Results 131 to 140 of about 3,808 (149)

Different parts of the mussel Gigantidas haimaensis holobiont responded differently to deep‐sea sampling stress

Integrative Zoology, EarlyView.
Symbiotic gill and nonsymbiotic mantle of mussel Gigantidas haimaensis responded differently to deep‐sea sampling stress caused by acute environmental changes. Sharply increased transcription factors potentially play key roles in initiating the response of sampled deep‐sea macrobenthos to the sampling stress.
Guoyong YAN, Tong WEI, Yi LAN, Ting XU, Peiyuan QIAN   +4 more
wiley   +1 more source

The molecular impact of sonoporation: A transcriptomic analysis of gene regulation profile. [PDF]

Ultrason Sonochem
Duan X, Wan JMF, Yu ACH.
europepmc   +1 more source

Early positive tactile stimulation reverses the increase of anxiety and decrease of sociality induced by early chronic mechanical pain in mandarin voles

Integrative Zoology, EarlyView.
This study used a tail‐pinching model during development to simulate mechanical pain experienced by pups in high‐social mandarin voles (Microtus mandarinus). Subsequently, brush‐like positive tactile stimuli were applied to the backs of the mandarin voles.
Yahan SUN, Jiayu XIAO, Luoman LI, Haiwei NIU, Yiting ZHU, Lu LI, Wei QIAN, Yin LI, Lizi ZHANG, Yishan QU, Yuting BAI, Xiao HAN, Kaizhe HUANG, Zhixiong HE, Fadao TAI   +14 more
wiley   +1 more source

Deep brain stimulation of the Tbr1-deficient mouse model of autism spectrum disorder at the basolateral amygdala alters amygdalar connectivity, whole-brain synchronization, and social behaviors. [PDF]

PLoS Biol
Hsu TT, Huang TN, Wang CY, Hsueh YP.
europepmc   +1 more source

Tissue‐specific methylomic responses to a lifestyle intervention in older adults associate with metabolic and physiological health improvements

Aging Cell, Volume 24, Issue 4, April 2025.
Diet and physical activity influence immunometabolic health across the lifespan, and DNA methylation may mediate a part of these effects. The Growing Old Together (GOTO) study, a 13‐week lifestyle intervention in older adults, revealed epigenetic changes in muscle, adipose, and blood at hundreds of CpGs, linking these to differential gene expression ...
Lucy Sinke, Marian Beekman, Yotam Raz, Thies Gehrmann, Ioannis Moustakas, Alexis Boulinguiez, Nico Lakenberg, Eka Suchiman, Fatih A. Bogaards, Daniele Bizzarri, Erik B. van den Akker, Melanie Waldenberger, Gillian Butler‐Browne, Capucine Trollet, C. P. G. M. de Groot, Bastiaan T. Heijmans, P. Eline Slagboom   +16 more
wiley   +1 more source

Astrocytic inhibition of lateral septal neurons promotes diverse stress responses. [PDF]

Nat Commun
Seo K, Won S, Lee HY, Sin Y, Lee S, Park H, Kim YG, Yang SY, Kim DJ, Suk K, Koo JW, Baek M, Choi SY, Lee H.   +13 more
europepmc   +1 more source

A Xanthine Derivative With Novel Heat Shock Protein 90‐Alpha Inhibitory and Senolytic Properties

Aging Cell, EarlyView.
This study aimed to find safe senolytic drugs that selectively eliminate senescent cells. Focusing on HSP90 inhibitors, we employed a virtual screening to identify novel, safer compounds (A). K5, a xanthinic candidate, effectively eliminated senescent cells in various cellular models (B), extended lifespan in flies, and reduced aging signs in mice (C).
Sandra Atlante, Luca Cis, Davide Pirolli, Michela Gottardi Zamperla, Veronica Barbi, Antonello Mai, Clemens Zwergel, Serena Marcozzi, Maria Elisa Giuliani, Giorgia Bigossi, Giovanni Lai, Fiorenza Orlando, Robertina Giacconi, Fabrizia Lattanzio, Giulia Matacchione, Chiara Giordani, Massimo Bracci, Fabiola Olivieri, Federico Boschi, Paola Tabarelli De Fatis, Giovanni Battista Ivaldi, Marco Malavolta, Antonella Farsetti, Maria Cristina De Rosa, Carlo Gaetano   +24 more
wiley   +1 more source

Resveratrol reduces RVLM neuron activity via activating the AMPK/Sirt3 pathway in stress-induced hypertension. [PDF]

J Biol Chem
Wang LP, Liu TF, Dai TT, Deng X, Tong L, Zeng QC, He Q, Ren ZY, Zhang HL, Liu HS, Li YF, Li WZ, Zhang S, Du DS.   +13 more
europepmc   +1 more source

A Novel Cognitive Frailty Index for Geriatric Mice

Aging Cell, EarlyView.
Our study presents a groundbreaking longitudinal assessment of age‐related cognitive decline in a large cohort of aged mice. Through the development of the Cognitive Frailty Index (CoFI), we introduce a robust metric that correlates strongly with advancing age and mortality.
Serena Marcozzi, Giorgia Bigossi, Maria Elisa Giuliani, Giovanni Lai, Beatrice Bartozzi, Marta Balietti, Tiziana Casoli, Fiorenza Orlando, Andrea Amoroso, Robertina Giacconi, Maurizio Cardelli, Francesco Piacenza, Fabrizia Lattanzio, Fabiola Olivieri, Peter L. J. de Keizer, Fabrizio d’Adda di Fagagna, Marco Malavolta   +16 more
wiley   +1 more source

PACAP regulates neuroendocrine and behavioral stress responses via CRF-containing neurons of the rat hypothalamic paraventricular nucleus. [PDF]

Neuropsychopharmacology
Ebner K, Fontebasso V, Ferro F, Singewald N, Hannibal J.   +4 more
europepmc   +1 more source