Results 11 to 20 of about 50 (50)
Chemoattractant-induced activation of c-fos gene expression in human monocytes. [PDF]
The Journal of experimental medicine, 1987 Human monocytes use the products of phosphoinositide hydrolysis (1,2-diacylglycerol and inositol 1,4,5-triphosphate) as second messengers to trigger rapid cellular activation during the occupancy of chemoattractant receptors. The effect of chemoattractants on modulation of gene expression in monocytes was examined in this study.
Y S, Ho, W M, Lee, R, Snyderman
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Functional dissection in vitro of the human c-fos promoter.
Journal of Biological Chemistry, 1991 Using internal and 5' deletions, the elements contributing to the in vitro activity of the human c-fos promoter have been identified. Wild type and mutant promoters were fused to the G-free cassette and tested, using HeLa nuclear and whole cell extracts, with the fos wild type promoter as the internal control.
R A, Hipskind, A, Nordheim
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Cell Structure and Function, 1990 Transcription of the c-fos gene is known to be induced transiently by many types of cellular stimuli in various cultured cell lines; however, several authors have reported that the c-fos gene is constitutively transcribed in lymphoid cells. We detected, in fact, abundant transcripts which hybridized with a v-fos DNA probe in nuclear run-off transcripts
K, Kikuchi, F, Makishima
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C-fos expression in vivo in human lymphocytes in response to stress
Progress in Neuro-Psychopharmacology and Biological Psychiatry, 1995 1. Blood samples from which lymphocytes were isolated were obtained from patients immediately prior to cardiac catheterization (stress period) and again four to five hours later (post-stress period). Blood was also taken from a normal non-stressed control subject. 2.
J E, Platt +4 more
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Expression of c-fos protooncogene in normal human peripheral blood granulocytes. [PDF]
The Journal of experimental medicine, 1987 We have investigated by Northern blot analysis the expression of c-fos protooncogene in human peripheral blood polymorphonuclear leukocytes (PMN). Freshly isolated PMN, unlike highly purified circulating lymphoid cells, showed high levels of c-fos transcripts.
F, Colotta +3 more
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Isolated human Fos promoter in plasmid DNA is overactive
AbstractChanges in intracellular concentrations of Na+and K+are shown to alterFosgene expression. Here, we obtained a genetic construct encodingTurboGFP-dest1gene under control of the humanFospromoter (−549; +155) and studied its expression in HEK293T.
Gorbunov Andrei +4 more
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In vitro transcriptional analysis of the human c-fos proto-oncogene.
Journal of Biological Chemistry, 1991 The transcription of the human c-fos promoter was characterized in vitro using HeLa nuclear and whole cell extracts. The c-fos gene and c-fos promoter fusions to the SV40 early region and the G-free cassette were active as templates, yielding faithfully initiated transcripts that were sensitive to alpha-amanitin.
R A, Hipskind, A, Nordheim
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High Levels of c-fos Proto-Oncogene Expression in Normal Human Adult Skin
Journal of Investigative Dermatology, 1990 The proto-oncogene c-fos is thought to play an important role in the modulation of cell growth and differentiation. In normal tissues that have been studied to date, c-fos expression has been found to be regulated in a tissue-specific manner. Actually, little is known about its expression in normal human adult skin (NHAS).
Basset-Séguin, Nicole +6 more
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Cold Spring Harbor Symposia on Quantitative Biology, 1986 I M, Verma +3 more
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Alteration of c-fos gene methylation in human gliomas
Molecular Carcinogenesis, 1996In an attempt to find a common DNA alteration occurring in human glioma, we examined DNA methylation in 34 gliomas of various pathological grades and compared them with those in normal cerebral subcortex DNA. The total methylated cytosine levels in the genome did not differ appreciably between the tumors and the normal tissues; however, the degree of ...
S, Uyeno +11 more
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