Formyl peptide receptor-1 (FPR1) represses intestinal oncogenesis [PDF]
OncoImmunology, 2023 Formyl peptide receptor-1 (FPR1) is a pattern recognition receptor that is mostly expressed by myeloid cells. In patients with colorectal cancer (CRC), a loss-of-function polymorphism (rs867228) in the gene coding for FPR1 has been associated with ...
Julie Le Naour +17 more
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The Role of Formyl Peptide Receptor 1 in Uterine Contraction During Parturition [PDF]
Frontiers in Pharmacology, 2021 Parturition involves the transformation of the quiescent myometrium into a highly excitable and contractile state, a process that is driven by changes in myometrial gene expression.
Chaolu Chen +5 more
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Honokiol suppresses formyl peptide-induced human neutrophil activation by blocking formyl peptide receptor 1 [PDF]
Scientific Reports, 2017 Formyl peptide receptor 1 (FPR1) mediates bacterial and mitochondrial N-formyl peptides-induced neutrophil activation. Therefore, FPR1 is an important therapeutic target for drugs to treat septic or sterile inflammatory diseases.
Fu-Chao Liu +7 more
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Inhibition of formyl peptide receptor-1-mediated cell death as a therapy for lethal cutaneous drug reactions in preclinical models [PDF]
Nature CommunicationsStevens-Johnson syndrome and toxic epidermal necrolysis are life-threatening mucocutaneous adverse drug reactions characterized by disseminated skin and mucosal detachment.
Haruna Kimura +8 more
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RETRACTED: Fusco et al. Formyl Peptide Receptor 1 Signaling in Acute Inflammation and Neural Differentiation Induced by Traumatic Brain Injury. Biology 2020, 9, 238 [PDF]
BiologyThe journal retracts the article, “Formyl Peptide Receptor 1 Signaling in Acute Inflammation and Neural Differentiation Induced by Traumatic Brain Injury” [...]
Roberta Fusco +12 more
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Knockout of Formyl Peptide Receptor-1 Attenuates Cigarette Smoke–Induced Airway Inflammation in Mice [PDF]
Frontiers in Pharmacology, 2021 Objective: The formyl peptide receptor-1 (FPR-1) has been reported to be implicated in the regulation of inflammatory disorders, while its role in cigarette smoke (CS)–induced airway inflammation has not been fully explained.
Lijuan Gao +9 more
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An independent predictor of poor prognosis in locally advanced rectal cancer: rs867228 in formyl peptide receptor 1 (FPR1) [PDF]
OncoImmunology, 2021 Formyl peptide receptor 1 (FPR1) plays a key regulatory role in innate and adaptive immunity. Recently, we reported that the CC genotype of FPR1-E346A (rs867228, c. 1037 A > C) is an independent biomarker for patients with locally advanced rectal cancer (
Shu-Fen Chiang +5 more
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Monoclonal Antibody 5F1 Modulates Formyl Peptide Receptor 1 Conformation for Transmembrane Signaling [PDF]
FASEB BioAdvancesFormyl peptide receptor 1 (FPR1) is a G protein‐coupled receptor (GPCR) that mediates chemotaxis and bactericidal activities in phagocytes. The monoclonal antibody 5F1 is generated against full‐length FPR1 and used widely for detection of FPR1 expression.
Yue Wang +3 more
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Tumor suppressor function of formyl peptide receptor 1 in gastrointestinal cancers: a focus on the underlying signaling [PDF]
Frontiers in Cell and Developmental BiologyThe homeostasis of a tissue such the gastrointestinal (GI) tract is of fundamental importance for human health, given its constant exposure to a wide variety of external substances.
Maria Marotta +3 more
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Increased expression of formyl peptide receptor-1 by basophils from patients with mastocytosis [PDF]
Journal of Allergy and Clinical Immunology: GlobalBackground: Symptoms in patients with systemic mastocytosis (SM) are associated with an increase in mast cell burden and release of mast cell–derived mediators.
Yuzhi Yin, MD, PhD +6 more
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