Results 121 to 130 of about 1,630,631 (307)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Limit-Forms of Time

Critical Hermeneutics
To establish what time is, as in Plato’s iconic definition (“moving image of eternity”, Timaeus 37d), one often has to emphasize its relation to what time is not. Time seems to be defined dialectically, in terms of what is not eternal, not extra-temporal, etc.
openaire   +3 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Phase Estimation from Atom Position Measurements

, 2010
We study the measurement of the position of atoms as a means to estimate the relative phase between two Bose-Einstein condensates. First, we consider $N$ atoms released from a double-well trap, forming an interference pattern, and show that a simple ...
A Smerzi, F Piazza, Grond J, Grond J Hohenester U Schmiedmayer J Smerzi A, Heine D, Helstrom C W, Holevo A S, J Chwedeńczuk, Mach E   +8 more
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Statistics of gamma-ray point sources below the Fermi detection limit

, 2011
An analytic relation between the statistics of photons in pixels and the number counts of multi-photon point sources is used to constrain the distribution of gamma-ray point sources below the Fermi detection limit at energies above 1 GeV and at latitudes
Abazajian, Abdo, Abdo, Abdo, Angelakis, Atwood, Ave, Berrington, David W. Hogg, Dmitry Malyshev, Dobler, Faucher-Giguère, Fields, Geringer-Sameth, Górski, Hasinger, Hensley, Hodge, Hoel, Hopkins, Li, Malyshev, Miyaji, Neronov, Padovani, Padovani, Pavlidou, Scheuer, Smolčić, Sołtan, Stecker, Strong, Thompson   +32 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

STUDY THE EFFECTS OF PRESTRAINS IN UNIAXIAL TENSION ON THE FORMING LIMIT DIAGRAM OF ALUMINUM ALLOY SHEETS(2024 T3)

Tikrit Journal of Engineering Sciences, 2015
          The strain path for sheet metal may be changed during forming , this may be affect the forming limit curve (FLC) . In this work the FLC before and after prestraining was determined for aluminum alloy (2024 T3) to study the effect of this type ...
Waleed J. Ali, Thaer F. Ahmed
doaj  

Effects of the roller feed ratio on wrinkling failure in conventional spinning of a cylindrical cup

, 2011
In this study, wrinkling failure in conventional spinning of a cylindrical cup has been investigated by using both finite element (FE) analysis and experimental methods.
Ashley, D, Long, H, Roberts, M, Wang, L, White, P   +4 more
core   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source