Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Sheet metal forming limit predictions based on advanced constitutive equations
, 2019 The present paper aims at analysing the strain and stress-based forming limits predicted by an advanced sheet metal forming limit model. The onset of localized necking is simulated through the Marciniak-Kuczinsky (MK) analysis [1]., which connects the ...
Barlat, F +3 more
core +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Analysis of forming limits in metal forming processes
, 2011 Forming limit plays a very important role in metal forming processes since it can be used to predict whether a blank will fracture or not. This paper examines the influence on forming limit of blank and fractured thickness.
Li, Ching-Lun; Huang, Y.-M.; Tsai, Y.-W.; Li, C.-L. +1 more
core +1 more source
Application of the continuum shell finite element SHB8PS to sheet forming simulation using an extended large strain anisotropic elastic–plastic formulation [PDF]
, 2012 http://link.springer.com/article/10.1007%2Fs00419-012-0620-xThis paper proposes an extension of the SHB8PS solid–shell finite element to large strain anisotropic elasto-plasticity, with application to several non-linear benchmark tests including sheet ...
BALAN, Tudor +3 more
core +1 more source
Unsupervised Deep Learning for Advanced Forming Limit Analysis in Sheet Metal: A Tensile Test-Based Approach. [PDF]
Materials (Basel), 2023 Thamm A +5 more
europepmc +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Enhancing/Improving Forming Limit Curve and Fracture Height Predictions in the Single-Point Incremental Forming of Al1050 Sheet Material. [PDF]
Materials (Basel), 2023 Hoang TK, Luyen TT, Nguyen DT.
europepmc +1 more source
MetalsIn the belt-heated incremental sheet forming process, the influence of process parameters on the forming limit angle significantly affects the forming accuracy and quality of components.
Zhengyuan Gao +9 more
doaj +1 more source
Forming limit of hot-rolled high-strength steels considering sheet thickness effect [PDF]
MATEC Web of ConferencesThe forming limit curve (FLC) has been commonly used tool to predict the metal forming cracking in engineering. Whereas, based on the assumption of plane stress state, the formability prediction of thick sheet of hot-rolled high-strength steels is quite ...
Zhang Shi-Hong +4 more
doaj +1 more source