Results 101 to 110 of about 1,403 (182)

Paternal Circadian Disruption Impairs Offspring Cognition via Sperm microRNAs

Advanced Science, Volume 13, Issue 37, 3 July 2026.
Paternal circadian disruption remodels the sperm small RNA payload, elevating miR‐92a‐3p/miR‐25‐3p levels and perturbing early embryonic gene regulatory programs. Microinjection experiments and single‐embryo transcriptomics reveal sex‐specific developmental vulnerabilities, ultimately impairing offspring hippocampal synaptic plasticity and cognition ...
Kexin Zou, Sisi Luo, Binliang Tang, Zhiqiang Liu, Yuchuan Zhou, Yicong Meng, Zhengmu Wu, Zheng Sun, Weihui Shi, Jianzhong Sheng, Chuanjin Yu, Zhenhua Li, Siyi Wei, Mo Zhang, Yujie Luo, Jing Yan, Xueyun Qin, Jiahang Mo, Chengliang Zhou, Jinsong Li, Hefeng Huang, Yifu Ding, Guolian Ding   +22 more
wiley   +1 more source

Nigra‐Subthalamic Dopaminergic Circuitry Modulates and Represents Distinct Pain Modality in Physiological and Pain States in Mice

Advanced Science, Volume 13, Issue 37, 3 July 2026.
Nigral dopaminergic (DA) neurons modulate and represent pain with a preference to a particular modality (mechanical) and laterality (contralateral), which are controlled by nigral GABAergic neurons. The pain modulation is mimicked by the nigro‐subthalamic projection and its downstream neurons, involving D2‐like receptors.
Ying Ji, Shuyi Li, Jiaqi Zhang, Xiang‐Ying Xu, Cui Yin, Mu Niu, Danyang Liu, Yanyu Jiang, Yong Niu, Su Liu, Bin Zhang, Guiyun Cui, Chunyi Zhou, Cheng Xiao   +13 more
wiley   +1 more source

An Activity‐Dependent NEPAS–PTX3 Axis Links Neurovascular and Myelin Deficits to Cognitive Impairment

Advanced Science, Volume 13, Issue 37, 3 July 2026.
An activity‐dependent pathway links prefrontal circuit hypoactivity to cognitive impairment. Reduced PVA–mPFC activity upregulates NEPAS, which suppresses PTX3 secretion, leading to impaired angiogenesis, myelin deficits, and memory decline. Rescue is achieved by NEPAS knockdown or chemogenetic circuit activation.
Boya Hu, Zifei Chen, Bingmei Sun, Jiale Gao, Jiale Xu, Xiaochun Guo, Fenfei Gao, Zhongsi Wang, Jie Wu, Xiaoyu Ji, Peipei Liu, Bing Huang   +11 more
wiley   +1 more source

Reduced SH3RF3 May Protect Against Alzheimer's Disease by Lowering Microglial Pro‐Inflammatory Responses via Modulation of JNK and NFkB Signaling

Glia, Volume 74, Issue 7, July 2026.
SNPs in SH3RF3 decrease the age of onset of Alzheimer's disease (AD). Reduced SH3RF3 blunts human microglial JNK and NFkB signaling and downstream inflammatory cytokine production, which may partially explain how SH3RF3 SNPs protect against AD. ABSTRACT Understanding how high‐risk individuals are protected from Alzheimer's disease (AD) may illuminate ...
Ronak Patel, Rong Cheng, Christopher L. Cardona, Ellen Angeles, Gunjandeep Singh, Sabrina Miller, Archana Ashok, Andrew F. Teich, Angel Piriz, Aleyda Maldonado, Ivonne Z. Jiménez‐Velázquez, Richard Mayeux, Joseph H. Lee, Andrew A. Sproul   +13 more
wiley   +1 more source

The Relationship Between Psychological Flexibility and Spiritual Well‐Being With Symptoms of Depression and Anxiety in Pregnant Women: A Cross‐Sectional Study

Health Science Reports, Volume 9, Issue 7, July 2026.
ABSTRACT Background and Aims Given the limited and contradictory evidence regarding the role of psychological flexibility and spirituality in depression and anxiety, this study aimed to examine the relationship between psychological flexibility and spiritual well‐being with symptoms of depression and anxiety among pregnant women.
Misha Sadeghian, Azita Ghanbarpour, Mohammad Hadi Yadollahpour, Zahra Geraili, Hajar Adib‐Rad, Mahbobeh Faramazi   +5 more
wiley   +1 more source

