Results 1 to 10 of about 9,630 (179)
Promiscuous Receptors and Neuroinflammation: The Formyl Peptide Class
Life, 2022 Formyl peptide receptors, abbreviated as FPRs in humans, are G-protein coupled receptors (GPCRs) mainly found in mammalian leukocytes. However, they are also expressed in cell types crucial for homeostatic brain regulation, including microglia and blood ...
Edward S. Wickstead +2 more
doaj +7 more sources
The N-formyl peptide receptors: much more than chemoattractant receptors. Relevance in health and disease [PDF]
Frontiers in ImmunologyPattern Recognition Receptors (PRRs) are a superfamily of receptors that detect molecular structures typical for pathogens and damaged cells and play a crucial role in the proper function of the innate immune system.
Filomena Napolitano +2 more
doaj +4 more sources
Bioactive Compounds as Modulators of N-Formyl Peptide Signaling in Chronic Diseases [PDF]
MoleculesIn physiological situations involving cell damage, molecules derived from mitochondria or bacteria are produced. These molecules are known as N-formyl peptides and are detected by formyl peptide receptors (FPRs), which stimulate immune cells to migrate ...
Livia Alvarenga +5 more
doaj +2 more sources
Cross‐Platform Biosensing of Immune Receptors Using Peptide‐Functionalized Graphene [PDF]
Advanced ScienceChanges in the composition of specific cell‐surface molecules on immune cells are important early markers of directed immune responses. Current biosensors largely focus on detecting soluble disease markers.
Ahmar Hasnain +5 more
doaj +2 more sources
Assessing the potential of bacterial signal peptides for radiopharmaceutical applications [PDF]
Scientific ReportsBacterial signal peptides are a large group of high-affinity ligands for formyl peptide receptors (FPRs). These receptors are highly enriched on the surface of glioblastomas and several other tumor types.
Zukaa Al Taleb +5 more
doaj +2 more sources
Frontiers in Immunology, 2021 Non-responsiveness to anti-TNF-α therapies presents relevant rates in inflammatory bowel disease patients, presenting the need to find biomarkers involved in therapeutic efficacy.
Marina de Paula-Silva +10 more
doaj +1 more source
NEW FORMYL PEPTIDE HAS THE STIMULATING PROPERTIES IN POINT OF IMMUNE SYSTEM CELLS [PDF]
Annals of Mechnikov's Institute, 2017 Introduction Tuberculosis infection (TBI) is still one of the major health problems, despite of global intensive medical and pharmaceutical efforts as it is known, in the majority of immunocompetent individuals TBI is repressed by immune system, and as a
Martynov A. V. +6 more
doaj +1 more source
FITC Conjugation Markedly Enhances Hepatic Clearance of N-Formyl Peptides. [PDF]
PLoS ONE, 2016 In both septic and aseptic inflammation, N-formyl peptides may enter the circulation and induce a systemic inflammatory response syndrome similar to that observed during septic shock.
Cristina Ionica Øie +4 more
doaj +1 more source
Life, 2022 Formyl peptide receptor type 2 (FPR2/ALX) belongs to the formyl peptide receptors (FPRs) family clustered on chromosome 19 and encodes a family of three Class A of G protein-coupled receptors (GPCRs).
Mariantonella Colucci +5 more
doaj +1 more source
The role of the host—Neutrophil biology
Periodontology 2000, EarlyView., 2023 Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple +4 more
wiley +1 more source