Results 81 to 90 of about 26,336 (149)

Perturbation of <i>Pseudomonas aeruginosa</i> peptidoglycan recycling by anti-folates and design of a dual-action inhibitor. [PDF]

mBio
Yaeger LN, Sychantha D, Luong P, Shekarriz S, Goncalves O, Dobrin A, Ranieri MR, Lamers RP, Harvey H, diCenzo GC, Surette M, Côté J-P, Magolan J, Burrows LL.   +13 more
europepmc   +1 more source

Metabolic traits and thresholds to inform marine ecological conservation and restoration

Journal of Applied Ecology, Volume 62, Issue 6, Page 1350-1363, June 2025.
Integrating organismal responses to environmental stressors into monitoring protocols can provide early warning indicators of ecosystem health. This approach strengthens conservation and restoration initiatives, supporting policy decisions in the face of increasing coastal development and climate change.
Mar Bosch‐Belmar, Francesco Paolo Mancuso, Mario Francesco Tantillo, Martina Russi, Viviana Piermattei, Daniele Piazzolla, Alice Madonia, Marco Marcelli, Gianluca Sarà   +8 more
wiley   +1 more source

Synergistic and antagonistic activities of IRF8 and FOS enhancer pairs during an immune-cell fate switch. [PDF]

EMBO J
Klonizakis A, Alcoverro-Bertran M, Massó P, Thomas J, de Andrés-Aguayo L, Wei X, Varamogianni-Mamatsi V, Nikolaou C, Graf T.   +8 more
europepmc   +1 more source

Different parts of the mussel Gigantidas haimaensis holobiont responded differently to deep‐sea sampling stress

Integrative Zoology, EarlyView.
Symbiotic gill and nonsymbiotic mantle of mussel Gigantidas haimaensis responded differently to deep‐sea sampling stress caused by acute environmental changes. Sharply increased transcription factors potentially play key roles in initiating the response of sampled deep‐sea macrobenthos to the sampling stress.
Guoyong YAN, Tong WEI, Yi LAN, Ting XU, Peiyuan QIAN   +4 more
wiley   +1 more source

Subepicardial adipose genes contribute to the deterioration of heart failure preserved ejection fraction. [PDF]

Front Cardiovasc Med
Zhang R, Wang M, Lang Y, Zhang J, Wang Y, Zheng H, Zheng Y, Zhou B.   +7 more
europepmc   +1 more source

Tissue‐specific methylomic responses to a lifestyle intervention in older adults associate with metabolic and physiological health improvements

Aging Cell, Volume 24, Issue 4, April 2025.
Diet and physical activity influence immunometabolic health across the lifespan, and DNA methylation may mediate a part of these effects. The Growing Old Together (GOTO) study, a 13‐week lifestyle intervention in older adults, revealed epigenetic changes in muscle, adipose, and blood at hundreds of CpGs, linking these to differential gene expression ...
Lucy Sinke, Marian Beekman, Yotam Raz, Thies Gehrmann, Ioannis Moustakas, Alexis Boulinguiez, Nico Lakenberg, Eka Suchiman, Fatih A. Bogaards, Daniele Bizzarri, Erik B. van den Akker, Melanie Waldenberger, Gillian Butler‐Browne, Capucine Trollet, C. P. G. M. de Groot, Bastiaan T. Heijmans, P. Eline Slagboom   +16 more
wiley   +1 more source

Dual-specificity tyrosine-regulated kinase 4 modulates the STAT3-FOS signaling axis to inhibit hepatitis B virus replication <i>via</i> autophagy. [PDF]

Int J Biol Sci
Xu J, Zeng X, Huang J, Ma S, Li K, Yang S, Naz W, Yousaf T, Yuan S, Liu Y, Zhang J, Liu C, Liu C, Zhai Z, Guo M, Sun G.   +15 more
europepmc   +1 more source

A Xanthine Derivative With Novel Heat Shock Protein 90‐Alpha Inhibitory and Senolytic Properties

Aging Cell, EarlyView.
This study aimed to find safe senolytic drugs that selectively eliminate senescent cells. Focusing on HSP90 inhibitors, we employed a virtual screening to identify novel, safer compounds (A). K5, a xanthinic candidate, effectively eliminated senescent cells in various cellular models (B), extended lifespan in flies, and reduced aging signs in mice (C).
Sandra Atlante, Luca Cis, Davide Pirolli, Michela Gottardi Zamperla, Veronica Barbi, Antonello Mai, Clemens Zwergel, Serena Marcozzi, Maria Elisa Giuliani, Giorgia Bigossi, Giovanni Lai, Fiorenza Orlando, Robertina Giacconi, Fabrizia Lattanzio, Giulia Matacchione, Chiara Giordani, Massimo Bracci, Fabiola Olivieri, Federico Boschi, Paola Tabarelli De Fatis, Giovanni Battista Ivaldi, Marco Malavolta, Antonella Farsetti, Maria Cristina De Rosa, Carlo Gaetano   +24 more
wiley   +1 more source

LARP3 inhibits the apoptosis of hepatocellular carcinoma via the ROS/PI3K/c-Fos axis. [PDF]

PLoS One
Zhu L, Meng Q, Qian W, Shao W, Lu Y, Jin S, Zhang A, Yan SG, Lu J.   +8 more
europepmc   +1 more source

Pyrroloquinoline Quinone Reprograms the Single‐Cell Landscape of Immune Aging in Hematopoietic Immune System

Aging Cell, EarlyView.
This study demonstrates that aging induces oxidative stress and inflammation in the hematopoietic immune system, resulting in immune homeostasis dysfunction, including alterations in B cells and hematopoietic stem cells, senescent cells (SnCs) accumulation, and senescence‐associated secretory phenotypes (SASPs) production. Notably, the study highlights
Xiuxing Liu, Chun Zhang, Jianjie Lv, Yidan Liu, Chenyang Gu, Yuehan Gao, Wen Ding, Hui Chen, Nanwei Xu, Hongbin Yin, Wenru Su, Zhuping Xu   +11 more
wiley   +1 more source