Results 41 to 50 of about 11,842 (181)

Targeting the Formyl Peptide Receptor type 1 to prevent the adhesion of ovarian cancer cells onto mesothelium and subsequent invasion

Journal of Experimental & Clinical Cancer Research, 2019
Background The biological behavior of epithelial ovarian cancer (EOC) is unique since EOC cells metastasize early to the peritoneum. Thereby, new anti-target agents designed to block trans-coelomic dissemination of EOC cells may be useful as anti ...
Michele Minopoli, Giovanni Botti, Vincenzo Gigantino, Concetta Ragone, Sabrina Sarno, Maria Letizia Motti, Giosuè Scognamiglio, Stefano Greggi, Cono Scaffa, Maria Serena Roca, Maria Patrizia Stoppelli, Gennaro Ciliberto, Nunzia Simona Losito, Maria Vincenza Carriero   +13 more
doaj   +1 more source

The Role of Formyl Peptide Receptor 1 in Uterine Contraction During Parturition

Frontiers in Pharmacology, 2021
Parturition involves the transformation of the quiescent myometrium into a highly excitable and contractile state, a process that is driven by changes in myometrial gene expression.
Chaolu Chen, Shuaiying Zhu, Long Bai, Meihua Sui, Meihua Sui, Danqing Chen   +5 more
doaj   +1 more source

Host Cell Protein Challenges in Antibody Processing: Insights Into Persistence and Mitigation Strategies

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Persistence of HCPs remains a major purification challenge in biopharmaceutical manufacturing with direct consequences for product quality, patient safety, and regulatory compliance. Over the last two decades, deeper insights into the mechanisms driving HCP persistence have clarified why certain proteins evade removal during purification ...
Younghoon Oh, Andrew Cooke, Harshal Soni, Susan Liu, Mamadou Bah, Brianna Bellis, Laura Smith, Michael Capaldi, Nicholas Levy, Erik Wilhelm, Kristopher Barnthouse   +10 more
wiley   +1 more source

Formyl peptide and its receptor system as a novel target for the prevention and treatment of neuroinflammation-related diseases

Brain Research Bulletin
Neuroinflammation is a hallmark pathological feature of various central nervous system (CNS) disorders. Persistent activation can trigger an imbalance between pro- and anti-inflammatory homeostasis, thereby exacerbating neuronal injury, demyelination ...
Zixuan Zhu, Xiaolan Yin, Rui Li, Wei Huang, Yaxin Yao, Hengming Lin, Siyu Yin, Bingbing Li, Qiong Ou, Shouhong Zhou   +9 more
doaj   +1 more source

Targeting neutrophil extracellular traps in metabolic and immune niche: Nanomaterials for diabetes tissue regeneration

BMEMat, EarlyView.
The effects of NETs on regeneration of various diabetic tissues, and strategies targeting NETs for diabetes tissue regeneration. In the diabetic environment, NETs undergo complex metabolic and immune reprogramming, leading to dynamic changes in antibacterial and proinflammatory functions, and affecting regeneration of multiple systemic tissues.
Xinyi Jiang, Muxin Yue, Kai Mao, Boon Chin Heng, Noor Azlin Yahya, Yunsong Liu, Zheng Li   +6 more
wiley   +1 more source

Biological Role of the N-Formyl Peptide Receptors

Immunopharmacology and Immunotoxicology, 2006
Ligation of N-formyl-methionyl-leucyl-phenylalanine (fMLP) to its specific cell surface receptors triggers different cascades of biochemical events, eventually leading to cellular activation. The formyl peptide receptors (FPRs) are members of the seven-transmembrane, G-protein coupled receptors superfamily, expressed at high levels on polymorphonuclear
PANARO MA, ACQUAFREDDA A, SISTO M, LISI S, MITOLO V., MAFFIONE, ANGELA BRUNA   +5 more
openaire   +3 more sources

Formyl peptide receptor 2 activation by mitochondrial formyl peptides stimulates the neutrophil proinflammatory response via the ERK pathway and exacerbates ischemia–reperfusion injury

Cellular & Molecular Biology Letters, 2023
Background Ischemia–reperfusion injury (IRI) is an inevitable process in renal transplantation that significantly increases the risk of delayed graft function, acute rejection, and even graft loss.
Yirui Cao, Juntao Chen, Feng Liu, Guisheng Qi, Yufeng Zhao, Shihao Xu, Jiyan Wang, Tongyu Zhu, Yi Zhang, Yichen Jia   +9 more
doaj   +1 more source

A Stable Isopterin Mimic of a Potent Bacterial Stimulant of T Cells

Chemistry – A European Journal, EarlyView.
A microbial metabolite covalently binds immunological protein MR1 to potently activate specific lymphocytes called MAIT cells, but it is too unstable for biological applications. Here, using synthesis, assays, protein crystallography, and computer modelling, we report a water‐stable analogue that activates reporter cells expressing the MAIT T cell ...
Jeffrey Y. W. Mak, Huy N. Hoang, Wael Awad, Xin Yi Lim, Damica D. Laurie, Ryan J. D. Rivero, James McCluskey, Alexandra J. Corbett, Jamie Rossjohn, David P. Fairlie   +9 more
wiley   +1 more source

Gut microbiota‐related modulation of immune mechanisms in post‐infarction remodelling and heart failure

ESC Heart Failure, Volume 12, Issue 2, Page 942-954, April 2025.
Abstract The immune system has long been recognized as a key driver in the progression of heart failure (HF). However, clinical trials targeting immune effectors have consistently failed to improve patient outcome across different HF aetiologies. The activation of the immune system in HF is complex, involving a broad network of pro‐inflammatory and ...
Johann Roessler, Friederike Zimmermann, Bettina Heidecker, Ulf Landmesser, Arash Haghikia   +4 more
wiley   +1 more source

FPR1 (formyl peptide receptor 1) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2012
Review on FPR1 (formyl peptide receptor 1), with data on DNA, on the protein encoded, and where the gene is implicated.
Huang, J, Wang, JM
openaire   +2 more sources