Results 231 to 240 of about 254,330 (298)

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Development of a patient-reported outcomes registry for patients with brain tumours (BEACON). [PDF]

ESMO Real World Data Digit Oncol
Sanderson E, Campbell AB, Drummond K, Dumas M, Johns J, Harold M, Gibbs P, Gately L.   +7 more
europepmc   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Correction: Additional Investigations and Referrals by Primary Care Physicians in Uncertain Clinical Situations: Cross-Sectional Study Using Virtual Patient-Based Scenarios. [PDF]

JMIR Form Res
Lorenzo M, Pelaccia T, Triby E, Can Y, Krider R, Maisonneuve H, Fernandez N.   +6 more
europepmc   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Development and Evaluation of the Joseph-RATA (Rubrics Ask-Tell-Ask) Structured Feedback Model in Undergraduate Pharmacology. [PDF]

Cureus
Joseph G, Bhatti N, Badyal DK, Oberoi A, Kumar A.   +4 more
europepmc   +1 more source

AI-Assisted Formative Assessment in Clinical Education: From Algorithms to Agency. [PDF]

JMIR Med Educ
Nguyen QT, Ha TM, Mai T.
europepmc   +1 more source

Feasibility of Privacy-preserving Locally Hosted Language Models for Assessing Medical Student Reflective Writing. [PDF]

Med Sci Educ
Rejeleene R, Byram JN, Frankel RM, Isaacson JH, Mehta NB.   +4 more
europepmc   +1 more source