghanatghestani, Nargess Kargari, Saber Ghasemi   +3 more
doaj   +1 more source

UJI FORMALIN PADA TAHU YANG DI PERDAGANGKAN DI CIPUTAT TANGERANG SELATAN

Dalton, 2022
Tahu merupakan makanan yang sering dikonsumsi masyarakat Indonesia yang berbahan dasar kacang kedelai. Tahu mengandung protein tinggi sehingga mudah rusak dan tidak tahan lama sehingga tak jarang ditambahkan bahan pengawet seperti formalin.
Nita Rosita
doaj   +1 more source

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Use of Formalin-Preserved Collections to Infer Trophic Indicators of Marine Zooplankton from Stable Isotopes

Diversity, 2023
Formalin preservation affects the stable isotope composition of zooplankton samples, thus limiting the analysis of valuable collections covering large time intervals.
Antonio Bode, Jaime Otero, Ángel F. Lamas, Carmen Mompeán   +3 more
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source