Results 21 to 30 of about 9,630 (179)

Cytochalasin B triggers a novel pertussis toxin sensitive pathway in TNF-alpha primed neutrophils

BMC Cell Biology, 2004
Background Cytochalasin B does not directly activate the oxygen-radical-producing NADPH oxidase activity of neutrophils but transfers desensitized G-protein coupled receptors (GPCR) into an active signaling state by uncoupling GCPR from the cytoskeleton.
Mellqvist Ulf-Henrik, Fu Huamei, Pellmé Sara, Bylund Johan, Hellstrand Kristoffer, Karlsson Anna, Dahlgren Claes   +6 more
doaj   +1 more source

Biased perspectives on formyl peptide receptors

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2019
The innate immune system is the first line of defense against pathogenic threats. For the early pathogen recognition and activation of cell protective mechanisms, germline-encoded pattern recognition receptors (PRRs) detect characteristic and evolutionary conserved pathogen-associated molecular patterns (PAMPs).
Carsten Alexander Raabe, Jieny Gröper, Ursula Rescher   +2 more
openaire   +2 more sources

The Formyl Peptide Receptors: Diversity of Ligands and Mechanism for Recognition

Molecules, 2017
The formyl peptide receptors (FPRs) are G protein-coupled receptors that transduce chemotactic signals in phagocytes and mediate host-defense as well as inflammatory responses including cell adhesion, directed migration, granule release and superoxide ...
Hui-Qiong He, Richard D. Ye
doaj   +1 more source

Formyl peptide receptor as a novel therapeutic target for anxiety-related disorders. [PDF]

PLoS ONE, 2014
Formyl peptide receptors (FPR) belong to a family of sensors of the immune system that detect microbe-associated molecules and inform various cellular and sensorial mechanisms to the presence of pathogens in the host.
Irene Gallo, Lorenza Rattazzi, Giuseppa Piras, Thomas Gobbetti, Elisabetta Panza, Mauro Perretti, Jeffrey W Dalley, Fulvio D'Acquisto   +7 more
doaj   +1 more source

Pyridinone Derivatives as Interesting Formyl Peptide Receptor (FPR) Agonists for the Treatment of Rheumatoid Arthritis

Molecules, 2021
Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by joint inflammation, cartilage damage and bone destruction. Although the pharmacological treatment of RA has evolved over the last few years, the new drugs have serious side ...
Letizia Crocetti, Claudia Vergelli, Gabriella Guerrini, Maria Paola Giovannoni, Liliya N. Kirpotina, Andrei I. Khlebnikov, Carla Ghelardini, Lorenzo Di Cesare Mannelli, Elena Lucarini, Igor A. Schepetkin, Mark T. Quinn   +10 more
doaj   +1 more source

Formyl Peptide Receptor 1 and 2 Dual Agonist Inhibits Human Neutrophil Chemotaxis by the Induction of Chemoattractant Receptor Cross-desensitization

Journal of Pharmacological Sciences, 2011
Formyl peptide receptor 1 (FPR1) and FPR2/ALX are known to control neutrophil chemotaxis in response to various ligands. In this study, we investigated the inhibitory mechanism of compound 43 (Cpd43), an FPR1 and FPR2/ALX dual agonist, on human ...
Yoshitaka Sogawa, Takao Ohyama, Hiroaki Maeda, Kazuki Hirahara   +3 more
doaj   +1 more source

Preservation of Post-Infarction Cardiac Structure and Function via Long-Term Oral Formyl Peptide Receptor Agonist Treatment

JACC: Basic to Translational Science, 2019
Summary: Dysregulated inflammation following myocardial infarction (MI) promotes left ventricular (LV) remodeling and loss of function. Targeting inflammation resolution by activating formyl peptide receptors (FPRs) may limit adverse remodeling and ...
Ricardo A. García, PhD, Bruce R. Ito, PhD, John A. Lupisella, MSc, Nancy A. Carson, BSc, Mei-Yin Hsu, MSc, Gayani Fernando, MSc, Madeleine Heroux, PhD, Michel Bouvier, PhD, Elizabeth Dierks, PhD, Ellen K. Kick, PhD, David A. Gordon, PhD, Jian Chen, PhD, Gabe Mintier, BSc, Marilyn Carrier, PhD, Stéphane St-Onge, MSc, Himanshu Shah, MSc, Jordan Towne, BSc, Marcela Sotelo Bucardo, BSc, Xiuying Ma, PhD, Carol S. Ryan, BSc, Nicholas R. Wurtz, PhD, Jacek Ostrowski, PhD, Francisco J. Villarreal, MD, PhD   +22 more
doaj   +1 more source

Structural Requirements for Molecular Recognition by fMLP Analogs Receptors: Comparative Conformational Analysis of (for-Met-Leu-Phe- OMe) and its Thioamide Analog (for-Met-Leuψ[CSNH]Phe-OMe)

Acta Chimica Slovenica, 2018
In order to determine the structural requirements of fMLP analogs receptors, this work presents the results of a comparative conformational analysis of the active chemotactic peptide (formyl-Met-Leu-Phe-OMe) and its inactive analog (formyl-Met-Leuψ [CSNH]
Chakib Ameziane Hassani, Mourad Houssat, Jamal Eddine Hazm, Ahmed Harrach   +3 more
doaj   +1 more source

Regulation of Inflammation and Oxidative Stress by Formyl Peptide Receptors in Cardiovascular Disease Progression

Life, 2021
G protein-coupled receptors (GPCRs) are the most important regulators of cardiac function and are commonly targeted for medical therapeutics. Formyl-Peptide Receptors (FPRs) are members of the GPCR superfamily and play an emerging role in cardiovascular ...
Valentina Maria Caso, Valentina Manzo, Tiziana Pecchillo Cimmino, Valeria Conti, Pio Caso, Gabriella Esposito, Vincenzo Russo, Amelia Filippelli, Rosario Ammendola, Fabio Cattaneo   +9 more
doaj   +1 more source

Expression and Signaling of Formyl-Peptide Receptors in the Brain

Neurochemical Research, 2010
The human formyl-peptide receptor (FPR) and its variants FPRL1 and FPRL2 belong to the G-protein coupled seven transmembrane receptor (GPCR) family sensitive to pertussis toxin. FPR and FPRL1 were first detected in phagocytic leukocytes, and FPRL2 was found in monocytes and in dendritic cells.
CATTANEO, FABIO, GUERRA, GERMANO, AMMENDOLA, ROSARIO   +2 more
openaire   +3 more sources