Results 61 to 70 of about 4,752,483 (291)

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Optical Retroreflective Marker Fabricated on Silicon-On-Insulator

IEEE Photonics Journal, 2011
Optical retroreflective markers provide a strong return signal when illuminated by a source, resulting in an easy way to localize and identify an object.
K. Van Acoleyen, D. C. O'Brien, F. Payne, W. Bogaerts, R. Baets   +4 more
doaj   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Mid-Infrared Grating Couplers for Silicon-on-Sapphire Waveguides

IEEE Photonics Journal, 2012
Theoretical and experimental results of mid-infrared (mid-IR) gratings for coupling between transverse-electric (TE)/transverse-magnetic (TM) mode silicon-on-sapphire (SOS) waveguides and zirconium, barium, lanthanum, aluminum, and sodium fluoride (ZBLAN)
Zhenzhou Cheng, Xia Chen, C. Y. Wong, Ke Xu, Christy K. Y. Fung, Y. M. Chen, Hon Ki Tsang   +6 more
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

TWDM-PON With Signal Remodulation and Rayleigh Noise Circumvention for NG-PON2

IEEE Photonics Journal, 2013
We propose and demonstrate a 40-Gb/s (4 × 10 Gb/s) downstream and 10-Gb/s (4 × 2.5 Gb/s) upstream time-wavelength-division-multiplexed passive optical network (TWDM-PON) using signal remodulation. Here, a downstream differential-phase-shift-
C. W. Chow, C. H. Yeh, K. Xu, J. Y. Sung, H. K. Tsang   +4 more
doaj   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

A Simple Transfer-Function-Based Approach for Estimating Material Parameters From Terahertz Time-Domain Data

IEEE Photonics Journal, 2014
A novel parametrically efficient approach to estimating the spectra of short transient signals is proposed and evaluated, with an application to estimating material properties, including complex refractive index and absorption coefficient, in the ...
K. M. Tych, C. D. Wood, W. Tych
doaj   +1 more source

Measurement of WZ and ZZ production in pp collisions at [Formula: see text] in final states with b-tagged jets. [PDF]

, 2014
Measurements are reported of the WZ and ZZ production cross sections in proton-proton collisions at [Formula: see text][Formula: see text] in final states where one Z boson decays to b-tagged jets.
Adam, W, Adler, V, Alderweireldt, S, Bansal, M, Bansal, S, Beernaert, K, Benucci, L, Bergauer, T, Blekman, F, Blyweert, S, Caillol, C, Chatrchyan, S, Cimmino, A, Clerbaux, B, CMS Collaboration, Cornelis, T, Costantini, S, Crucy, S, D'Hondt, J, De Lentdecker, G, De Wolf, EA, Dildick, S, Dragicevic, M, Erö, J, Fabjan, C, Favart, L, Friedl, M, Frühwirth, R, Garcia, G, Gay, APR, Ghete, VM, Hartl, C, Heracleous, N, Hrubec, J, Hörmann, N, Janssen, X, Jeitler, M, Kalogeropoulos, A, Keaveney, J, Khachatryan, V, Kiesenhofer, W, Kim, TJ, Klein, B, Knutsson, A, Knünz, V, Krammer, M, Krätschmer, I, Lellouch, J, Liko, D, Lowette, S, Luyckx, S, Léonard, A, Maes, M, Marage, PE, Mccartin, J, Mikulec, I, Mohammadi, A, Mossolov, V, Ocampo Rios, AA, Ochesanu, S, Olbrechts, A, Perniè, L, Rabady, D, Rahbaran, B, Reis, T, Rohringer, H, Roland, B, Rougny, R, Ryckbosch, D, Salva Diblen, S, Schöfbeck, R, Seva, T, Shumeiko, N, Sigamani, M, Sirunyan, AM, Strauss, J, Strobbe, N, Strom, D, Suarez Gonzalez, J, Taurok, A, Tavernier, S, Thomas, L, Thyssen, F, Treberer-Treberspurg, W, Tumasyan, A, Tytgat, M, Van Doninck, W, Van Haevermaet, H, Van Mechelen, P, Van Mulders, P, Van Onsem, GP, Van Remortel, N, Van Spilbeeck, A, Vander Velde, C, Vanlaer, P, Villella, I, Walsh, S, Waltenberger, W, Wang, J, Wulz, C-E   +99 more
core  

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source