Results 91 to 100 of about 142,967 (351)

HIC1 suppresses Tumor Progression and Enhances CD8+ T Cells Infiltration Through Promoting GSDMD‐induced Pyroptosis in Gastric Cancer

Advanced Science, EarlyView.
These findings elucidate the innovative role of HIC1 as a transcriptional activator in GC, driving the initiation of pyroptosis and enhancing CD8+ T cell infiltration, which has certain novelty and creative significance. Collectively, targeting HIC1 can present an appealing immunotherapeutic strategy to improve outcomes in GC patients.
Mengjie Kang, Wenqi Du, Lina Ding, Mengdi Wu, Dongsheng Pei   +4 more
wiley   +1 more source

Do dietary patterns in older men influence change in homocysteine through folate fortification? The Normative Aging Study [PDF]

Objective We aimed to describe the difference in B-vitamin intake and in plasma B-vitamin and homocysteine concentrations before and after folic acid fortification, in relation to dietary patterns. Design The Normative Aging Study (NAS) is a longitudinal
Groot, C.P.G.M., de, Knoops, K.T.B., Kromhout, D., Spiro, A., Staveren, W.A., van, Tucker, K.L.   +5 more
core   +2 more sources

Exploring food fortification potential of neglected legume and oil seed crops for improving food and nutrition security among smallholder farming communities: A systematic review

Journal of Agriculture and Food Research, 2021
A systematic review of literature on value-addition and food fortification of cereals using neglected legume and oil seed crops among smallholder farming communities was done.
Marongwe F. Desire, Masamha Blessing, Nyakudya Elijah, Mandumbu Ronald, Kamota Agather, Zengeza Tapiwa, Mapfeka R. Florence, Nyamadzawo George   +7 more
doaj  

Accurate Delivery of Mesenchymal Stem Cell Spheroids With Platelet‐Rich Fibrin Shield: Enhancing Survival and Repair Functions of Sp‐MSCs in Diabetic Wound Healing

Advanced Science, EarlyView.
Autologous plasma‐derived platelet‐rich fibrin (PRF) is prepared as a protective shield for mesenchymal stem cell spheroids (Sp‐MSCs). PRF forms a fibrin shield to protect Sp‐MSCs from the oxidative stress environment. The nutrients in PRF, particularly the α‐granules, can enhance the repair function of Sp‐MSCs.
Jinglve Zhang, Wenqing Xu, Yutian Xiao, Dingheng Su, Yusheng He, Huohong Yang, Yixin Xie, Xiaofang Wang, Ren‐He Xu, Shaorong Lei, Dingyu Wu   +10 more
wiley   +1 more source

Food fortification strategies to deliver nutrients for the management of iron deficiency anaemia

Current Research in Food Science, 2022
A rising trend in the global prevalence of anaemia is still prevailing. To combat micronutrient deficiencies, World Health Organisation/Food Agriculture Organisation (2006) guidelines recommended four chief strategies – supplementation, fortification ...
Naman Kaur, Aparna Agarwal, Manisha Sabharwal   +2 more
doaj  

Reducing the burden of iron deficiency anemia in Cote D’Ivoire through fortification

Journal of Health, Population and Nutrition, 2020
Background Iron deficiency anemia (IDA) is highly prevalent in the Cote d’Ivoire and has severe health and economic consequences. In this paper, we apply a health economic model to quantify the burden of IDA, and the contribution of nationwide mandatory ...
Alberto Prieto-Patron, Zsuzsa V. Hutton, Giovanni Fattore, Magalie Sabatier, Patrick Detzel   +4 more
doaj   +1 more source

Large-Scale Food Fortification and Biofortification in Low- and Middle-Income Countries: A Review of Programs, Trends, Challenges, and Evidence Gaps

Food and Nutrition Bulletin, 2018
Background: Food fortification and biofortification are well-established strategies to address micronutrient deficiencies in vulnerable populations. However, the effectiveness of fortification programs is not only determined by the biological efficacy of
S. Osendarp, H. Martínez, Greg S Garrett, L. Neufeld, L. De-Regil, M. Vossenaar, I. Darnton-Hill   +6 more
semanticscholar   +1 more source

Dual‐Locking the SARS‐CoV‐2 Spike Trimer: An Amphipathic Molecular “Bolt” Stabilizes Conserved Druggable Interfaces for Coronavirus Inhibition

Advanced Science, EarlyView.
A new amphipathic molecule, S416 is discovered, that locks the SARS‐CoV‐2 spike protein in its closed state, blocking viral entry. S416 acts as a molecular bolt, binding six sites: three between adjacent RBDs and three connecting NTDs to RBDs. This dual‐locking mechanism stiffens the spike structure and reduces its flexibility.
Shiliang Li, Fang Ye, Yucheng Zheng, Jie Wang, Haoran Peng, Lili Zhu, Lili Chen, Tao Yu, Huan Ge, Jiaqi He, Binghao Zhang, Jiayun Wu, Zhiyi Zhang, Liangliang Jiang, Geng Chen, Ping Zhao, Ke Lan, Zhenjiang Zhao, Xuhong Qian, Ke Xu, Yang Du, Honglin Li   +21 more
wiley   +1 more source

Thermal compaction as an alternative approach for full-RAP base layer construction

Scientific Reports
The use of Reclaimed Asphalt Pavement (RAP) in road base layers represents a solution to reduce the consumption of natural aggregates. However, the variability of RAP properties poses challenges to its application, particularly regarding mechanical ...
Lisley Madeira Coelho, Belayne Zanini Marchi, Pedro Henrique Poubel Mendonça da Silveira, Afonso Rangel Garcez de Azevedo, Sergio Neves Monteiro, Antônio Carlos Rodrigues Guimarães   +5 more
doaj   +1 more source

Influence of Curing Time on the Mechanical Behavior of Cold Recycled Bituminous Mix in Flexible Pavement Base Layer

Applied Sciences
This study examined the mechanical behavior characteristics of cold recycled emulsified asphalt bases with RAP 76% and emulsified asphalt 3%, in different cure time, i.e., 0, 7, 14 and 28 days and evaluated in terms of the resilient modulus (RM) and ...
Lisley Madeira Coelho, Rafael Pereira Kox, Antônio Carlos Rodrigues Guimarães, Rafael Travincas, Sergio Neves Monteiro   +4 more
doaj   +1 more source