Results 61 to 70 of about 2,936,466 (288)
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
MetalsThe experimental determination of Forming Limit Curves, standardized by ISO 12004-2 and ASTM E2218, remains the conventional framework for evaluating sheet metal formability, whereas the Small Punch Test, supported by ASTM E3205, has traditionally ...
Erik López Vargas +8 more
doaj +1 more source
Thickness Scaling of Forming Limit Curves
Solid State PhenomenaA consistent kinematic method was developed to calculate a forming limit curve (FLC) for a material with thickness t * 0 from a given FLC pertaining to a different thickness t 0 ≠ t * 0
openaire +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Comparison of forming limit diagrams predicted with different localization criteria [PDF]
, 2008 Automotive industries are more and more subject to restrictive environmental constraints. Weight reduction of structures seems to be an interesting way to satisfy these requirements.
ALTMEYER, Guillaume +2 more
core
, 2010 International audienceThe main objective of this work is to propose a new experimental device able to give for a single specimen a good prediction of rheological parameters and formability under static and dynamic conditions (for intermediate strain ...
Ragneau, Eric +3 more
core +1 more source
Journal of Manufacturing and Materials ProcessingIn recent decades, the automotive industry has faced challenges around improving energy efficiency, reducing pollutant emissions, increasing occupant safety, and reducing production costs.
Rafael Guetter Bohatch +4 more
doaj +1 more source
Formulation of Forming Load in V-Bending
MATEC Web of Conferences, 2016 A novel method is described to calculate the forming load in V-bending by a press brake. The data of forming load are collected by FEM analysis. With an increase of the punch stroke in V-bending, the forming load increases gradually after the elastic ...
Koumura Yuki, Wang Zhigang
doaj +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source