Results 11 to 20 of about 4,329 (161)

CH25H-mediated cholesterol metabolism drives chondrogenic differentiation in adipose-derived stem cells and enhances cartilage repair [PDF]

Communications Biology
Cartilage defects are difficult to heal because articular cartilage is both avascular and aneural. Directing adipose-derived mesenchymal stem cells (ADSCs) toward a chondrogenic fate in vitro is regarded as a promising therapeutic strategy.
Yang Wang, Wang Ye, Yi Chen, Yu Zhuang, Zixiong Qin, Dan Luo, Zhijing Ren, Zhen Yang   +7 more
doaj   +2 more sources

Regulation of the formyl peptide receptor 1 (FPR1) gene in primary human macrophages. [PDF]

PLoS ONE, 2012
The formyl peptide receptor 1 (FPR1) is mainly expressed by mammalian phagocytic leukocytes and plays a role in chemotaxis, killing of microorganisms through phagocytosis, and the generation of reactive oxygen species. A large number of ligands have been
Claudio Gemperle, Mattia Schmid, Magdalena Herova, Jacqueline Marti-Jaun, Sophia J A Wuest, Christa Loretz, Martin Hersberger   +6 more
doaj   +7 more sources

Parallel CRISPR screens reveal pathways controlling the cell surface levels of the attractant receptor FPR1 [PDF]

Communications Biology
Chemoattractants generate strong chemotactic and cytotoxic responses in immune cells by activating cognate receptors. Cell surface receptor levels control sensitivity, which is critical for achieving effective responses without excessive inflammation ...
Emel Akdoğan, Stefan M. Lundgren, Roarke A. Kamber, Michael C. Bassik, Sean R. Collins   +4 more
doaj   +2 more sources

FPR1: A critical gatekeeper of the heart and brain

Pharmacological Research
G protein-coupled receptors (GPCRs) are currently the most widely focused drug targets in the clinic, exerting their biological functions by binding to chemicals and activating a series of intracellular signaling pathways. Formyl-peptide receptor 1 (FPR1)
Ziyin Zhangsun, Yushu Dong, Jiayou Tang, Zhenxiao Jin, Wangrui Lei, Changyu Wang, Ying Cheng, Baoying Wang, Yang Yang, Huadong Zhao   +9 more
doaj   +3 more sources

Microbiota-dependent Formylated Peptide Receptor (Fpr1/2) Signaling Regulates Enteric Nervous System Development and Gastrointestinal Motility in MiceSummary [PDF]

Cellular and Molecular Gastroenterology and Hepatology
Background & Aims: Formylated peptide receptors 1 and 2 (Fpr1/2 or FPRs) are G-protein-coupled pattern recognition receptors that bind bacterial formylated peptides.
Bindu Chandrasekharan, Huixia Wu, Charlie Smoller, Jiyoung Kim, Alexandra A. Wolfarth, Richard Eboka, Darra Boyer, Amanda J. Metzger, Caroline R. Addis, Ken Liu, Shanthi Srinivasan, Andrew J. Macpherson, Rheinallt M. Jones, Andrew S. Neish   +13 more
doaj   +2 more sources

The role of formyl peptide receptor 1 (FPR1) in neuroblastoma tumorigenesis

BMC Cancer, 2016
Formyl peptide receptor 1 (FPR1) is a G protein-coupled receptor mainly expressed by the cells of myeloid origin, where it mediates the innate immune response to bacterial formylated peptides. High expression of FPR1 has been detected in various cancers but the function of FPR1 in tumorigenesis is poorly understood.Expression of FPR1 in neuroblastoma ...
Per Kogner, Baldur Sveinbjörnsson, John Inge Johnsen   +2 more
exaly   +4 more sources

The neutrophil extracellular trap-related gene FPR1 (formyl peptide receptor 1) as a potential prognostic and therapeutic target in osteosarcoma [PDF]

BMC Musculoskeletal Disorders
Background Neutrophil extracellular trap (NET) has been implicated in cancer progression and metastasis. Nevertheless, the role of the NET-related gene, formyl peptide receptor 1 (FPR1), in osteosarcoma (OS) remains largely unexplored.
Shihao Li, Qiong Yuan, Yuanyuan Zhang, Haiyang Zhang   +3 more
doaj   +2 more sources

Discovery of Yersinia LcrV as a novel biased agonist of formyl peptide receptor 1 to bi-directionally modulate intracellular kinases in triple-negative breast cancer [PDF]

Acta Pharmaceutica Sinica B
G protein-coupled receptors (GPCRs) are significant drug targets, but their potential in cancer therapy remains underexplored. Conventional GPCR agonists or antagonists have shown limited effectiveness in cancer treatment, necessitating new GPCR ...
Yunjun Ge, Huiwen Guan, Ting Li, Jie Wang, Liang Ying, Shuhui Guo, Jinjian Lu, Richard D. Ye, Guosheng Wu   +8 more
doaj   +2 more sources

Immunogenic cell death-related biomarkers in heart failure probed by transcriptome and single-cell sequencing [PDF]

Frontiers in Immunology
BackgroundHeart failure (HF) represents the terminal stage of various cardiovascular disorders, with immunogenic cell death (ICD) potentially influencing HF progression through modulation of immune cell activity.
Haoyue Wang, Haoyue Wang, Dongdong Wu, Dongdong Wu, Gangfei Han, Gangfei Han, Jingjing Yan, Zehui Wang, Xing He, Xing He, Yuxiang Chen, Yuxiang Chen, Yan Wang, Qinghua Han, Qinghua Han, Qinghua Han   +15 more
doaj   +2 more sources

Substantially Altered Local and Systemic Immunity in Ischemia-Free Versus Conventional Liver Transplantation. [PDF]

Adv Sci (Weinh)
This study investigates how ischemia‐free liver transplantation (IFLT) shapes both local and systemic immune responses compared with conventional liver transplantation (CLT). Our findings demonstrate that IFLT confers significant immunological protection by attenuating the STAT3‐HIF‐1α axis and enhancing the Heme‐HMOX1 pathway, two regulatory networks ...
Luo T, He S, Chen S, Ye D, Zhang S, Liu D, Zou D, Wang L, Chen H, Xu J, Liu H, Liu R, Tan X, Wang Y, Zeng J, Mo R, Li Y, Zhang Y, Ruan T, Wang T, Jia Z, Jia Y, Fang T, Lin Y, Liu X, Tang Y, Chen M, Zhao Q, Hu A, Ju W, Ma Y, Wang D, Zhu X, Andrea S, Zhai Y, Man K, Stefan TG, Gao Y, Bei J, He X, Guo Z.   +40 more
europepmc   +2 more sources