Results 131 to 140 of about 481 (199)

Biodesign and plant sciences: Evolving STEAM pedagogies in higher education. [PDF]

Quant Plant Biol
Danies G, Obregón C, Ojeda-Ramírez S, Burbano A.   +3 more
europepmc   +1 more source

Snapshots of Motion: A Novel Structural Intermediate Reveals Conserved Dynamics in Archaeal DNA Ligases

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT We present the first x‐ray crystallographic structural evidence of an archaeal DNA ligase showing the AMP covalent adduct together with further cofactor hydrolysis, capturing a transient intermediary in the first step of the ligation reaction, triggered by the pyrophosphate hydrolysis.
A. X. Quintana‐Armas, E. Flores‐Hernández, C. Cardona‐Félix, E. Rudiño‐Piñera   +3 more
wiley   +1 more source

A scheduling perspective on modular educational systems in Europe. [PDF]

Heliyon
Ruiz-Torrubiano R, Knopp S, Krystallidis A, Wolf LM.   +3 more
europepmc   +1 more source

The continuing significance of chiral agrochemicals

Pest Management Science, Volume 81, Issue 4, Page 1697-1716, April 2025.
In the time frame 2018–2023, around 43% of the 35 chiral agrochemicals introduced to the market (herbicides, fungicides, insecticides, acaricides, and nematicides) contain one or more stereogenic centers in the molecule, and almost 69% of them have been marketed as racemic mixtures of enantiomers or stereoisomers.
Peter Jeschke
wiley   +1 more source

Systematic metaproteomics mapping reveals functional and ecological landscapes of Ex vivo human gut microbiota responses to therapeutic drugs. [PDF]

Nat Commun
Li L, Simopoulos CMA, Mayne J, Ning Z, Zhang X, Hamada M, Butcher J, Serrana JM, Wang L, Cheng K, Qin H, Walker K, Zhang X, Stintzi A, Figeys D.   +14 more
europepmc   +1 more source

A Multiple‐Model‐Informed Drug‐Development Approach for Optimal Regimen Selection of an Oncolytic Virus in Combination With Pembrolizumab

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 572-582, March 2025.
ABSTRACT The antitumor efficacy of an intratumoral injection of a genetically engineered oncolytic vaccinia virus carrying human IL‐7 and murine IL‐12 genes (hIL‐7/mIL‐12‐VV) was demonstrated in CT26.WT‐bearing mice. In the CT26.WT‐bearing mouse model, the efficacy of the combination of hIL‐7/mIL‐12‐VV plus the anti‐programmed cell death protein (PD)‐1
Akihiro Yamada, Mary P. Choules, Frances A. Brightman, Shigeru Takeshita, Shinsuke Nakao, Nobuaki Amino, Takeshi Nakayama, Masato Takeuchi, Kanji Komatsu, Fernando Ortega, Hitesh Mistry, David Orrell, Christophe Chassagnole, Peter L. Bonate   +13 more
wiley   +1 more source

The effect of acupuncture on blood glucose control in patients with type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials. [PDF]

Front Endocrinol (Lausanne)
Si Y, Chen J, Chen L, Zheng Y, Qiu Y, Wang B, Liang Y, Zhang Y, Chen Y.   +8 more
europepmc   +1 more source

Harnessing Natural Compounds in Psoriasis: Targeting Cellular Pathways for Effective Therapy

Phytotherapy Research, EarlyView.
Natural compounds act on key cellular pathways in psoriasis by suppressing keratinocyte hyperproliferation, modulating Th17/IL‐17‐mediated immune responses, and reducing oxidative stress. These multi‐target effects highlight their potential as safer adjunctive therapies alongside conventional treatments.
Hye Jin Lee, Yu Jin So, Il‐Joo Jo, Ji Yong Jang, Tae Han Yook, Jun Ho Lee, Sung Wook Kim, Kangwook Lee, Soo Jung Park, Gabsik Yang   +9 more
wiley   +1 more source

Smoking and osteoimmunology: Understanding the interplay between bone metabolism and immune homeostasis. [PDF]

J Orthop Translat
Xie G, Huang C, Jiang S, Li H, Gao Y, Zhang T, Zhang Q, Pavel V, Rahmati M, Li Y.   +9 more
europepmc   +1 more source

Development of Coupled Electrochemical Systems for Metal Resource Recovery From Aqueous Metal‐Organic Complexes

Rare Metals, EarlyView.
ABSTRACT The past decade has witnessed a burgeoning demand of metals for global industrial development and infrastructure. Meanwhile, the depletion of mineral resources and the environmental damage caused by wastewater discharges pose significant threats to both economic and ecological sustainability. Fortunately, metal‐containing wastewaters also hold
Fei Zhang, Yu Cao, Yanjing Wang, Zhijuan Liu, Chao Xie, Yanyong Wang, Shuangyin Wang   +6 more
wiley   +1 more source