Results 71 to 80 of about 487,180 (307)

An in-plane tensile test for rheological and formability identification : comparison between experimental and numerical FLC

, 2011
International audienceBoth accurate constitutive laws and formability limits of materials are essential for a numerical optimization of sheet forming processes. To identify these behaviors, experimental databases are needed. In this work, experiments are
Guines, Dominique, Leotoing, Lionel, Ragneau, Eric   +2 more
core   +2 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Insight into the Influence of Punch Velocity and Thickness on Forming Limit Diagrams of AA 6061 Sheets—Numerical and Experimental Analyses

Metals, 2021
In this article, the forming limit diagram (FLD) for aluminum 6061 sheets of thicknesses of 1 mm and 3 mm was determined numerically and experimentally, considering different punch velocities.
Sasan Sattarpanah Karganroudi, Shahab Shojaei, Ramin Hashemi, Davood Rahmatabadi, Sahar Jamalian, Ahmad Aminzadeh, Hussein Ibrahim   +6 more
doaj   +1 more source

Experimental and Numerical Investigations of Deep Drawability of AA1200 [PDF]

, 2016
The ability of a sheet metal to be formed in a given process without failure is known as formability. Formability is a measure of the amount of deformation a material can withstand prior to fracture or excessive thinning. Forming Limit Diagram (FLD) is a
Ahlawat, A. (Amit), Gautam, M. V. (Mr), Jain, S. (Sumit), Kumar, M. (Manoj)   +3 more
core  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

The methanol lines and hot core of OMC2-FIR4, an intermediate-mass protostar, with Herschel/HIFI [PDF]

, 2010
In contrast with numerous studies on the physical and chemical structure of low- and high-mass protostars, much less is known about their intermediate-mass counterparts, a class of objects that could help to elucidate the mechanisms of star formation on ...
Bell, T., Blake, G. A., Boogert, A., Kama, M., Lis, D., Lord, S., Phillips, T. G.   +6 more
core  

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Circumstellar Disks in the Outer Galaxy: the Star-Forming Region NGC 1893 [PDF]

, 2008
It is still debated whether star formation process depends on environment. In particular it is yet unclear whether star formation in the outer Galaxy, where the environmental conditions are, theoretically, less conducive, occurs in the same way as in the
Caramazza, M., Micela, G., Prisinzano, L., Rebull, L., Sciortino, S., Stauffer, J. R.   +5 more
core   +3 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source