Results 191 to 200 of about 12,229,065 (261)

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Study of Properties of Composite Cementitious Materials with Sulfoaluminate Cement and Solid Waste Based on Compaction Forming Process. [PDF]

Materials (Basel)
Ma Z, Wang X, Yu M, Chen S, Liu J, Li J, Wang J, Sun H, Mao Y, Hu Z, Wang W.   +10 more
europepmc   +1 more source

Understanding Effects of Ultrasonic Vibration on Microstructure Evolution in Hot Forming Process via Cellular Automata Method. [PDF]

Materials (Basel), 2022
Zhang Y, Zhou W, Tang J, He Y.
europepmc   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Characterization of Hexagonal Close-Packed Zn-Cu-Ti Alloy Pyramid Drawpieces in Single-Point Incremental Sheet Forming Process. [PDF]

Materials (Basel)
Kuczek Ł, Żaba K, Trzepieciński T, Balcerzak M, Novák V.   +4 more
europepmc   +1 more source

Minimizing the Main Strains and Thickness Reduction in the Single Point Incremental Forming Process of Polyamide and High-Density Polyethylene Sheets. [PDF]

Materials (Basel), 2023
Rosca N, Oleksik M, Rosca L, Avrigean E, Trzepieciński T, Najm SM, Oleksik V.   +6 more
europepmc   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

A Deformational Analysis of a Titanium Alloy Supported by the Mathematical Modelling of the Sheet Metal Forming Process via Numerical Simulation. [PDF]

Materials (Basel)
Koreček D, Solfronk P, Sobotka J.
europepmc   +1 more source

Multistage Tool Path Optimisation of Single-Point Incremental Forming Process. [PDF]

Materials (Basel), 2021
Yan Z, Hassanin H, El-Sayed MA, Eldessouky HM, Djuansjah J, A Alsaleh N, Essa K, Ahmadein M.   +7 more
europepmc   +1 more source

Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix

FEBS Letters, EarlyView.
The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual, Marta Navarro‐Gutiérrez, Verónica Romero‐Albillo, Raquel Jiménez‐Sánchez   +3 more
wiley   +1 more source