Formyl peptide receptors in the mucosal immune system [PDF]
Experimental and Molecular Medicine, 2020 Formyl peptide receptors: Receptors in the mucosal immune system Key receptors in defense against bacteria may also be attractive targets for diseases of the mucosa, the tissue that lines and protects areas such as the airways and gastrointestinal tract.
Yu Sun Jeong, Yoe-Sik Bae
doaj +5 more sources
The Role of Formyl Peptide Receptors in Neurological Diseases via Regulating Inflammation [PDF]
Frontiers in Cellular Neuroscience, 2021 Formyl peptide receptors (FPRs) are a group of G protein-coupled cell surface receptors that play important roles in host defense and inflammation. Owing to the ubiquitous expression of FPRs throughout different cell types and since they interact with ...
Jiahui Zhu +5 more
doaj +4 more sources
Promiscuous Receptors and Neuroinflammation: The Formyl Peptide Class
Life, 2022 Formyl peptide receptors, abbreviated as FPRs in humans, are G-protein coupled receptors (GPCRs) mainly found in mammalian leukocytes. However, they are also expressed in cell types crucial for homeostatic brain regulation, including microglia and blood ...
Edward S. Wickstead +2 more
doaj +7 more sources
The N-formyl peptide receptors: much more than chemoattractant receptors. Relevance in health and disease [PDF]
Frontiers in ImmunologyPattern Recognition Receptors (PRRs) are a superfamily of receptors that detect molecular structures typical for pathogens and damaged cells and play a crucial role in the proper function of the innate immune system.
Filomena Napolitano +2 more
doaj +4 more sources
The Formyl Peptide Receptors: Diversity of Ligands and Mechanism for Recognition [PDF]
Molecules, 2017 The formyl peptide receptors (FPRs) are G protein-coupled receptors that transduce chemotactic signals in phagocytes and mediate host-defense as well as inflammatory responses including cell adhesion, directed migration, granule release and superoxide ...
Hui-Qiong He, Richard D. Ye
doaj +4 more sources
Regulation of Inflammation and Oxidative Stress by Formyl Peptide Receptors in Cardiovascular Disease Progression [PDF]
Life, 2021 G protein-coupled receptors (GPCRs) are the most important regulators of cardiac function and are commonly targeted for medical therapeutics. Formyl-Peptide Receptors (FPRs) are members of the GPCR superfamily and play an emerging role in cardiovascular ...
Valentina Maria Caso +9 more
doaj +4 more sources
The G-Protein Coupled Formyl Peptide Receptors and Their Role in the Progression of Digestive Tract Cancer [PDF]
Technology in Cancer Research & Treatment, 2020 Chronic inflammation is a causative factor of many cancers, although it originally acts as a protective host response to the loss of tissue homeostasis. Many inflammatory conditions predispose susceptible cells, most of which are of epithelial origin, to
Cuimeng Tian MD +5 more
doaj +3 more sources
Formyl Peptide Receptors and Annexin A1: Complementary Mechanisms to Infliximab in Murine Experimental Colitis and Crohn’s Disease [PDF]
Frontiers in Immunology, 2021 Non-responsiveness to anti-TNF-α therapies presents relevant rates in inflammatory bowel disease patients, presenting the need to find biomarkers involved in therapeutic efficacy.
Marina de Paula-Silva +10 more
doaj +2 more sources
Formyl peptide receptors in bone research. [PDF]
Connect Tissue Res, 2023 The formyl peptide receptor (FPR) participates in the immune response, with roles in infection and inflammation. In this review article, we summarize the current literature on these roles before discussing the function of FPRs in the pathogenesis of musculoskeletal disorders including osteoarthritis (OA), degenerative disc disease (DDD), and rheumatoid
Lantieri MA +5 more
europepmc +3 more sources
Modified Signaling of Membrane Formyl Peptide Receptors in NADPH-Oxidase Regulation in Obesity-Resistant Mice [PDF]
Membranes, 2023 The signaling of membrane receptors is modified in obesity characterized by low-grade inflammation. The obesity-resistant state of organisms is poorly understood.
Irina Tikhonova +3 more
doaj +2 more sources