Results 31 to 40 of about 9,630 (179)

Differential activation of polymorphisms of the formyl peptide receptor by formyl peptides

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2007
We have investigated the role of two polymorphic sites (R190W and N192K) on the binding and activation of the formyl peptide receptor (FPR) by viral and formyl peptides. WEDWVGWI, a peptide with antiviral activity derived from the membrane proximal region of feline immunodeficiency virus, binds with high affinity to FPR.
openaire   +3 more sources

The N-formyl peptide receptors: contemporary roles in neuronal function and dysfunction

Neural Regeneration Research, 2020
N-formyl peptide receptors (FPRs) were first identified upon phagocytic leukocytes, but more than four decades of research has unearthed a plethora of non-myeloid roles for this receptor family.
Peter J.G. Cussell, Margarita Gomez Escalada, Nathaniel G.N. Milton, Andrew W.J. Paterson   +3 more
doaj   +1 more source

Mycobacteria attenuate nociceptive responses by formyl peptide receptor triggered opioid peptide release from neutrophils. [PDF]

PLoS Pathogens, 2009
In inflammation, pain is regulated by a balance of pro- and analgesic mediators. Analgesic mediators include opioid peptides which are secreted by neutrophils at the site of inflammation, leading to activation of opioid receptors on peripheral sensory ...
Heike L Rittner, Dagmar Hackel, Philipp Voigt, Shaaban Mousa, Andrea Stolz, Dominika Labuz, Michael Schäfer, Michael Schaefer, Christoph Stein, Alexander Brack   +9 more
doaj   +1 more source

A Novel IDO1/NE Dual Inhibitor, IMM‐H018 Prevents the Primary and Secondary Sepsis and Ameliorates the Kidney Injury Through Inhibiting the Cytokine Storm and Microthrombosis, and Reversing Immunosuppression

Advanced Science, EarlyView.
IMM‐H018, a dual IDO1/NE inhibitor, demonstrates potent therapeutic efficacy in sepsis by simultaneously targeting excessive inflammation and immune dysfunction. It prevents both primary and secondary sepsis through anti‐inflammatory, immune‐restoring, and renoprotective mechanisms, reducing organ damage, improving immune homeostasis, preserving kidney
Yi Zhou, Xiaodi Zhao, Xiaochen Pan, Zhiling Ma, Huaqing Cui, Hui Wen, Peng Wang, Xiufeng Liao, Kejie Qin, Yuchen Wang, Li Sheng, Sen Zhang   +11 more
wiley   +1 more source

Formyl peptide and its receptor system as a novel target for the prevention and treatment of neuroinflammation-related diseases

Brain Research Bulletin
Neuroinflammation is a hallmark pathological feature of various central nervous system (CNS) disorders. Persistent activation can trigger an imbalance between pro- and anti-inflammatory homeostasis, thereby exacerbating neuronal injury, demyelination ...
Zixuan Zhu, Xiaolan Yin, Rui Li, Wei Huang, Yaxin Yao, Hengming Lin, Siyu Yin, Bingbing Li, Qiong Ou, Shouhong Zhou   +9 more
doaj   +1 more source

Host Cell Protein Challenges in Antibody Processing: Insights Into Persistence and Mitigation Strategies

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Persistence of HCPs remains a major purification challenge in biopharmaceutical manufacturing with direct consequences for product quality, patient safety, and regulatory compliance. Over the last two decades, deeper insights into the mechanisms driving HCP persistence have clarified why certain proteins evade removal during purification ...
Younghoon Oh, Andrew Cooke, Harshal Soni, Susan Liu, Mamadou Bah, Brianna Bellis, Laura Smith, Michael Capaldi, Nicholas Levy, Erik Wilhelm, Kristopher Barnthouse   +10 more
wiley   +1 more source

Lipoxin-mediated signaling: ALX/FPR2 interaction and beyond

Pharmacological Research, 2023
In the aftermath of tissue injury or infection, an efficient resolution mechanism is crucial to allow tissue healing and preserve appropriate organ functioning. Pro-resolving bioactive lipids prevent uncontrolled inflammation and its consequences.
Sergio Sánchez-García, Rafael I. Jaén, María Fernández-Velasco, Carmen Delgado, Lisardo Boscá, Patricia Prieto   +5 more
doaj   +1 more source

Targeting neutrophil extracellular traps in metabolic and immune niche: Nanomaterials for diabetes tissue regeneration

BMEMat, EarlyView.
The effects of NETs on regeneration of various diabetic tissues, and strategies targeting NETs for diabetes tissue regeneration. In the diabetic environment, NETs undergo complex metabolic and immune reprogramming, leading to dynamic changes in antibacterial and proinflammatory functions, and affecting regeneration of multiple systemic tissues.
Xinyi Jiang, Muxin Yue, Kai Mao, Boon Chin Heng, Noor Azlin Yahya, Yunsong Liu, Zheng Li   +6 more
wiley   +1 more source

Biological Role of the N-Formyl Peptide Receptors

Immunopharmacology and Immunotoxicology, 2006
Ligation of N-formyl-methionyl-leucyl-phenylalanine (fMLP) to its specific cell surface receptors triggers different cascades of biochemical events, eventually leading to cellular activation. The formyl peptide receptors (FPRs) are members of the seven-transmembrane, G-protein coupled receptors superfamily, expressed at high levels on polymorphonuclear
PANARO MA, ACQUAFREDDA A, SISTO M, LISI S, MITOLO V., MAFFIONE, ANGELA BRUNA   +5 more
openaire   +3 more sources

Lipoxin Receptors

The Scientific World Journal, 2007
Lipoxins (LXs) represent a class of arachidonic acid (AA) metabolites that carry potent immunoregulatory and anti-inflammatory properties, LXA4 and LXB4 being the main components of this series. LXs are generated by cooperation between 5-lipoxygenase (LO)
Mario Romano, Irene Recchia, Antonio Recchiuti   +2 more
doaj   +1 more source