Results 81 to 90 of about 15,156,703 (244)
Analyse d'une formation plurilingue à distance : actions et interactions
ALSIC: Apprentissage des Langues et Systèmes d'Information et de Communication, 2006 This paper focuses on analysing three sessions of cross-comprehension training in romance languages which took place using similar scenarii on the e-learning platform "Galanet"."Galanet" learning schemes assemble large groups of students (from one to two
Jean-Jacques Quintin, Monica Masperi
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Dans les cours à distance autorythmés : la difficulté de communiquer [PDF]
, 2014 Parce qu’en formation à distance, l’isolement est la cause de beaucoup d’abandons (Bernard et al., 2004; Elliott et al., 2005), nous avons tenté d’augmenter la perception de présence transactionnelle, c’est-à-dire le degré auquel un étudiant en formation
Poellhuber, Bruno +5 more
core +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Actes du Colloque sur la formation à distance tenu à Mirabel du 25 au 28 mai 1982
, 1982 La couv. porte en outre: Colloque québécois 1982 : tour d'horizon, l'utilisation pédagogique, la formation à distance au Québec, les structures d'organisationNotes bibliogr.
Colloque sur la formation à distance (1982 : Mirabel, Québec) +2 more
core +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Revue internationale des technologies en pédagogie universitaire, 2021 Cathia Papi +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology
Molecular Oncology, EarlyView.This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic +15 more
wiley +1 more source