Results 141 to 150 of about 4,222 (191)

The continuing significance of chiral agrochemicals

Pest Management Science, Volume 81, Issue 4, Page 1697-1716, April 2025.
In the time frame 2018–2023, around 43% of the 35 chiral agrochemicals introduced to the market (herbicides, fungicides, insecticides, acaricides, and nematicides) contain one or more stereogenic centers in the molecule, and almost 69% of them have been marketed as racemic mixtures of enantiomers or stereoisomers.
Peter Jeschke
wiley   +1 more source

Nasal respiration modulates pain perception via the olfactory Bulb-Anterior cingulate cortex circuit. [PDF]

iScience
Cheng R, Wang Y, Dou C, Gu S, Tang W, Chen C, Chen K, Cui S, Zhong W.   +8 more
europepmc   +1 more source

A Multiple‐Model‐Informed Drug‐Development Approach for Optimal Regimen Selection of an Oncolytic Virus in Combination With Pembrolizumab

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 572-582, March 2025.
ABSTRACT The antitumor efficacy of an intratumoral injection of a genetically engineered oncolytic vaccinia virus carrying human IL‐7 and murine IL‐12 genes (hIL‐7/mIL‐12‐VV) was demonstrated in CT26.WT‐bearing mice. In the CT26.WT‐bearing mouse model, the efficacy of the combination of hIL‐7/mIL‐12‐VV plus the anti‐programmed cell death protein (PD)‐1
Akihiro Yamada, Mary P. Choules, Frances A. Brightman, Shigeru Takeshita, Shinsuke Nakao, Nobuaki Amino, Takeshi Nakayama, Masato Takeuchi, Kanji Komatsu, Fernando Ortega, Hitesh Mistry, David Orrell, Christophe Chassagnole, Peter L. Bonate   +13 more
wiley   +1 more source

A molecularly defined brain circuit module for regulating panic-like defensive state. [PDF]

Nat Commun
Zhao M, Zhang L, Chen Z, Zhang S, Cheng X, Huang M, Li X, Gu H, Guan X, Geng D, Li Y, Tu Y, Xie Z, Zhang F, Ma H, Li X, Li D, Wu QF, Cao P.   +18 more
europepmc   +1 more source

Modeling of Disease Progression of Type 2 Diabetes Using Real‐World Data: Quantifying Competing Risks of Morbidity and Mortality

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 606-615, March 2025.
ABSTRACT Type 2 diabetes (T2D) is a progressive metabolic disorder that could be an underlying cause of long‐term complications that increase mortality. The assessment of the probability of such events could be essential for mortality risk management. This work aimed to establish a framework for risk predictions of macrovascular complications (MVC) and
Hanna Kunina, Stefan Franzén, Maria C. Kjellsson   +2 more
wiley   +1 more source

Molecular characterization of PANoptosis-related genes in chronic kidney disease. [PDF]

PLoS One
Zhang WT, Ge HW, Wei Y, Gao JL, Tian F, Zhou EC.   +5 more
europepmc   +1 more source

Subcutaneous Foslevodopa as Rescue Therapy for Abrupt Interruption of Oral Dopaminergic Treatment in Parkinson's Disease

Movement Disorders Clinical Practice, EarlyView.
Fabienne Ory‐Magne, Jean Luc Houeto, Margherita Fabbri   +2 more
wiley   +1 more source

Supersaturated Designs for Main Effects and Two‐Factor Interactions

Quality and Reliability Engineering International, EarlyView.
ABSTRACT Supersaturated designs (SSDs), which use fewer runs than factors, are employed in screening experiments to identify large main effects (MEs), even when the experimental setting may also involve factors that interact. This paper introduces new SSD design criteria that account for two‐factor interactions (2FIs) and compares them with designs ...
Byran J. Smucker, David J. Edwards, Maria L. Weese   +2 more
wiley   +1 more source

Increased matrix stiffness promotes fibrogenesis of hepatic stellate cells through AP-1-induced chromatin priming. [PDF]

Commun Biol
Zhao W, Yuan W, Dong T, Qi W, Feng Z, Li C, Sun Y.   +6 more
europepmc   +1 more source

DuckNet: an open‐source deep learning tool for waterfowl species identification in UAV imagery

Remote Sensing in Ecology and Conservation, EarlyView.
Using drones with thermal‐RGB sensors and a deep learning model (RetinaNet with ResNet‐50), we surveyed non‐breeding waterfowl across restored wetlands in the Mississippi Alluvial Valley. Our model, DuckNet, achieved high accuracy and offers an open‐source, customizable tool for automated waterfowl detection to support conservation monitoring ...
Zack Loken, Kevin M. Ringelman, Anne Mini, J. Dale James, Mike Mitchell   +4 more
wiley   +1 more source