Results 71 to 80 of about 366,377 (310)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Aproximação inversa e otimização topológica aplicados à determinação de leiaute de Tailored Blanks [PDF]

open access: yes, 2007
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Engenharia MecânicaOs blanks soldados ou tailored blanks consistem de peças de aços de diferentes espessuras, classes de resistência ou ...
Silveira, Márcio Eduardo
core  

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Forming limit curves and forming limit stress curves for advanced high strength steels

open access: yes, 2018
Experimental and numerical investigations using Forming Limit Curve (FLC) and Forming Limit Stress Curve (FLSC) were carried out for two Advanced High Strength Steel (AHSS) grades DP780 and TRIP780. The forming limit curves were experimentally determined
Barlat, F   +4 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Finite element assisted prediction of ductile fracture in sheet bulging of magnesium alloys [PDF]

open access: yes, 2008
There is currently a growing demand for energy efficiency, particularly in reducing the rate of oil consumption. One solution in this area is for the aerospace and automotive industries to produce lighter vehicles that are more fuel efficient.
Hunt, David
core  

Effects of layer arrangement, pin size, polyurethane thickness, and polyurethane hardness on forming limits of Al/Cu bimetallic sheets through multi-point forming process

open access: yesJournal of Materials Research and Technology
This study experimentally evaluated the forming limit diagram (FLD) of Al/Cu bimetallic sheets fabricated using explosive welding in multi-point forming.
Milad Aali Majidabad   +2 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

The analysis of forming limit in re-penetration process of the hole-flanging of sheet metal

open access: yes, 2011
A methodology for formulating an elasto-plastic finite element model was developed to analyze the direct penetration and re-penetration in the hole-flanging process.
Li, Ching-Lun; Huang, You-Min; Tsai, Yi-Wei
core   +1 more source

Home - About - Disclaimer - Privacy