Results 1 to 10 of about 11,842 (181)

Formyl peptide receptor-1 (FPR1) represses intestinal oncogenesis [PDF]

OncoImmunology, 2023
Formyl peptide receptor-1 (FPR1) is a pattern recognition receptor that is mostly expressed by myeloid cells. In patients with colorectal cancer (CRC), a loss-of-function polymorphism (rs867228) in the gene coding for FPR1 has been associated with ...
Julie Le Naour, Léa Montégut, Yuhong Pan, Sarah Adriana Scuderi, Pierre Cordier, Adrien Joseph, Allan Sauvat, Valerio Iebba, Juliette Paillet, Gladys Ferrere, Ludivine Brechard, Claire Mulot, Grégory Dubourg, Laurence Zitvogel, Jonathan G. Pol, Erika Vacchelli, Pierre-Laurent Puig, Guido Kroemer   +17 more
doaj   +2 more sources

Inhibition of formyl peptide receptor-1-mediated cell death as a therapy for lethal cutaneous drug reactions in preclinical models [PDF]

Nature Communications
Stevens-Johnson syndrome and toxic epidermal necrolysis are life-threatening mucocutaneous adverse drug reactions characterized by disseminated skin and mucosal detachment.
Haruna Kimura, Akito Hasegawa, Tomoki Nishiguchi, Hong Ha Nguyen, Masatoshi Eguchi, Manao Kinoshita, Youichi Ogawa, Takeaki Ozawa, Riichiro Abe   +8 more
doaj   +2 more sources

RETRACTED: Fusco et al. Formyl Peptide Receptor 1 Signaling in Acute Inflammation and Neural Differentiation Induced by Traumatic Brain Injury. Biology 2020, 9, 238 [PDF]

Biology
The journal retracts the article, “Formyl Peptide Receptor 1 Signaling in Acute Inflammation and Neural Differentiation Induced by Traumatic Brain Injury” [...]
Roberta Fusco, Enrico Gugliandolo, Rosalba Siracusa, Maria Scuto, Marika Cordaro, Ramona D’Amico, Maurizio Evangelista, Angelo Peli, Alessio Filippo Peritore, Daniela Impellizzeri, Rosalia Crupi, Salvatore Cuzzocrea, Rosanna Di Paola   +12 more
doaj   +2 more sources

Formyl Peptide Receptor Activation Elicits Endothelial Cell Contraction and Vascular Leakage

Frontiers in Immunology, 2016
The major pathophysiological characteristic of systemic inflammatory response syndrome (SIRS) and sepsis is the loss of control of vascular tone and endothelial barrier dysfunction. These changes are attributed to pro-inflammatory mediators.
Camilla Ferreira Wenceslau, Cameron Mccarthy, R Clinton Webb   +2 more
exaly   +3 more sources

Monoclonal Antibody 5F1 Modulates Formyl Peptide Receptor 1 Conformation for Transmembrane Signaling [PDF]

FASEB BioAdvances
Formyl peptide receptor 1 (FPR1) is a G protein‐coupled receptor (GPCR) that mediates chemotaxis and bactericidal activities in phagocytes. The monoclonal antibody 5F1 is generated against full‐length FPR1 and used widely for detection of FPR1 expression.
Yue Wang, Yezhou Liu, Yixin Chang, Richard D. Ye   +3 more
doaj   +2 more sources

Function of formyl peptide receptor 2 in adriamycin resistance of breast cancer [PDF]

Experimental Biology and Medicine
FPRL2 has been shown to be associated with a variety of tumours but has not been well studied in breast cancer. In this study, We combine molecular biology techniques with bioinformatics to analyze the role of FPRL2 in breast cancer and adriamycin ...
Landi Su, Jingjing Li, Li Qin, Yang Feng, Dingwen Xu   +4 more
doaj   +2 more sources

FITC Conjugation Markedly Enhances Hepatic Clearance of N-Formyl Peptides. [PDF]

PLoS ONE, 2016
In both septic and aseptic inflammation, N-formyl peptides may enter the circulation and induce a systemic inflammatory response syndrome similar to that observed during septic shock.
Cristina Ionica Øie, Igor Snapkov, Kjetil Elvevold, Baldur Sveinbjørnsson, Bård Smedsrød   +4 more
doaj   +1 more source

Formyl Peptide Receptors and Annexin A1: Complementary Mechanisms to Infliximab in Murine Experimental Colitis and Crohn’s Disease

Frontiers in Immunology, 2021
Non-responsiveness to anti-TNF-α therapies presents relevant rates in inflammatory bowel disease patients, presenting the need to find biomarkers involved in therapeutic efficacy.
Marina de Paula-Silva, Marina de Paula-Silva, Gustavo Henrique Oliveira da Rocha, Milena Fronza Broering, Maria Luíza Queiroz, Silvana Sandri, Rodrigo Azevedo Loiola, Sonia Maria Oliani, Andrea Vieira, Mauro Perretti, Sandra Helena Poliselli Farsky   +10 more
doaj   +1 more source

Structural basis for recognition of N-formyl peptides as pathogen-associated molecular patterns

Nature Communications, 2022
Detection of invading bacteria is key to immunity. Here, the authors report cryo-electron microscopy structures of agonist-bound formyl peptide receptor 1 (FPR1), that reveal structural basis for recognition of bacteria-derived formyl peptides.
Geng Chen, Xiankun Wang, Qiwen Liao, Yunjun Ge, Haizhan Jiao, Qiang Chen, Yezhou Liu, Wenping Lyu, Lizhe Zhu, Gydo C. P. van Zundert, Michael J. Robertson, Georgios Skiniotis, Yang Du, Hongli Hu, Richard D. Ye   +14 more
doaj   +1 more source

Structural basis of FPR2 in recognition of Aβ42 and neuroprotection by humanin

Nature Communications, 2022
The formyl peptide receptor 2 (FPR2) is involved in the pathogenesis of Alzheimer’s disease. Structures of FPR2 bound to Aβ42, humanin, or formyl peptides offer insight into Aβ42 neurotoxicity, humanin neuroprotection, and FPR ligand ...
Ya Zhu, Xiaowen Lin, Xin Zong, Shuo Han, Mu Wang, Yuxuan Su, Limin Ma, Xiaojing Chu, Cuiying Yi, Qiang Zhao, Beili Wu   +10 more
doaj   +1 more source