Results 31 to 40 of about 11,686 (159)
Aurantiamide-related dipeptide derivatives are formyl peptide receptor 1 antagonists. [PDF]
Medchemcomm, 2019 Aurantiamide is a useful scaffold to develop promising FPR1 antagonists capable of inhibiting neutrophil chemotaxis.
Mastromarino M +5 more
europepmc +5 more sources
Interaction of mitochondrial formylated peptides with formyl peptide receptor 1 in the pathogenesis of acute lung injury [PDF]
The Lancet, 2016 Abstract Background Mortality in acute respiratory distress syndrome remains high with no effective pharmacological therapies. The syndrome is characterised by dysregulated neutrophilic inflammation and tissue damage, which leads to the release of various factors including mitochondrial formylated peptides to drive neutrophil migration to sites of ...
David Dorward +12 more
openaire +1 more source
Biomedicines, 2021 Formyl peptide receptor-like 1 inhibitor (FLIPr), an Fcγ receptor (FcγR) antagonist, can be used as a carrier to guide antigen-FLIPr fusion protein to FcγR then enhances antigen-specific immune responses.
Chiao-Chieh Wu +3 more
doaj +1 more source
Identification of Peptides That Antagonize Formyl Peptide Receptor-Like 1-Mediated Signaling [PDF]
The Journal of Immunology, 2004 Abstract Formyl peptide receptor-like 1 (FPRL1) is an important classical chemoattractant receptor that is expressed in phagocytic cells in the peripheral blood and brain. Recently, various novel agonists have been identified from several origins, such as host-derived molecules.
Bae, YS +7 more
openaire +3 more sources
The American Journal of Pathology, 2015 Neutrophil migration to sites of inflammation and the subsequent execution of multiple functions are designed to contain and kill invading pathogens. These highly regulated and orchestrated processes are controlled by interactions between numerous receptors and their cognate ligands.
Dorward, David A. +5 more
openaire +2 more sources
Journal of Pharmacological Sciences, 2011 Formyl peptide receptor 1 (FPR1) and FPR2/ALX are known to control neutrophil chemotaxis in response to various ligands. In this study, we investigated the inhibitory mechanism of compound 43 (Cpd43), an FPR1 and FPR2/ALX dual agonist, on human ...
Yoshitaka Sogawa +3 more
doaj +1 more source
A Chemically Defined TLR3 Agonist with Anticancer Activity
OncoImmunology, 2023 Toll-like receptor 3 (TLR3) agonists such as polyinosinic:polycytidylic acid (poly(I:C)) have immunostimulatory effects that can be taken advantage of to induce anticancer immune responses in preclinical models. In addition, poly(I:C) has been introduced
Julie Le Naour +15 more
doaj +1 more source
House dust mite allergen activates human eosinophilsviaformyl peptide receptor and formyl peptide receptor‐like 1 [PDF]
European Journal of Immunology, 2007 AbstractThe objective was to evaluate which receptors house dust mite (HDM) and birch pollen extracts engage to activate human eosinophils. Chemotaxis and degranulation were studied in eosinophils pretreated with pertussis toxin and other antagonists of G protein‐coupled receptors,e.g.the formyl peptide receptor (FPR), CC chemokine receptor 3 (CCR3 ...
Svensson, Lena +7 more
openaire +4 more sources
Molecules, 2021 Little is known about the immunomodulatory activity of essential oils isolated from Juniperus species. Thus, we isolated essential oils from the cones and leaves of eight juniper species found in Montana and in Kazakhstan, including J.
Gulmira Özek +8 more
doaj +1 more source
Frontiers in Immunology, 2019 Despite recent advances in our understanding of the mechanisms underlying systemic inflammatory response syndrome (SIRS) and sepsis, the current therapeutic approach to these critically ill patients is centered around supportive care including fluid ...
Patricia Martinez-Quinones +6 more
doaj +1 more source