Results 111 to 120 of about 4,190 (169)

A Multiple‐Model‐Informed Drug‐Development Approach for Optimal Regimen Selection of an Oncolytic Virus in Combination With Pembrolizumab

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 572-582, March 2025.
ABSTRACT The antitumor efficacy of an intratumoral injection of a genetically engineered oncolytic vaccinia virus carrying human IL‐7 and murine IL‐12 genes (hIL‐7/mIL‐12‐VV) was demonstrated in CT26.WT‐bearing mice. In the CT26.WT‐bearing mouse model, the efficacy of the combination of hIL‐7/mIL‐12‐VV plus the anti‐programmed cell death protein (PD)‐1
Akihiro Yamada, Mary P. Choules, Frances A. Brightman, Shigeru Takeshita, Shinsuke Nakao, Nobuaki Amino, Takeshi Nakayama, Masato Takeuchi, Kanji Komatsu, Fernando Ortega, Hitesh Mistry, David Orrell, Christophe Chassagnole, Peter L. Bonate   +13 more
wiley   +1 more source

Widespread neuronal activity related to bimanual coordination in non-human primates: evidence from Fos-like activation during bimanual versus unimanual motor task. [PDF]

Neurosci Insights
Liu Y, Rouiller EM.
europepmc   +1 more source

Modeling of Disease Progression of Type 2 Diabetes Using Real‐World Data: Quantifying Competing Risks of Morbidity and Mortality

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 606-615, March 2025.
ABSTRACT Type 2 diabetes (T2D) is a progressive metabolic disorder that could be an underlying cause of long‐term complications that increase mortality. The assessment of the probability of such events could be essential for mortality risk management. This work aimed to establish a framework for risk predictions of macrovascular complications (MVC) and
Hanna Kunina, Stefan Franzén, Maria C. Kjellsson   +2 more
wiley   +1 more source

Course-Skill Atlas: A national longitudinal dataset of skills taught in U.S. higher education curricula. [PDF]

Sci Data
Javadian Sabet A, Bana SH, Yu R, Frank MR.   +3 more
europepmc   +1 more source

Electronegativity‐Driven Frontier Orbital Engineering in B‐Ti Diatomic Synergy Enables Selective Li2C2O4 Conversion in Li‐CO2 Batteries

Rare Metals, EarlyView.
ABSTRACT As a promising alternative to sluggish Li2CO3‐based Li‐CO2 electrochemistry, Li2C2O4 offers a favorable 2e− discharge pathway, yet its selective formation and reversible decomposition remain debated. Herein, we propose a nonmetal‐metal synergistic catalyst—B‐Ti coregulated layered transition metal boride Ti18B18O9/graphene (B‐Ti/TiBOG)—to ...
Qiong Peng, Tingting Luo, Man Zhu, Zixuan Tian, Zeyou Zhou, Yanli Chen, Yunpeng Qu, Xiaosi Qi, Zhimei Sun   +8 more
wiley   +1 more source

Impact of endogenous sonosensation on <i>in vivo</i> sonogenetics. [PDF]

iScience
Xian Q, Li D, Zhao X, Zhao D, Jiang Y, Jing J, Hou X, Huang X, Wong KF, Murugappan S, Qiu Z, Sun L.   +11 more
europepmc   +1 more source

DuckNet: an open‐source deep learning tool for waterfowl species identification in UAV imagery

Remote Sensing in Ecology and Conservation, EarlyView.
Using drones with thermal‐RGB sensors and a deep learning model (RetinaNet with ResNet‐50), we surveyed non‐breeding waterfowl across restored wetlands in the Mississippi Alluvial Valley. Our model, DuckNet, achieved high accuracy and offers an open‐source, customizable tool for automated waterfowl detection to support conservation monitoring ...
Zack Loken, Kevin M. Ringelman, Anne Mini, J. Dale James, Mike Mitchell   +4 more
wiley   +1 more source

From advanced imaging to molecular insights: the state of the art in omics for axial spondyloarthritis. [PDF]

Ther Adv Musculoskelet Dis
Arias-de la Rosa I, Martín-Salazar JE, Cuesta-López L, López-Medina C C, Escudero-Contreras A, Collantes-Estévez E, Barbarroja N, Puche-Larrubia MÁ.   +7 more
europepmc   +1 more source

Improving forest age estimation to understand subtropical forest regrowth dynamics using deep learning image segmentation of time‐series historical aerial photographs

Remote Sensing in Ecology and Conservation, EarlyView.
Accurately estimating forest age is key to understanding how forests recover and evaluating restoration success. We developed a two‐step deep learning approach using historical greyscale aerial photographs to map forest age at fine spatial scales. By combining a pre‐trained model with localized fine‐tuning, our U‐Net + ResNet50 architecture achieved ...
Ying Ki Law, Yi‐Fei Gu, Shuwen Liu, Guangqin Song, Aland H. Y. Chan, Cham Man Tse, Zhonghua Liu, Martha J. Ledger, Billy C. H. Hau, Sawaid Abbas, Jin Wu   +10 more
wiley   +1 more source

Mimicking opioid analgesia in cortical pain circuits. [PDF]

Nature
Oswell CS, Rogers SA, James JG, McCall NM, Hsu AI, Salimando GJ, Mahmood M, Wooldridge LM, Wachira M, Jo AY, Sandoval Ortega RA, Wojick JA, Beattie K, Farinas SA, Chehimi SN, Rodrigues A, Wu JWK, Ejoh LL, Kimmey BA, Lo E, Azouz G, Vasquez JJ, Banghart MR, Beier KT, Creasy KT, Crist RC, Ramakrishnan C, Reiner BC, Deisseroth K, Yttri EA, Corder G.   +30 more
europepmc   +1 more source