Results 121 to 130 of about 46,757 (308)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Valdivia an early formative culture of Ecuador
, 1958 AS knowledge of the early pottery-making cultures in the New World has expanded, it has become increasingly evident that widely separated regions were influenced by a common source. Similarities in vessel shape, surface finish and technique of decoration
Evans, Clifford, Meggers, Betty
core
, 2012 The notion of a formative power is one of the most obscure in Kant’s theory of biology. In section I of the paper, I will provide a list of all passages in which Kant uses the term, claiming that the older meaning of ‘formative power’ in Kant’s writings ...
Goy, Ina
core +1 more source
Bianchi modular forms and the rationality of periods
Canadian Mathematical BulletinAbstract Using an explicit Eichler–Shimura–Harder isomorphism, we establish the analog of Manin’s rationality theorem for Bianchi periods and hence special values of L -functions of Bianchi cusp forms. This gives a new short proof of a result of Hida in the case of Euclidean
Gradin Anderson +4 more
openaire +2 more sources
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Scientific ReportsFor many years, the rise of stratified societies along the Central Andean coast, known as the birthplace of Andean civilization, has been closely linked to a marine-oriented economy.
Luis Pezo-Lanfranco +1 more
doaj +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Professional Development through formative assessment
, 2014 Since the extensive research overview on formative assessment by Black and Wiliam (1998) it has been clear that formative assessment can lead to great improvements in students' learning.
Nyberg, Eva,
core
PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines
FEBS Open Bio, EarlyView.Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart +7 more
wiley +1 more source
FEBS Open Bio, EarlyView.We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa +2 more
wiley +1 more source