Molecular Mechanisms of Age‐Related Taste Dysfunction Deciphered by Spatiotemporal Transcriptomics
Multi‐omics profiling reveals that aging impairs stem/progenitor cell differentiation and taste bud regeneration in the posterior tongue. Age‐related macrophage polarization remodeling, marked by the accumulation of pro‐inflammatory M1 macrophages, contributes to a Thbs1‐enriched inhibitory niche that limits taste cell growth and differentiation ...
Wandong Zhao +15 more
wiley +1 more source
Transcriptomic Insights into Tumor Necrosis Factor α's Role in the Fibrosis-Related Processes of Equine Endometrial Fibroblasts. [PDF]
Sadowska A +5 more
europepmc +1 more source
Creb3l1 Overexpression Improves Flexor Tendon Repair in Aged Rats
Aging impairs flexor tendon repair, with aged tendons showing reduced Col1a1 and Sparc expression and compromised mechanical properties. The transcription factor Creb3l1 binds both gene promoters and drives their expression; its overexpression restores Col1a1 and Sparc levels and improves the gliding function, healing strength, and elastic modulus of ...
Qian Qian Yang +4 more
wiley +1 more source
Prevalence and antibiotic susceptibility patterns of bacteria causing surgical site infections in a tertiary care centers in Lebanon. [PDF]
Kawtharani I +5 more
europepmc +1 more source
Abstract Congenital aniridia is a rare genetic disorder primarily caused by pathogenic variants of the PAX6 gene. It leads to various panocular anomalies, including aniridia‐associated keratopathy (AAK). This review highlights recent insights into its pathogenesis, focusing on clinical staging, microstructural changes in the cornea and molecular ...
N. Szentmáry +27 more
wiley +1 more source
Dual Osteoprotective Actions of the Kefir Peptide KFP-1: Enhancement of Bone Formation and Suppression of Bone Resorption in Cells and Murine Models. [PDF]
Tung MC +7 more
europepmc +1 more source
ABSTRACT Online dissemination of conspiracy theories (CTs) during epidemics poses significant risks to public health. This paper addresses the problem of detecting CTs in social media posts with an emphasis on the resource‐constrained scenarios characterized by the scarcity of labelled datasets and expert annotations, and the lack of computational ...
Ipek Baris Schlicht +4 more
wiley +1 more source
Psychometric properties of the Feedback Orientation Scale in the clinical workplace of health professions students. [PDF]
Fuentes-Cimma J +5 more
europepmc +1 more source
Intercultural Competence Development Through Tourism: A Study of Czech Visitors to France
ABSTRACT This study examines international travel as a context for informal intercultural learning and the development of intercultural competence, aligning with the broader goals of training and development. Using the Cross‐Cultural Adaptability Inventory (CCAI), this research assesses changes in four dimensions—Emotional Resilience, Flexibility ...
Renata Cuhlova +2 more
wiley +1 more source
Here, we report isolation of acyl‐desferrioxamines from Actinoplanes teichomyceticus as a mixture of iron and aluminum complexes. The fraction containing these molecules exhibited antibacterial activity. We synthesized these molecules and found that they only exhibited antibacterial activity in the presence of aluminum.
Abiodun S. Oyedele +7 more
wiley +1 more source

