Results 71 to 80 of about 484,909 (306)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Effects of layer arrangement, pin size, polyurethane thickness, and polyurethane hardness on forming limits of Al/Cu bimetallic sheets through multi-point forming process

Journal of Materials Research and Technology
This study experimentally evaluated the forming limit diagram (FLD) of Al/Cu bimetallic sheets fabricated using explosive welding in multi-point forming.
Milad Aali Majidabad, Ramin Hashemi, Habibolah Akbari   +2 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Determination of the forming limit diagram of zinc electro-galvanized steel sheets

Metalurgija, 2012
Forming limit curves (FLC) of deep drawing steel sheets have been determined experimentally and calculated on the base of the material tensile properties following the Hill, Swift, Marciniak-Kuczyński and Sing-Rao methods.
W. Fracz, F. Stachowicz
doaj  

The importance of the deformation necks in forming [PDF]

, 2012
Cílem této bakalářské práce je vypracování rešerše na téma deformační sítě v oblasti tváření. V práci jsou popsány jednotlivé metody nanášení sítí. Jsou zhodnoceny jejich výhody a nevýhody a využití v praxi. Mimoto je provedeno srovnání nejpoužívanějších
Kučera, Radek
core  

Infalling groups and galaxy transformations in the cluster A2142

, 2017
We study galaxy populations and search for possible merging substructures in the rich galaxy cluster A2142. Normal mixture modelling revealed in A2142 several infalling galaxy groups and subclusters.
Deshev, Boris, Einasto, Jaan, Einasto, Maret, Gramann, Mirt, Heinämäki, Pekka, Kipper, Rain, Lietzen, Heidi, Park, Changbom, Saar, Enn, Tempel, Elmo   +9 more
core   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

The Establishment of Surface Roughness as Failure Criterion of Al–Li Alloy Stretch-Forming Process

Metals, 2016
Taking Al–Li–S4–T8 Al–Li alloy as the study object, based on the stretching and deforming characteristics of sheet metals, this paper proposes a new approach of critical orange peel state characterizations on the basis of the precise measurement of ...
Jing-Wen Feng, Li-Hua Zhan, Ying-Ge Yang
doaj   +1 more source

A Spitzer IRAC Census of the Asymptotic Giant Branch Populations in Local Group Dwarfs. II. IC 1613

, 2007
We present Spitzer Space Telescope IRAC photometry of the Local Group dwarf irregular galaxy IC 1613. We compare our 3.6, 4.5, 5.8, and 8.0 micron photometry with broadband optical photometry and find that the optical data do not detect 43% and ...
Charles E. Woodward, Dale C. Jackson, Elisha Polomski, Evan D. Skillman, Robert D. Gehrz, Udalski A., van Loon J. T., van Loon J. T., Volders L. M. J. S., Wolf M.   +9 more
core   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source