Results 41 to 50 of about 11,686 (159)

Effects of hypoxia on expression of formyl peptide receptor 1 in rat lung fibroblasts in vitro

Di-san junyi daxue xuebao, 2020
Objective To study the effect of hypoxia on the expression of formyl peptide receptor 1 (FPR1) in rat lung fibroblasts. Methods We tested the chemotactic activity of 10, 100, and 1 000 nmol/L FPR agonist (fMLF) for lung fibroblasts isolated from adult ...
LI Xiaoxu1, LI Xiaoxu1, LI Xiaoxu1, HUANG Jian1, HUANG Jian1, HUANG Jian1, JIAO Li1, JIAO Li1   +7 more
doaj   +1 more source

Formyl peptide receptor 1 up-regulation and formyl peptide receptor 2/3 down-regulation of blood immune cells along with defective lipoxin A4/resolvin D1 production in obstructive sleep apnea patients.

PLoS ONE, 2019
BACKGROUND:This study aims to investigate the role of FPR 1/2/3 expressions in patients with obstructive sleep apnea (OSA). METHOD:We made cross-sectional comparisons of FPR1/2/3 expressions of blood neutrophil, M1/M2a monocyte, and natural killer (NK ...
Yung-Che Chen, Mao-Chang Su, Chien-Hung Chin, I-Chun Lin, Po-Yuan Hsu, Chia-Wei Liou, Kuo-Tung Huang, Ting-Ya Wang, Yong-Yong Lin, Yi-Xin Zheng, Chang-Chun Hsiao, Meng-Chih Lin   +11 more
doaj   +1 more source

A Novel IDO1/NE Dual Inhibitor, IMM‐H018 Prevents the Primary and Secondary Sepsis and Ameliorates the Kidney Injury Through Inhibiting the Cytokine Storm and Microthrombosis, and Reversing Immunosuppression

Advanced Science, EarlyView.
IMM‐H018, a dual IDO1/NE inhibitor, demonstrates potent therapeutic efficacy in sepsis by simultaneously targeting excessive inflammation and immune dysfunction. It prevents both primary and secondary sepsis through anti‐inflammatory, immune‐restoring, and renoprotective mechanisms, reducing organ damage, improving immune homeostasis, preserving kidney
Yi Zhou, Xiaodi Zhao, Xiaochen Pan, Zhiling Ma, Huaqing Cui, Hui Wen, Peng Wang, Xiufeng Liao, Kejie Qin, Yuchen Wang, Li Sheng, Sen Zhang   +11 more
wiley   +1 more source

Lipoxin Receptors

The Scientific World Journal, 2007
Lipoxins (LXs) represent a class of arachidonic acid (AA) metabolites that carry potent immunoregulatory and anti-inflammatory properties, LXA4 and LXB4 being the main components of this series. LXs are generated by cooperation between 5-lipoxygenase (LO)
Mario Romano, Irene Recchia, Antonio Recchiuti   +2 more
doaj   +1 more source

Host Cell Protein Challenges in Antibody Processing: Insights Into Persistence and Mitigation Strategies

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Persistence of HCPs remains a major purification challenge in biopharmaceutical manufacturing with direct consequences for product quality, patient safety, and regulatory compliance. Over the last two decades, deeper insights into the mechanisms driving HCP persistence have clarified why certain proteins evade removal during purification ...
Younghoon Oh, Andrew Cooke, Harshal Soni, Susan Liu, Mamadou Bah, Brianna Bellis, Laura Smith, Michael Capaldi, Nicholas Levy, Erik Wilhelm, Kristopher Barnthouse   +10 more
wiley   +1 more source

Comparative analysis of formyl peptide receptor 1 and formyl peptide receptor 2 reveals shared and preserved signalling profiles

British Journal of Pharmacology
Background and PurposeThe pattern recognition receptors, formyl peptide receptors, FPR1 and FPR2, are G protein‐coupled receptors that recognize many different pathogen‐ and host‐derived ligands. While FPR1 conveys pro‐inflammatory signals, FPR2 is linked with pro‐resolving outcomes.
Denise Pajonczyk, Merle F. Sternschulte, Oliver Soehnlein, Marcel Bermudez, Carsten A. Raabe, Ursula Rescher   +5 more
openaire   +2 more sources

Chemotherapy-induced antitumor immunity requires formyl peptide receptor 1 [PDF]

Science, 2015
How dying tumor cells get noticed Besides killing tumor cells directly, some chemotherapies, such as anthracyclines, also activate the immune system to kill tumors. Vacchelli et al. discovered that in mice, anthracycline-induced antitumor immunity requires immune cells to ...
Vacchelli Erika, Ma Yuting, Baracco Elisa E, Sistigu Antonella, Enot David P, Pietrocola Federico, Yang Heng, Adjemian Sandy, Chaba Kariman, Semeraro Michaela, Signore Michele, Ninno Adele De, Lucarini Valeria, Peschiaroli Francesca, Businaro Luca, Gerardino Annamaria, Manic Gwenola, Ulas Thomas, Günther Patrick, Schultze Joachim L, Kepp Oliver, Stoll Gautier, Lefebvre Céline, Mulot Claire, Castoldi Francesca, Rusakiewicz Sylvie, Ladoire Sylvain, Apetoh Lionel, Pedro José Manuel Bravo San, Lucattelli Monica, Delarasse Cécile, Boige Valérie, Ducreux Michel, Delaloge Suzette, Borg Christophe, André Fabrice, Schiavoni Giovanna, Vitale Ilio, LaurentPuig Pierre, Mattei Fabrizio, Zitvogel Laurence, Kroemer Guido   +41 more
openaire   +6 more sources

Exploring Biased Agonism at FPR1 as a Means to Encode Danger Sensing

Cells, 2020
Ligand-based selectivity in signal transduction (biased signaling) is an emerging field of G protein-coupled receptor (GPCR) research and might allow the development of drugs with targeted activation profiles.
Jieny Gröper, Gabriele M. König, Evi Kostenis, Volker Gerke, Carsten A. Raabe, Ursula Rescher   +5 more
doaj   +1 more source

Targeting neutrophil extracellular traps in metabolic and immune niche: Nanomaterials for diabetes tissue regeneration

BMEMat, EarlyView.
The effects of NETs on regeneration of various diabetic tissues, and strategies targeting NETs for diabetes tissue regeneration. In the diabetic environment, NETs undergo complex metabolic and immune reprogramming, leading to dynamic changes in antibacterial and proinflammatory functions, and affecting regeneration of multiple systemic tissues.
Xinyi Jiang, Muxin Yue, Kai Mao, Boon Chin Heng, Noor Azlin Yahya, Yunsong Liu, Zheng Li   +6 more
wiley   +1 more source

Regulation of human formyl peptide receptor 1 synthesis: role of single nucleotide polymorphisms, transcription factors, and inflammatory mediators. [PDF]

PLoS ONE, 2011
The gene encoding the human formyl peptide receptor 1 (FPR1) is heterogeneous, containing numerous single nucleotide polymorphisms (SNPs). Here, we examine the effect of these SNPs on gene transcription and protein translation.
Heini M Miettinen
doaj   +1 more source