Results 91 to 100 of about 433,281 (311)

Functional Mapping of Neurodevelopmental Disease Pathways to Key Neurodevelopmental Processes Represented in the Developmental Neurotoxicity In Vitro Testing Battery

open access: yesAdvanced Science, EarlyView.
Human‐relevant methods are essential for modern chemical safety assessment. This study helps define the capabilities and boundaries of an in vitro testing battery for developmental neurotoxicity by exploring its biological applicability domain. By linking neurodevelopmental disease‐related pathways to key neurodevelopmental processes, the work enhances
Eliska Kuchovska   +14 more
wiley   +1 more source

Long-Term Memory Engram Cells Are Established by c-Fos/CREB Transcriptional Cycling

open access: yesCell Reports, 2018
Summary: Training-dependent increases in c-fos have been used to identify engram cells encoding long-term memories (LTMs). However, the interaction between transcription factors required for LTM, including CREB and c-Fos, and activating kinases such as ...
Tomoyuki Miyashita   +3 more
doaj   +1 more source

Nigra‐Subthalamic Dopaminergic Circuitry Modulates and Represents Distinct Pain Modality in Physiological and Pain States in Mice

open access: yesAdvanced Science, EarlyView.
Nigral dopaminergic (DA) neurons modulate and represent pain with a preference to a particular modality (mechanical) and laterality (contralateral), which are controlled by nigral GABAergic neurons. The pain modulation is mimicked by the nigro‐subthalamic projection and its downstream neurons, involving D2‐like receptors.
Ying Ji   +13 more
wiley   +1 more source

Aneurisma gigante de aorta ascendente y síndrome de vena cava superior

open access: yesRepertorio de Medicina y Cirugía, 2022
Introducción: el aneurisma gigante de aorta es una entidad poco frecuente y puede cursar asintomático por años o con manifestaciones inespecíficas.
Nicolas Felipe Peñazola Rey   +4 more
doaj  

Enhancement of capacity of farmer organizations for sustainable irrigation systems in Anuradhapura and Kurunegala districts [PDF]

open access: yes
Over the past decades public investment in major, medium and minor irrigation systems has not yielded the expected results. The solution to the growing water crisis lies in the institutional reform of existing social systems so as to manage the demand ...
Thiruchelvam, S.
core  

Identification of a Nerve Growth Factor-Regulated and Epidermal Growth Factor-Regulated Protein-Kinase That Phosphorylates the Protooncogene Product C-Fos [PDF]

open access: yes, 1993
Nerve growth factor (NGF) treatment of rat pheochromocytoma (PC12) cells induces the synthesis of the transcription factor c-Fos, which becomes highly phosphorylated relative to that produced as a result of depolarization of the cell.
Landreth, G. E.   +2 more
core  

A Photothermal Transducer Regulates Transmembrane Calcium Flow for Synergistic Osteoarthritis Therapy

open access: yesAdvanced Science, EarlyView.
Upon NIR irradiation at 808 nm, the activity of TRPV4 was inhibited by M2M@BPSC, which led to reduced calcium influx, mitochondrial protection, and, importantly, the transcriptional activation of the STAT6‐EGR2 pathway. The improved macrophage function indirectly readjusts the equilibrium between C‐ECM and F‐ECM to reconstruct a suitable ...
Chenqi Yu   +11 more
wiley   +1 more source

Production of FOS (Fructooligosaccharides) with fructosyltransferase enzymes and their effect on nutrient digestion in broilers [PDF]

open access: yesBIO Web of Conferences
This study aims to determine the influence of FOS on microbial populations, enzyme activity digestive tract and nutrient digestion in broilers. The research's periods were (1) FOS production; (2) the effect of FOS on intestinal bacterial, amylase and ...
Pantaya Dadik   +2 more
doaj   +1 more source

Study on Fructooligosaccharide (Fos) Production By Enzyme Pectinex Ultra Sp-l Immobilzed On Alginate [PDF]

open access: yes, 2017
Fructooligosaccharide (FOS) is a new alternative sweetener with its characteristics such as low energy and safety for people with diabetes.
Nguyen, B. T. (Binh)
core   +1 more source

Targeting m6A Reader YTHDF1 Enhances Antitumor Immunity and Potentiates Anti‐PD‐L1 Efficacy in Intrahepatic Cholangiocarcinoma

open access: yesAdvanced Science, EarlyView.
The m6A reader YTHDF1 drives intrahepatic cholangiocarcinoma (ICC) progression by remodeling the tumor immune microenvironment. YTHDF1 promotes MDSC recruitment via activation of m6A‐FOSL2‐CXCL6/CXCR2 axis, thereby suppressing CD8+ T cell infiltration and function.
Li Luo   +14 more
wiley   +1 more source

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