Results 11 to 20 of about 9,630 (179)

Formyl peptide receptors in the mucosal immune system [PDF]

Experimental and Molecular Medicine, 2020
Formyl peptide receptors: Receptors in the mucosal immune system Key receptors in defense against bacteria may also be attractive targets for diseases of the mucosa, the tissue that lines and protects areas such as the airways and gastrointestinal tract.
Yu Sun Jeong, Yoe-Sik Bae
doaj   +3 more sources

Modified Signaling of Membrane Formyl Peptide Receptors in NADPH-Oxidase Regulation in Obesity-Resistant Mice

Membranes, 2023
The signaling of membrane receptors is modified in obesity characterized by low-grade inflammation. The obesity-resistant state of organisms is poorly understood.
Irina Tikhonova, Alsu Dyukina, Elvira Shaykhutdinova, Valentina Safronova   +3 more
doaj   +1 more source

Structural basis of ligand binding modes at the human formyl peptide receptor 2

Nature Communications, 2020
Formyl peptide receptors (FPRs) are GPCRs that play important roles in transducing chemotactic signals in phagocytes and mediating host-defense and inflammatory responses. Here the authors present the 2.8 Å crystal structure of human FPR2 in complex with
Tong Chen, Muya Xiong, Xin Zong, Yunjun Ge, Hui Zhang, Mu Wang, Gye Won Han, Cuiying Yi, Limin Ma, Richard D. Ye, Yechun Xu, Qiang Zhao, Beili Wu   +12 more
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Expression and function of receptors for the formylated peptides in granulocytes of the patients with rheumatoid arthritis

Медицинская иммунология, 2022
Formyl peptide receptors (FPRs) are an important part of innate immunity involved in antimicrobial phagocyte functions such as chemotaxis, secretory degranulation, and respiratory burst.
A. Mohammad, Yu. V. Filina, R. V. Larionova, M. I. Arleevskaya, A. G. Gabdulhakova   +4 more
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The Role of Formyl Peptide Receptors in Neurological Diseases via Regulating Inflammation

Frontiers in Cellular Neuroscience, 2021
Formyl peptide receptors (FPRs) are a group of G protein-coupled cell surface receptors that play important roles in host defense and inflammation. Owing to the ubiquitous expression of FPRs throughout different cell types and since they interact with ...
Jiahui Zhu, Lingfei Li, Jiao Ding, Jinyu Huang, Anwen Shao, Bo Tang   +5 more
doaj   +1 more source

Formyl peptide receptor 2 and heart disease

Seminars in Immunology, 2022
Formyl peptide receptor type 2 (FPR2) regulates the initiation and resolution phases of the inflammatory response. In the setting of heart injury and disease, dysregulated inflammation can potentiate maladaptive healing and pathological remodeling of the heart leading to cardiac dysfunction and failure.
John A, Lupisella, Pravin S, Shirude, Nicholas R, Wurtz, Ricardo A, Garcia   +3 more
openaire   +2 more sources

The Two Formyl Peptide Receptors Differently Regulate GPR84-Mediated Neutrophil NADPH Oxidase Activity

Journal of Innate Immunity, 2021
Neutrophils express the two formyl peptide receptors (FPR1 and FPR2) and the medium-chain fatty acid receptor GPR84. The FPRs are known to define a hierarchy among neutrophil G protein-coupled receptors (GPCRs), that is, the activated FPRs can either ...
Jonas Mårtensson, Martina Sundqvist, Asmita Manandhar, Loukas Ieremias, Linjie Zhang, Trond Ulven, Xin Xie, Lena Björkman, Huamei Forsman   +8 more
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Involvement of formyl peptide receptors in receptor for advanced glycation end products (RAGE) - and amyloid beta 1-42-induced signal transduction in glial cells

Molecular Neurodegeneration, 2012
Background Recent studies suggest that the chemotactic G-protein-coupled-receptor (GPCR) formyl-peptide-receptor-like-1 (FPRL1) and the receptor-for-advanced-glycation-end-products (RAGE) play an important role in the inflammatory response involved in ...
Slowik Alexander, Merres Julika, Elfgen Anne, Jansen Sandra, Mohr Fabian, Wruck Christoph J, Pufe Thomas, Brandenburg Lars-Ove   +7 more
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Formylated MHC Class Ib Binding Peptides Activate Both Human and Mouse Neutrophils Primarily through Formyl Peptide Receptor 1. [PDF]

PLoS ONE, 2016
Two different immune recognition systems have evolved in parallel to recognize peptides starting with an N-formylated methionine, and recognition similarities/differences between these two systems have been investigated.
Malene Winther, André Holdfeldt, Michael Gabl, Ji Ming Wang, Huamei Forsman, Claes Dahlgren   +5 more
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Annexin A1 induces skeletal muscle cell migration acting through formyl peptide receptors. [PDF]

PLoS ONE, 2012
Annexin A1 (ANXA1, lipocortin-1) is a glucocorticoid-regulated 37-kDa protein, so called since its main property is to bind (i.e. to annex) to cellular membranes in a Ca(2+)-dependent manner.
Valentina Bizzarro, Raffaella Belvedere, Fabrizio Dal Piaz, Luca Parente, Antonello Petrella   +4 more
doaj   +1 more source