Results 71 to 80 of about 1,336,459 (329)
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Forward models and passive psychotic symptoms [PDF]
Frontiers in Human Neuroscience, 2015 Pickering and Clark (2014) present two ways of viewing the role of forward models in human cognition: the auxiliary forward model (AFM) account and the integral forward model (IFM) account. The AFM account “assumes a dedicated prediction mechanism implemented by additional circuitry distinct from the core mechanisms of perception and action” (p.
openaire +4 more sources
Molecular Oncology, EarlyView.This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan +9 more
wiley +1 more source
Remote SensingStrapdown gravity systems are increasingly employed in airborne geophysical exploration and geodetic studies due to advantages such as ease of installation, wide dynamic range, and adaptability to various platforms, including airplanes, helicopters, and ...
Filippo Muccini +15 more
doaj +1 more source
Stochastic modeling error reduction using Bayesian approach coupled with an adaptive kriging based model [PDF]
, 2012 Magnetic material properties of an electromagnetic device can be recovered by solving an inverse problem where measurements are adequately interpreted by a mathematical forward model.
Dupré, Luc +1 more
core
Functional Methods in Stochastic Systems
, 2012 Field-theoretic construction of functional representations of solutions of stochastic differential equations and master equations is reviewed. A generic expression for the generating function of Green functions of stochastic systems is put forward ...
A.N. Vasiliev +9 more
core +1 more source
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
The Analysis of Forward-Looking Monetary Policy in a SVAR Framework [PDF]
This paper analyzes forward-looking monetary policy rules in structural VAR’s. First, an approach for modeling a monetary policy which aims at a strict medium term inflation or output growth target is developed.
Carlos Lenz +3 more
core
Forward Modeling of Space-borne Gravitational Wave Detectors
, 2003 Planning is underway for several space-borne gravitational wave observatories to be built in the next ten to twenty years. Realistic and efficient forward modeling will play a key role in the design and operation of these observatories.
A. Abramovici +27 more
core +1 more source
Molecular Oncology, EarlyView.This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert +13 more
wiley +1 more source