Results 101 to 110 of about 46,757 (308)

Machalilla revisited - New data for the Early Formative Period of Coastal Ecuador

, 2023
In 2017, the German Archaeological Institute (DAI) initiated a joint project with the Pontificia Universidad Católica del Ecuador, Quito (PUCE), to study the Machalilla culture, a cultural expression from the Ecuadorian coast that belongs to the ...
Dyrdahl, Eric, Ugalde, Fernanda, Prümers, Heiko   +2 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Harmonic weak Maass forms and periods II [PDF]

Mathematische Annalen
AbstractIn this paper we investigate the Fourier coefficients of harmonic Maass forms of negative half-integral weight. We relate the algebraicity of these coefficients to the algebraicity of the coefficients of certain canonical meromorphic modular forms of positive even weight with poles at Heegner divisors.
Alfes-Neumann, Claudia, Bruinier, Jan Hendrik, Schwagenscheidt, Markus   +2 more
openaire   +5 more sources

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

A Web-Based Alcohol Risk Communication Tool: Development and Pretesting Study

, 2020
Background: Alcohol use is a major public health concern associated with an increased risk of morbidity and mortality. Health professionals in primary care commonly see patients with a range of alcohol-related risks and problems, providing an ideal ...
Dobson, Rosie, Sharpe, S, Humphrey, Gayle, Kool, Bridget, Whittaker, R, Ameratunga, Shanthi   +5 more
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Crocodilians and Olmecs: Further Interpretations in Formative Period Iconography

, 1980
An ecological approach to religion is utilized to examine crocodilians represented in highland and lowland Mesoamerican art from the Early Formative to European contact.
Stocker, Terry, Armsey, Steve, Meltzoff, Sarah   +2 more
core   +1 more source

Period Mapping Associated to a Primitive Form

Publications of the Research Institute for Mathematical Sciences, 1983
The author gives a summary of the study of Gauss-Manin connection of a Hamiltonian system, higher residue pairing, primitive forms and period mapping associated with a universal unfolding of an isolated hypersurface singularity. As recent developments in the subject, he shows how to reduce the existence of primitive forms to the existence of certain ...
openaire   +3 more sources

Periodic twists of $GL_3$-automorphic forms

, 2019
We prove that sums of length about q3/2 of Hecke eigenvalues of automorphic forms on SL3(Z) do not correlate with q-periodic functions with bounded Fourier transform. This generalizes the earlier results of Munshi and Holowinsky–Nelson, corresponding to multiplicative Dirichlet characters, and applies, in particular, to trace functions of small ...
Kowalski, Emmanuel, Lin, Yongxiao, Michel, Philippe, Sawin, Will   +3 more
openaire   +3 more sources