Tri‐Parametric Assessment of α‐Galactosidase A Activity, lysoGb3 and X‐Inactivation Aids Genotype‐Phenotype Categorization of Fabry Disease Female Patients

Journal of Inherited Metabolic Disease, Volume 49, Issue 4, July 2026.
ABSTRACT Fabry disease (FD, OMIM 301500) is an X‐linked lysosomal storage disorder caused by deficient activity of lysosomal alpha‐galactosidase A (AGAL, E.C. 3.2.1.22) due to pathogenic variants in the GLA gene (HGNC:4296, Xq22.1). Plasmatic deacylated globotriaosylceramide (lysoGb3) is elevated in FD patients as a reflection of lysosomal accumulation
Ladislav Kuchar, Lenka Dvorakova, Linda Berna, Martin Reboun, Petra Slavikova, Radovan Bakalar, Jana Ledvinova, Helena Poupetova, Petr Ruzicka, Asfaw Befekadu, Gabriela Dostalova, Stella Reichmannova, Ales Linhart, Jakub Sikora   +13 more
wiley   +1 more source

Dexmedetomidine Rapidly Relieves Stress‐Induced Hyperalgesia via Presynaptic α2‐Adrenergic Inhibition at Orbitofrontal–Insular Glutamatergic Synapses

MedComm, Volume 7, Issue 7, July 2026.
This study identified a maladaptive OFC–AIC glutamatergic circuit in stress‐induced hyperalgesia induction. This critical circuit provides an α2‐AR‐dependent braking target for dexmedetomidine to alleviate excessive glutamatergic transmission and hyperalgesia. ABSTRACT Dexmedetomidine (Dex), an α2‐adrenergic receptor (α2‐AR) agonist, is widely used for
Hui Rong, Yang‐Xun Zhang, Huijie Zhu, Yinyao Li, Yunfan Hou, Yun‐Yong Xie, Lu‐Yao Li, Bei‐Bei Zhang, Shu‐Tao Xie, Wei Zhang, Qi‐Peng Zhang, Xiao‐Yang Zhang, Jing‐Ning Zhu, Xiaoping Gu, Zhengliang Ma   +14 more
wiley   +1 more source

PMX‐CovEval: A Framework Including a Simulated Pharmacokinetic Database for Covariate Model Building Methods Benchmarking

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 7, July 2026.
ABSTRACT The development of new methods for covariate model building (CMB) in population pharmacokinetics (popPK) highlights the need for a standardized evaluation framework for method benchmarking. This data paper introduces PMX‐CovEval, a framework including a collection of datasets based on 127 distinct scenarios.
Mélanie Karlsen, Jérôme Azé, Sandra Bringay, Pascal Poncelet, David Fabre, David Marchionni, Elisa A. M. Calvier   +6 more
wiley   +1 more source

Molecular Interplay of PARN and Telomerase: Tail Modifiers and Disease Implications

WIREs RNA, Volume 17, Issue 4, July/August 2026.
Schematic representation of the molecular interplay between PARN, telomerase‐associated, and the involvement of p53 in regulating telomere maintenance and genome stability. The top panel shows how normal PARN levels are involved in regulating p53 levels and balanced telomerase activity through their regulatory interaction with TERC and TERRA, thus ...
Sujitha Felicitus, Shalon Suzanne Pinto, Sai Samanvitha Madagundapalli Ramakrishna, Dechamma Pandyanada Nanjappa, Gunimala Chakraborty, Anirban Chakraborty   +5 more
wiley   +1 more source

Occurrence and Provenance of KREEP Components in Glassy Agglutinates From Chang'e‐5 Lunar Regolith

Geochemistry, Geophysics, Geosystems, Volume 27, Issue 7, July 2026.
Abstract This study investigates the petrogenesis of glassy agglutinates in a polished section of the Chang'e‐5 lunar regolith sample CE5C0800YJYX018GP through integrated petrographic, mineralogical, and geochemical analyses of four representative particles (18GP‐01 to 18GP‐04).
Shuai Ma, Zhipeng Xia, Bingkui Miao
wiley   +1 more source