Results 171 to 180 of about 18,956 (211)

Formyl Peptide Receptor Expression in Birds

Immunopharmacology and Immunotoxicology, 2007
N-formyl-methionyl-leucyl-phenylalanine (fMLP) is a major chemotactic factor produced by Escherichia coli and other Gram-negative bacteria. The prototypal human fMLP receptor 1 (FPR1) was cloned in 1990 from a differentiated HL-60 myeloid leukemia cell cDNA library.
PANARO, Maria Antonietta, CIANCIULLI, ANTONIA, LISI, SABRINA, SISTO, MARGHERITA, Acquafredda, A, Mitolo, V.   +5 more
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Differential Activation of Formyl Peptide Receptor Signaling by Peptide Ligands

Molecular Pharmacology, 2003
Formyl peptide receptor (FPR) and formyl peptide receptor like 1 (FPRL1) play important roles in inflammation and immunity. Stimulation of FPR and FPRL1 initiates a cascade of signaling events, leading to activation of various phagocyte responses, including chemotaxis, superoxide generation, and exocytosis.
Bae, Yoe-Sik, Song, Ji Young, Kim, Youndong, He, Rong, Ye, Richard D., Kwak, Jong-Young, Suh, Pann-Ghill, Ryu, Sung Ho   +7 more
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Conformational Aspects of Human Formyl-peptide Receptor Agonists

Arzneimittelforschung, 2011
The conformation of several Met-Ile-Phe-Leu analogues was analyzed using circular dichroism and infra-red absorption. Their effect on human neutrophils was verified by receptor binding assays and measurements of lysozyme release. The results demonstrate that in amphipatic environments the compounds examined can be highly and weakly ordered in beta-turn
DALPIAZ, Alessandro, VERTUANI, Gianni, SCATTURIN, Angelo, VITALI F., VARANI, Katia, SPISANI, Susanna   +5 more
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The N-Formyl Peptide Receptor

1999
The chemotaxis of phagocytic leukocytes from the blood to tissues identifies the acute (neutrophil) and chronic (macrophages) inflammatory condition (1). This hallmark process is central to host defense against microorganisms, to mediation of the immune response, and to repair of injured tissues. When unregulated, however, it is also the key vehicle of
John S. Mills, Heini M. Miettinen, Michael J. Vlases, Algirdas J. Jesaitis   +3 more
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Formyl-Peptide Receptors in Infection, Inflammation, and Cancer

Trends in Immunology, 2018
Formyl-peptide receptors (FPRs) recognize bacterial and mitochondrial formylated peptides as well as endogenous non-formylated peptides and even lipids. FPRs are expressed on various host cell types but most strongly on neutrophils and macrophages. After the discovery of FPRs on leukocytes, it was assumed that these receptors predominantly govern a ...
Elisabeth, Weiß, Dorothee, Kretschmer
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Receptors for chemotactic formyl peptides as pharmacological targets

International Immunopharmacology, 2002
Leukocytes accumulate at sites of inflammation and immunological reaction in response to locally existing chemotactic mediators. N-formyl peptides, such as fMet-Leu-Phe (fMLF), are some of the first identified and most potent chemoattractants for phagocytic leukocytes.
Yingying, Le, Yiming, Yang, Youhong, Cui, Hiroshi, Yazawa, Wanghua, Gong, Cunping, Qiu, Ji Ming, Wang   +6 more
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Adaptive Evolution of Formyl Peptide Receptors in Mammals

Journal of Molecular Evolution, 2015
The formyl peptide receptors (FPRs) are a family of chemoattractant receptors with important roles in host defense and the regulation of inflammatory reactions. In humans, three FPR paralogs have been identified (FPR1, FPR2, and FPR3) and may have functionally diversified by gene duplication and adaptive evolution.
Yoshinori, Muto, Stéphane, Guindon, Toshiaki, Umemura, László, Kőhidai, Hiroshi, Ueda   +4 more
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N-Formylated humanin activates both formyl peptide receptor-like 1 and 2

Biochemical and Biophysical Research Communications, 2004
We have discovered that humanin (HN) acts as a ligand for formyl peptide receptor-like 1 (FPRL1) and 2 (FPRL2). This discovery was based on our finding that HN suppressed forskolin-induced cAMP production in Chinese hamster ovary (CHO) cells expressing human FPRL1 (CHO-hFPRL1) or human FPRL2 (CHO-hFPRL2). In addition, we found that N-formylated HN (fHN)
Masataka, Harada, Yugo, Habata, Masaki, Hosoya, Kazunori, Nishi, Ryo, Fujii, Makoto, Kobayashi, Shuji, Hinuma   +6 more
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Formyl Peptide Chemotactic Receptors of Leukocytes and Macrophages

1980
Publisher Summary Polymorphonuclear leukocytes, monocytes, and macrophages play a central role in host defence against invading microorganisms. However, the killing mechanisms employed by these motile cells are effective over short distances and require intimate cell-microorganism contact. A mechanism for ensuring efficient accumulation of phagocytic
J E, Niedel, P, Cuatrecasas
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Vomeronasal Formyl Peptide Receptors in mammals

2016
This thesis uncovers the genetic accidents that led to the acquisition of Formyl Peptide Receptor gene expression in the vomeronasal system of a rodent lineage that represents about 23% of the mammalian species. We also examined whether the cluster organization of vomeronasal genes is involved in the regulation of their expression with the presence of ...
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