Antiflammin-2 Activates the Human Formyl-Peptide Receptor Like 1 [PDF]
The Scientific World Journal, 2006 The anti-inflammatory actions of the nonapeptide antiflammin-2, identified by homology with uteroglobin and annexin-A1 sequences, have been described in some detail, yet its mechanisms of action remain elusive.
Ahmad M. Kamal +6 more
doaj +5 more sources
Regulation of the formyl peptide receptor 1 (FPR1) gene in primary human macrophages. [PDF]
PLoS ONE, 2012 The formyl peptide receptor 1 (FPR1) is mainly expressed by mammalian phagocytic leukocytes and plays a role in chemotaxis, killing of microorganisms through phagocytosis, and the generation of reactive oxygen species. A large number of ligands have been
Claudio Gemperle +6 more
doaj +7 more sources
Biology, 2020 Traumatic brain injury (TBI) is a shocking disease frequently followed by behavioral disabilities, including risk of cerebral atrophy and dementia. N-formylpeptide receptor 1 (FPR1) is expressed in cells and neurons in the central nervous system.
Roberta Fusco +12 more
doaj +2 more sources
Formyl peptide receptor 1 suppresses gastric cancer angiogenesis and growth by exploiting inflammation resolution pathways [PDF]
OncoImmunology, 2017 Chronic inflammation can result from inadequate engagement of resolution mechanisms, mainly accomplished by specialized pro-resolving mediators (SPMs) arising from the metabolic activity of lipoxygenases (ALOX5/15) on ω-6 or ω-3 essential polyunsaturated
Nella Prevete +6 more
doaj +2 more sources
The neutrophil extracellular trap-related gene FPR1 (formyl peptide receptor 1) as a potential prognostic and therapeutic target in osteosarcoma [PDF]
BMC Musculoskeletal DisordersBackground Neutrophil extracellular trap (NET) has been implicated in cancer progression and metastasis. Nevertheless, the role of the NET-related gene, formyl peptide receptor 1 (FPR1), in osteosarcoma (OS) remains largely unexplored.
Shihao Li +3 more
doaj +2 more sources
The Expression of Formyl Peptide Receptor 1 is Correlated with Tumor Invasion of Human Colorectal Cancer [PDF]
Scientific Reports, 2017 Formyl peptide receptors (FPRs) are G protein-coupled chemoattractant receptors expressed mainly in phagocytic leukocytes. High expression of FPRs has also been detected in several cancers but the functions of FPR1 in tumor invasion and metastasis is ...
Shu-Qin Li +11 more
doaj +2 more sources
Differential requirement of formyl peptide receptor 1 in macrophages and neutrophils in the host defense against Mycobacterium tuberculosis Infection [PDF]
Scientific ReportsFormyl peptide receptors (FPR), part of the G-protein coupled receptor superfamily, are pivotal in directing phagocyte migration towards chemotactic signals from bacteria and host tissues.
Tanvir Noor Nafiz +7 more
doaj +2 more sources
Interleukin-6 Signaling in Triple Negative Breast Cancer Cells Elicits the Annexin A1/Formyl Peptide Receptor 1 Axis and Affects the Tumor Microenvironment [PDF]
Cells, 2022 Tiago Goss Santos +2 more
exaly +2 more sources
Turn-Adopting Peptidomimetic as a Formyl Peptide Receptor-1 Antagonist. [PDF]
ACS Pharmacol Transl SciThe design, synthesis, and characterization of a new peptidomimetic acting as a formyl peptide receptor (FPR1) antagonist (N-19004) are herein reported. The molecule has been identified with docking studies of the highly potent FPR1 antagonist UPARANT on human receptor.
De Fenza M +12 more
europepmc +5 more sources
Frontiers in Immunology, 2021 Non-responsiveness to anti-TNF-α therapies presents relevant rates in inflammatory bowel disease patients, presenting the need to find biomarkers involved in therapeutic efficacy.
Marina de Paula-Silva +10 more
doaj +1 more source