Results 61 to 70 of about 5,879,381 (333)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Evanescent-Light Deposition of Graphene Onto Tapered Fibers for Passive Q-Switch and Mode-Locker

IEEE Photonics Journal, 2012
We demonstrate the fabrication of graphene-deposited tapered fibers (GDTFs), which can be used as saturable absorbers (SAs) for pulsed lasers. The advantages of GDTF SAs include flexibility, all-fiber configuration, and high optical damage threshold. The
Jinzhang Wang, Zhengqian Luo, Min Zhou, Chenchun Ye, Hongyan Fu, Zhiping Cai, Huihui Cheng, Huiying Xu, Wei Qi   +8 more
doaj   +1 more source

Multiplicity Formula and Stable Trace Formula [PDF]

American Journal of Mathematics, 2019
Let $G$ be a connected reductive group over $\mathbb{Q}$. In this paper, we will stabilize the local trace formula, in particular, we construct the explicit form of the spectral side of stable local trace formula in the Archimedean case, when one component of the test function is cuspidal.
openaire   +2 more sources

Products of two proportional primes

, 2017
In RSA cryptography numbers of the form [Formula: see text], with [Formula: see text] and [Formula: see text] two distinct proportional primes play an important role.
Moree, P., Saad Eddin, S.
core   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

A Numerical Model for Studying Multimicrochip and Single-Chip LEDs With an Interdigitated Mesa Geometry

IEEE Photonics Journal, 2013
A 3-D numerical model has been developed to investigate the transient thermal, electrical, and optical output performance of a single-chip light-emitting diode (LED) with an interdigitated mesa geometry under dc operation and a multimicrochip LED under ...
Farn-Shiun Hwu, Ti-Hsiang Sung, Chun-Hung Chen, Jia-Wei Tseng, Heng Qiu, Jyh-Chen Chen   +5 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Analytical Expression of Average Power-Coupling Coefficients for Estimating Intercore Crosstalk in Multicore Fibers

IEEE Photonics Journal, 2012
In order to realize fast and accurate estimation of intercore crosstalk in bent multicore fibers (MCFs), an analytical expression of the average power-coupling coefficient (PCC) based on an exponential autocorrelation function is, for the first time ...
Masanori Koshiba, Kunimasa Saitoh, Katsuhiro Takenaga, Shoichiro Matsuo   +3 more
doaj   +1 more source

Measurement of WZ and ZZ production in pp collisions at [Formula: see text] in final states with b-tagged jets. [PDF]

, 2014
Measurements are reported of the WZ and ZZ production cross sections in proton-proton collisions at [Formula: see text][Formula: see text] in final states where one Z boson decays to b-tagged jets.
Adam, W, Adler, V, Alderweireldt, S, Bansal, M, Bansal, S, Beernaert, K, Benucci, L, Bergauer, T, Blekman, F, Blyweert, S, Caillol, C, Chatrchyan, S, Cimmino, A, Clerbaux, B, CMS Collaboration, Cornelis, T, Costantini, S, Crucy, S, D'Hondt, J, De Lentdecker, G, De Wolf, EA, Dildick, S, Dragicevic, M, Erö, J, Fabjan, C, Favart, L, Friedl, M, Frühwirth, R, Garcia, G, Gay, APR, Ghete, VM, Hartl, C, Heracleous, N, Hrubec, J, Hörmann, N, Janssen, X, Jeitler, M, Kalogeropoulos, A, Keaveney, J, Khachatryan, V, Kiesenhofer, W, Kim, TJ, Klein, B, Knutsson, A, Knünz, V, Krammer, M, Krätschmer, I, Lellouch, J, Liko, D, Lowette, S, Luyckx, S, Léonard, A, Maes, M, Marage, PE, Mccartin, J, Mikulec, I, Mohammadi, A, Mossolov, V, Ocampo Rios, AA, Ochesanu, S, Olbrechts, A, Perniè, L, Rabady, D, Rahbaran, B, Reis, T, Rohringer, H, Roland, B, Rougny, R, Ryckbosch, D, Salva Diblen, S, Schöfbeck, R, Seva, T, Shumeiko, N, Sigamani, M, Sirunyan, AM, Strauss, J, Strobbe, N, Strom, D, Suarez Gonzalez, J, Taurok, A, Tavernier, S, Thomas, L, Thyssen, F, Treberer-Treberspurg, W, Tumasyan, A, Tytgat, M, Van Doninck, W, Van Haevermaet, H, Van Mechelen, P, Van Mulders, P, Van Onsem, GP, Van Remortel, N, Van Spilbeeck, A, Vander Velde, C, Vanlaer, P, Villella, I, Walsh, S, Waltenberger, W, Wang, J, Wulz, C-E   +99 more
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source