Results 101 to 110 of about 347,436 (311)
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Osteological remains of condors from the Late Formative Cerro Punta Blanca, Lorin Valley, Peru.
Revista do Museu de Arqueologia e Etnologia, 2012 In 2007 we found same partial skeletal remains of two Andean condors with evidence of cut marks and fractures postmortem in archaeological context of lime exploitation during the Late Formative period, at the site of Cerro Punta Blanca (300-100 b.C ...
Alfredo José Altamirano Enciso +1 more
doaj +1 more source
Review of State Policies on Teacher Induction [PDF]
, 2012 Outlines criteria and recommendations for state policies on providing mentoring support for new teachers and administrators, including universality, program standards on design and operation, mentor quality, program delivery, funding, and ...
Dara Barlin +3 more
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Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
On Demand: Exploring the Potential of Electronic Feedback on Assessment Performance [PDF]
, 2016 This paper presents the findings from an evaluatory pedagogical project that utilised an ethnographic case study approach to examine factors influencing the use of online formative assessment and feedback within an undergraduate programme.
Daley-Yates, Sue +2 more
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Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
An investigation into the use of e-assessment to support student learning [PDF]
, 2009 Interactive computer-marked assessment has been incorporated into a range of science courses at the UK Open University. Different question types have been used, but all allow students multiple attempts so as to enable them to act on the feedback provided.
Jordan, Sally
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Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source