Results 21 to 30 of about 11,686 (159)
Structural basis for recognition of N-formyl peptides as pathogen-associated molecular patterns
Nature Communications, 2022 Detection of invading bacteria is key to immunity. Here, the authors report cryo-electron microscopy structures of agonist-bound formyl peptide receptor 1 (FPR1), that reveal structural basis for recognition of bacteria-derived formyl peptides.
Geng Chen +14 more
doaj +1 more source
The role of formyl peptide receptor 1 (FPR1) in neuroblastoma tumorigenesis. [PDF]
BMC Cancer, 2016 Formyl peptide receptor 1 (FPR1) is a G protein-coupled receptor mainly expressed by the cells of myeloid origin, where it mediates the innate immune response to bacterial formylated peptides. High expression of FPR1 has been detected in various cancers but the function of FPR1 in tumorigenesis is poorly understood.Expression of FPR1 in neuroblastoma ...
Snapkov I +5 more
europepmc +4 more sources
FPR1 (formyl peptide receptor 1) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2012 Review on FPR1 (formyl peptide receptor 1), with data on DNA, on the protein encoded, and where the gene is implicated.
Huang, J, Wang, JM
openaire +2 more sources
FITC Conjugation Markedly Enhances Hepatic Clearance of N-Formyl Peptides. [PDF]
PLoS ONE, 2016 In both septic and aseptic inflammation, N-formyl peptides may enter the circulation and induce a systemic inflammatory response syndrome similar to that observed during septic shock.
Cristina Ionica Øie +4 more
doaj +1 more source
Differential Activation of Formyl Peptide Receptor-Like 1 by Peptide Ligands [PDF]
The Journal of Immunology, 2003 Abstract Formyl peptide receptor-like 1 (FPRL1) plays a key role in the regulation of immune responses. The activation of FPRL1 induces a complicated pattern of cellular signaling, which results in the regulation of several immune responses, such as chemotactic migration and the production of reactive oxygen species (ROS).
Bae, YS +8 more
openaire +3 more sources
Life, 2022 Formyl peptide receptor type 2 (FPR2/ALX) belongs to the formyl peptide receptors (FPRs) family clustered on chromosome 19 and encodes a family of three Class A of G protein-coupled receptors (GPCRs).
Mariantonella Colucci +5 more
doaj +1 more source
The role of the host—Neutrophil biology
Periodontology 2000, EarlyView., 2023 Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple +4 more
wiley +1 more source
Cardiology Plus, 2021 Objectives: The aim of this study was to identify differentially expressed genes (DEGs) related to myocardial infarction (MI), which may serve as research and therapeutic targets.
Yu-Yao Ji +5 more
doaj +1 more source
CYCLOSPORIN H: A NOVEL ANTI-INFLAMMATORY THERAPY FOR INFLUENZA FLU PATIENTS [PDF]
Journal of the Egyptian Society of Parasitology, 2017 Relatively little is known about the inflammatory mediators and mechanisms that drive the progression of influenza flu infection to cytokine storm, lung dysfunction, organ failure, and ultimately death.
DONALD KREUTZER +2 more
doaj +1 more source
Molecular Neurodegeneration, 2012 Background Recent studies suggest that the chemotactic G-protein-coupled-receptor (GPCR) formyl-peptide-receptor-like-1 (FPRL1) and the receptor-for-advanced-glycation-end-products (RAGE) play an important role in the inflammatory response involved in ...
Slowik Alexander +7 more
doaj +1 more source