Results 21 to 30 of about 4,329 (161)
The ambiguous role of FPR1 in immunity and inflammation [PDF]
OncoImmunology, 2020 Formyl peptide receptors (FPRs) are pattern recognition receptors (PPRs) that are involved in multiple pathological processes.
Erika Vacchelli +2 more
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A major genetic accelerator of cancer diagnosis: rs867228 in FPR1 [PDF]
OncoImmunology, 2021 Over the last two decades, it has become clear that cancer is not a purely cell-autonomous disorder and that chronic inflammation as well as failure of immunosurveillance may have a decisive impact...
Sztupinszki, Zsofia +6 more
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Molecular Oncology, 2022 Formyl peptide receptors (FPR1, FPR2 and FPR3) are innate immune sensors of pathogen and commensal bacteria and have a role in colonic mucosa homeostasis.
Federica Liotti +9 more
doaj +1 more source
Intratracheal transplantation of mesenchymal stem cells attenuates hyperoxia-induced lung injury by down-regulating, but not direct inhibiting formyl peptide receptor 1 in the newborn mice. [PDF]
PLoS ONE, 2018 Formyl peptide receptor 1 (FPR1) has been shown to be a key regulator of inflammation. However, its role in bronchopulmonary dysplasia (BPD) has not been delineated yet.
Young Eun Kim +4 more
doaj +1 more source
Application of small molecule FPR1 antagonists in the treatment of cancers [PDF]
Scientific Reports, 2020 AbstractThe formylpeptide receptor-1 (FPR1) is a member of the chemotactic GPCR-7TM formyl peptide receptor family, whose principle function is in trafficking of various leukocytes into sites of bacterial infection and inflammation. More recently, FPR1 has been shown to be expressed in different types of cancer and in this context, plays a significant ...
Ahmet, Djevdet S. +12 more
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Biology, 2020 Traumatic brain injury (TBI) is a shocking disease frequently followed by behavioral disabilities, including risk of cerebral atrophy and dementia. N-formylpeptide receptor 1 (FPR1) is expressed in cells and neurons in the central nervous system.
Roberta Fusco +12 more
doaj +1 more source
FPR1 (formyl peptide receptor 1) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2012 Review on FPR1 (formyl peptide receptor 1), with data on DNA, on the protein encoded, and where the gene is implicated.
Huang, J, Wang, JM
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Formyl peptide derived lipopeptides disclose differences between the receptors in mouse and men and call the pepducin concept in question. [PDF]
PLoS ONE, 2017 A pepducin is a lipopeptide containing a peptide sequence that is identical to one of the intracellular domains of the G-protein coupled receptor (GPCR) assumed to be the target.
Malene Winther +7 more
doaj +1 more source
Cells, 2022 Annexin A1 (AnxA1) is a pleiotropic protein that exerts essential roles in breast cancer (BC) growth and aggressiveness. In our previous work, we described the autocrine signaling of AnxA1 through formyl peptide receptor 1 (FPR1) in the triple-negative ...
Lara Vecchi +9 more
doaj +1 more source
Exploring Biased Agonism at FPR1 as a Means to Encode Danger Sensing [PDF]
Cells, 2020 Ligand-based selectivity in signal transduction (biased signaling) is an emerging field of G protein-coupled receptor (GPCR) research and might allow the development of drugs with targeted activation profiles. Human formyl peptide receptor 1 (FPR1) is a GPCR that detects potentially hazardous states characterized by the appearance of N-formylated ...
Jieny Gröper +5 more
openaire +3 more sources