Keratinocyte-neutrophil interactions revealed as targetable drivers of sustained inflammation in Sweet syndrome. [PDF]
Tahara U, Amagai M.
europepmc +1 more source
Formyl Peptide Receptor-2-Suppressed Autophagy Promotes the Migration and Invasion of Human Glioblastoma Cells Through PI3K/Akt Signaling. [PDF]
Luo Z +5 more
europepmc +1 more source
TRPC6 effects on albumin permeation, nephrin shedding, and apoptosis in podocytes: Role of calcineurin and metalloproteases. [PDF]
Kim EY, Dryer SE.
europepmc +1 more source
Monoclonal Antibody 5F1 Modulates Formyl Peptide Receptor 1 Conformation for Transmembrane Signaling. [PDF]
Wang Y, Liu Y, Chang Y, Ye RD.
europepmc +1 more source
Transdermal Delivery of Hyaluronate-Conjugated Formyl Peptide Receptor 2 Agonistic Peptide Ameliorates Bleomycin-Induced Skin Fibrosis. [PDF]
Park GT +8 more
europepmc +1 more source
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Formyl-peptide receptors revisited
Trends in Immunology, 2002Leukocytes accumulate at sites of inflammation and microbial infection in direct response to locally produced chemotactic factors, which signal through specific G protein-coupled receptors. The first chemotactic factors to be structurally defined were the N-formyl peptides. Unlike other leukocyte chemoattractants, N-formyl peptides could originate from
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Pleiotropic roles of formyl peptide receptors
Cytokine & Growth Factor Reviews, 2001FPR and FPRL1 belong to the seven-transmembrane, G protein-coupled chemoattractant receptor superfamily. Because of their capacity to interact with bacterial chemotactic formylated peptides, these receptors are thought to play a role in host defense against microbial infection.
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Role of Formyl Peptide Receptors in Gastrointestinal Healing
Current Pharmaceutical Design, 2018The wound healing and the barrier restoration of the gastrointestinal (GI) mucosa must be continuously ensured to allow homeostasis of the gastrointestinal tract and of all the surrounding tissues. Several lines of the evidence report a key role of innate immunity, and in particular of Pattern Recognition Receptors (PRRs), in controlling the ...
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