Results 21 to 30 of about 11,842 (181)

The Pyrazolone Originally Reported to Be a Formyl Peptide Receptor (FPR) 2/ALX–Selective Agonist Is Instead an FPR1 and FPR2/ALX Dual Agonist

Journal of Pharmacological Sciences, 2009
A pyrazolone compound acting as a formyl peptide receptor (FPR) 2/ALX–selective agonist has been reported, but its pharmacological activities on human FPRs (hFPRs) and mouse FPRs (mFprs) have not been well demonstrated.
Yoshitaka Sogawa, Akiko Shimizugawa, Takao Ohyama, Hiroaki Maeda, Kazuki Hirahara   +4 more
doaj   +1 more source

Formylated MHC Class Ib Binding Peptides Activate Both Human and Mouse Neutrophils Primarily through Formyl Peptide Receptor 1. [PDF]

PLoS ONE, 2016
Two different immune recognition systems have evolved in parallel to recognize peptides starting with an N-formylated methionine, and recognition similarities/differences between these two systems have been investigated.
Malene Winther, André Holdfeldt, Michael Gabl, Ji Ming Wang, Huamei Forsman, Claes Dahlgren   +5 more
doaj   +1 more source

Production of a bioengineered G-protein coupled receptor of human formyl peptide receptor 3. [PDF]

PLoS ONE, 2011
G-protein coupled receptors (GPCRs) participate in a wide range of vital regulations of our physiological actions. They are also of pharmaceutical importance and have become many therapeutic targets for a number of disorders and diseases.
Xiaoqiang Wang, Shuguang Zhang
doaj   +1 more source

Cytochalasin B triggers a novel pertussis toxin sensitive pathway in TNF-alpha primed neutrophils

BMC Cell Biology, 2004
Background Cytochalasin B does not directly activate the oxygen-radical-producing NADPH oxidase activity of neutrophils but transfers desensitized G-protein coupled receptors (GPCR) into an active signaling state by uncoupling GCPR from the cytoskeleton.
Mellqvist Ulf-Henrik, Fu Huamei, Pellmé Sara, Bylund Johan, Hellstrand Kristoffer, Karlsson Anna, Dahlgren Claes   +6 more
doaj   +1 more source

Effects of hypoxia on expression of formyl peptide receptor 1 in rat lung fibroblasts in vitro

Di-san junyi daxue xuebao, 2020
Objective To study the effect of hypoxia on the expression of formyl peptide receptor 1 (FPR1) in rat lung fibroblasts. Methods We tested the chemotactic activity of 10, 100, and 1 000 nmol/L FPR agonist (fMLF) for lung fibroblasts isolated from adult ...
LI Xiaoxu1, LI Xiaoxu1, LI Xiaoxu1, HUANG Jian1, HUANG Jian1, HUANG Jian1, JIAO Li1, JIAO Li1   +7 more
doaj   +1 more source

Mycobacteria attenuate nociceptive responses by formyl peptide receptor triggered opioid peptide release from neutrophils. [PDF]

PLoS Pathogens, 2009
In inflammation, pain is regulated by a balance of pro- and analgesic mediators. Analgesic mediators include opioid peptides which are secreted by neutrophils at the site of inflammation, leading to activation of opioid receptors on peripheral sensory ...
Heike L Rittner, Dagmar Hackel, Philipp Voigt, Shaaban Mousa, Andrea Stolz, Dominika Labuz, Michael Schäfer, Michael Schaefer, Christoph Stein, Alexander Brack   +9 more
doaj   +1 more source

Biased perspectives on formyl peptide receptors

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2019
The innate immune system is the first line of defense against pathogenic threats. For the early pathogen recognition and activation of cell protective mechanisms, germline-encoded pattern recognition receptors (PRRs) detect characteristic and evolutionary conserved pathogen-associated molecular patterns (PAMPs).
Carsten Alexander Raabe, Jieny Gröper, Ursula Rescher   +2 more
openaire   +2 more sources

Expression of acid cleavable Asp-Pro linked multimeric AFP peptide in E. coli

Journal of Genetic Engineering and Biotechnology, 2021
Background Difficult to express peptides are usually produced by co-expression with fusion partners. In this case, a significant mass part of the recombinant product falls on the subsequently removed fusion partner.
Murad Mollaev, Artur Zabolotskii, Neonila Gorokhovets, Elena Nikolskaya, Maria Sokol, Andrey Tsedilin, Mariia Mollaeva, Margarita Chirkina, Timofey Kuvaev, Anna Pshenichnikova, Nikita Yabbarov   +10 more
doaj   +1 more source

Structural Requirements for Molecular Recognition by fMLP Analogs Receptors: Comparative Conformational Analysis of (for-Met-Leu-Phe- OMe) and its Thioamide Analog (for-Met-Leuψ[CSNH]Phe-OMe)

Acta Chimica Slovenica, 2018
In order to determine the structural requirements of fMLP analogs receptors, this work presents the results of a comparative conformational analysis of the active chemotactic peptide (formyl-Met-Leu-Phe-OMe) and its inactive analog (formyl-Met-Leuψ [CSNH]
Chakib Ameziane Hassani, Mourad Houssat, Jamal Eddine Hazm, Ahmed Harrach   +3 more
doaj   +1 more source

Preservation of Post-Infarction Cardiac Structure and Function via Long-Term Oral Formyl Peptide Receptor Agonist Treatment

JACC: Basic to Translational Science, 2019
Summary: Dysregulated inflammation following myocardial infarction (MI) promotes left ventricular (LV) remodeling and loss of function. Targeting inflammation resolution by activating formyl peptide receptors (FPRs) may limit adverse remodeling and ...
Ricardo A. García, PhD, Bruce R. Ito, PhD, John A. Lupisella, MSc, Nancy A. Carson, BSc, Mei-Yin Hsu, MSc, Gayani Fernando, MSc, Madeleine Heroux, PhD, Michel Bouvier, PhD, Elizabeth Dierks, PhD, Ellen K. Kick, PhD, David A. Gordon, PhD, Jian Chen, PhD, Gabe Mintier, BSc, Marilyn Carrier, PhD, Stéphane St-Onge, MSc, Himanshu Shah, MSc, Jordan Towne, BSc, Marcela Sotelo Bucardo, BSc, Xiuying Ma, PhD, Carol S. Ryan, BSc, Nicholas R. Wurtz, PhD, Jacek Ostrowski, PhD, Francisco J. Villarreal, MD, PhD   +22 more
doaj   +1 more source