Results 111 to 120 of about 46,757 (308)
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Estudios AtacameñosDentro del conjunto de bienes que circularon en los Andes Centro-Sur se encuentran los moluscos o restos malacológicos, tanto completos como modificados (p.e. cuentas de collar y pendientes).
Catalina Soto Rodríguez
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Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Rediscovering the landmark New Zealand plays: The formative period of New Zealand drama, 1948-1970
, 2013 Available to authenticated members of The University of Auckland.This thesis examines New Zealand drama from 1948 to 1970, specifically New Zealand plays (written by local writers, for local audiences) staged within this period.
Wenley, James
core
, 2015 International audienceNorthern Chile’s Atacama Desert is one of the most unforgiving landscapes on the planet; however, a variety of complex risk-mitigation strategies facilitated long-term human occupation of the region.
Gallardo, Francisco +9 more
core +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Closed Geodesics and Periods of Automorphic Forms
Advances in Mathematics, 2001 Let \(\gamma\) be a prime closed geodesic on a compact hyperbolic surface of genus \(g\) uniformized by \(\Gamma< \text{PSL} (2,\mathbb{R})\), and \(\ell(\gamma)\) be its length, while \([\gamma]\) is its homology class \(H_1(\mathbb{H}/ \Gamma,\mathbb{Z})\). Further, let \(\pi(T,\alpha):= \#\{\gamma: l(\gamma)\leq T\), \([\gamma]= \alpha\}\). From the
openaire +1 more source