Results 51 to 60 of about 107,416 (241)

Cardiovascular Exercise Drives Neuroprotection in a Mouse Model of Spinocerebellar Ataxia 1 Via Rescue of Aberrant Splicing

Annals of Neurology, EarlyView.
Objective Spinocerebellar ataxia 1 (SCA1) is a fatal hereditary neurodegenerative disorder with no approved therapies, and gene‐targeting strategies have thus far failed in clinical trials. Exercise remains the only intervention shown to provide clinical benefit in patients with spinocerebellar ataxias (SCAs), yet the underlying mechanisms remain ...
Isabel Soto, Michael Bonomo, Brianna S. Nelthrope, Benjamin D. Carr, Emma Palmer, Mariana Sierra, Ilkim Erturk, David Peppercorn, Eleonor Cox, Tiare K. Vasconcellos, Henry L. Paulson, Hannah K. Shorrock, Sharan R. Srinivasan   +12 more
wiley   +1 more source

Modeling formamide denaturation of probe-target hybrids for improved microarray probe design in microbial diagnostics.

PLoS ONE, 2012
Application of high-density microarrays to the diagnostic analysis of microbial communities is challenged by the optimization of oligonucleotide probe sensitivity and specificity, as it is generally unfeasible to experimentally test thousands of probes ...
L Safak Yilmaz, Alexander Loy, Erik S Wright, Michael Wagner, Daniel R Noguera   +4 more
doaj   +1 more source

Durch anomere Amide ermöglichte divergente Synthese unsymmetrischer Harnstoffe, Carbamate, Thioester und Amide aus Aldehyden

Angewandte Chemie, EarlyView.
Eine divergente Aldehyd‐Funktionalisierungssequenz, ermöglicht durch ein anomeres Amid, erlaubt den Ein‐Topf‐Zugang zu unsymmetrischen Harnstoffen, Carbamaten, Thiocarbamaten, Thioestern und Amiden. Entscheidend für diese Transformation ist die Bildung von N‐Boc‐Hydroxamat‐Intermediaten, die als Plattformen für eine orthogonale Aktivierung über Lossen ...
Jasper L. Tyler, Meiyi Zeng, Julius Wiener, Marie‐Christin Leusmann, Colin Stein, Constantin G. Daniliuc, Frank Glorius   +6 more
wiley   +1 more source

Manganese(II) and Zinc(II) metal complexes of novel bidentate formamide-based Schiff base ligand: synthesis, structural characterization, antioxidant, antibacterial, and in-silico molecular docking study

Frontiers in Chemistry
A new bidentate Schiff base ligand (C16H16Cl2N4), condensation product of ethylene diamine and 4-chloro N-phenyl formamide, and its metal complexes [M(C16H16Cl2N4)2(OAc)2] (where M = Mn(II) and Zn(II)) were synthesized and characterized using various ...
Vijay Kumar Juyal, Shweta Chand Thakuri, Mohit Panwar, Rashmi, Om Prakash, Kahkashan Perveen, Najat A. Bukhari, Viveka Nand   +7 more
doaj   +1 more source

N-[3-(2-Methylphenyl)isoquinolin-1-yl]formamide

Acta Crystallographica Section E, 2009
The title compound, C17H14N2O, crystallizes as a cis formamide isomer. The isoquinoline and benzene fragments are nearly perpendicular [dihedral angle = 81.79 (18)°], whereas the formamide group is virtually coplanar with the ...
Qing Bao Song, Xiao Li Chen, Jun Qi Li, Fu Na Cui   +3 more
doaj   +1 more source

Anomeric Amide Enabled Divergent Synthesis of Unsymmetrical Ureas, Carbamates, Thioesters, and Amides From Aldehydes

Angewandte Chemie International Edition, EarlyView.
An anomeric amide‐enabled divergent aldehyde functionalization sequence provides one‐pot access to unsymmetrical ureas, carbamates, thiocarbamates, thioesters, and amides. Key to this transformation is the formation of N‐Boc‐hydroxamate intermediates, which serve as platforms for orthogonal activation via Lossen‐type rearrangements, single‐electron ...
Jasper L. Tyler, Meiyi Zeng, Julius Wiener, Marie‐Christin Leusmann, Colin Stein, Constantin G. Daniliuc, Frank Glorius   +6 more
wiley   +1 more source

Reactions of 1-Alkyl-3-phenylbenzimidazolium Salts with Ag₂O: The Formation of a Ring-Opening Formamide Derivative and a Ag Complex with an N-heterocyclic Carbene Ligand

Inorganics
This study investigated the reactions of 1-alkyl-3-phenylbenzimidazolium salts with Ag2O. It was found that the selectivity of the reaction products was influenced by the N-alkyl substituent on the azolium ring.
Satoshi Sakaguchi, Takashi Higashino, Yudai Tasaki, Ryo Ichihara, Tatsuo Yajima   +4 more
doaj   +1 more source

Phosphorylation of Milkweed Fibers With a Phosphate Ester: Effect on Fiber Properties and Optimization of Reaction Conditions

Journal of Applied Polymer Science, EarlyView.
The phosphorylation of milkweed fibers using the phosphate ester/urea system was optimized. The impact of reaction temperature, duration, and phosphate ester ratio on the efficiency of phosphorylation was investigated using the design of experiments approach.
Ahmed Azrrar, François Brouillette, Zahahe Oulame Mouandhoime, Saïd Elkoun, Mathieu Robert   +4 more
wiley   +1 more source

Novel Thermoplastic Natural Down Powder Film with High Mechanical Properties

Chemical Engineering Transactions, 2017
Superfine down powder was modified by formamide which acts as a plasticizer and then hot-pressed into thermoplastic down films. The influences of formamide content, hot-pressing time, pressure intensity and exposure to atmosphere on the mechanical ...
Ke Zhang, Kai Yang, Pei Lv, Wenbin Li
doaj   +1 more source

Molecular methods for differentiating Phragmites australis subspecies and identification of hybrid stands in the Upper Midwestern United States

Applications in Plant Sciences, EarlyView.
Abstract Premise In North America, Phragmites australis (common reed) has drawn a great deal of research attention. Non‐native P. australis subsp. australis is a noxious weed that has locally displaced native P. australis subsp. americanus in some areas.
Nicholas P. Tippery, Daniel J. Larkin, Julia Bohnen, Douglas L. Wendell, Neil O. Anderson, Susan M. Galatowitsch, Marie Abbey, Alan G. Smith, Andrzej K. Noyszewski   +8 more
wiley   +1 more source