Revealing FPR1 as a potential pathogenic biomarker for aortic dissection based on Mendelian randomization, single-cell transcriptome and clinical data analysis [PDF]
Biology DirectBackground Aortic dissection is characterized by immune cell infiltration and vascular inflammation, yet its molecular mechanisms remain unclear. This study investigates the role of immune-related genes in AD pathogenesis. Methods We integrated Mendelian
Zhixin Li
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Agonist-specific FPR1 conformational change prevents receptor recycling and promotes targeted protein degradation [PDF]
Acta Pharmaceutica Sinica BRecycling of internalized cell surface receptors is critical for membrane transport and receptor-mediated signaling. Formyl peptide receptor 1 (FPR1) plays important roles in host defense and inflammatory tissue injury.
Junlin Wang +6 more
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Microenvironment involved in FPR1 expression by human glioblastomas [PDF]
Journal of Neuro-Oncology, 2015 Formyl peptide receptor 1 (FPR1) activity in U87 glioblastoma (GBM) cells contributes to tumor cell motility. The present study aimed to evaluate the FPR1 expression in human GBM, the possibility to elicit agonist induced FPR1 activation of GBM cells and inhibit this activation with chemotaxis inhibitory protein of Staphylococcus aureus (CHIPS ...
Jos A G Van Strijp +2 more
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OncoImmunology, 2021 Formyl peptide receptor 1 (FPR1) plays a key regulatory role in innate and adaptive immunity. Recently, we reported that the CC genotype of FPR1-E346A (rs867228, c. 1037 A > C) is an independent biomarker for patients with locally advanced rectal cancer (
Tao-Wei Ke +2 more
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Monoclonal Antibody 5F1 Modulates Formyl Peptide Receptor 1 Conformation for Transmembrane Signaling [PDF]
FASEB BioAdvancesFormyl peptide receptor 1 (FPR1) is a G protein‐coupled receptor (GPCR) that mediates chemotaxis and bactericidal activities in phagocytes. The monoclonal antibody 5F1 is generated against full‐length FPR1 and used widely for detection of FPR1 expression.
Yue Wang +3 more
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FPR1 mediates the tumorigenicity of human cervical cancer cells
Cancer Management and Research, 2018 Guangming Cao, Zhenyu Zhang Department of Obstetrics and Gynecology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China Purpose: The present study aimed to investigate the role of FPR1 and the downstream effectors such as NF-κB ...
Cao G, Zhang Z
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Formyl peptide receptor-1 (FPR1) represses intestinal oncogenesis
OncoImmunology, 2023 Formyl peptide receptor-1 (FPR1) is a pattern recognition receptor that is mostly expressed by myeloid cells. In patients with colorectal cancer (CRC), a loss-of-function polymorphism (rs867228) in the gene coding for FPR1 has been associated with ...
Julie Le Naour +17 more
doaj +6 more sources
No impact of cancer and plague-relevant FPR1 polymorphisms on COVID-19 [PDF]
OncoImmunology, 2020 Formyl peptide receptor 1 (FPR1) is a pattern-recognition receptor that detects bacterial as well as endogenous danger-associated molecular patterns to trigger innate immune responses by myeloid cells.
Adriana Petrazzuolo +9 more
doaj +4 more sources
Tumor suppressor function of formyl peptide receptor 1 in gastrointestinal cancers: a focus on the underlying signaling [PDF]
Frontiers in Cell and Developmental BiologyThe homeostasis of a tissue such the gastrointestinal (GI) tract is of fundamental importance for human health, given its constant exposure to a wide variety of external substances.
Maria Marotta +3 more
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FPR1 is the plague receptor on host immune cells [PDF]
Nature, 2019 The causative agent of plague, Yersinia pestis, uses a type III secretion system to selectively destroy immune cells in humans, thus enabling Y. pestis to reproduce in the bloodstream and be transmitted to new hosts through fleabites. The host factors that are responsible for the selective destruction of immune cells by plague bacteria are unknown ...
, Olaf Schneewind, Hwan Keun Kim
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