Therapeutic Potential of Fosmanogepix (APX001) for Intra-abdominal Candidiasis: from Lesion Penetration to Efficacy in a Mouse Model [PDF]
Antimicrobial Agents and Chemotherapy, 2021 Intra-abdominal candidiasis (IAC) is one of the most common yet underappreciated forms of invasive candidiasis. IAC is difficult to treat, and therapeutic failure and drug-resistant breakthrough infections are common in some institutions despite the use ...
Annie Lee +7 more
semanticscholar +5 more sources
Management of invasive candidiasis: A focus on rezafungin, ibrexafungerp, and fosmanogepix [PDF]
Pharmacotherapy: The Journal of Human Pharmacology and Drug TherapyManagement of invasive fungal infections is challenging with growing antifungal resistance. Broad antifungal use has resulted in greater intrinsic and acquired resistance among Candida spp.
Benjamin August, Pramodini Kale-Pradhan
semanticscholar +4 more sources
Efficacy of Delayed Therapy with Fosmanogepix (APX001) in a Murine Model of Candida auris Invasive Candidiasis [PDF]
Antimicrobial Agents and Chemotherapy, 2019 The emerging pathogenic yeast Candida auris is associated with antifungal resistance and high mortality. The novel antifungal agent manogepix (APX001A) inhibits glycosylphosphatidylinositol-anchored protein maturation and has demonstrated activity ...
Nathan P. Wiederhold +7 more
semanticscholar +6 more sources
Manogepix, the Active Moiety of the Investigational Agent Fosmanogepix, Demonstrates In Vitro Activity against Members of the Fusarium oxysporum and Fusarium solani Species Complexes [PDF]
Antimicrobial Agents and Chemotherapy, 2021 We evaluated the in vitro activity of manogepix against Fusarium oxysporum and Fusarium solani species complex (FOSC and FSSC, respectively) isolates per CLSI document M38 broth microdilution methods.
Hamid Badali +7 more
semanticscholar +5 more sources
Antimicrobial Agents and Chemotherapy, 2022 Aspergillus calidoustus is an emerging, azole-resistant, cryptic Aspergillus species in immunosuppressed patients that often features extrapulmonary involvement and carries high mortality. The case presented by J.
Ahnika Kline, Michail S. Lionakis
semanticscholar +5 more sources
1157. Clinical Safety, Efficacy, and Pharmacokinetics of Fosmanogepix, a Novel First-in-class Antifungal, in Patients with Renal Insufficiency: Subset Analysis from a Phase 2 Candidemia Trial [PDF]
Open Forum Infectious Diseases, 2020 Background Fosmanogepix (FMGX) is a first-in-class antifungal agent, with a unique MOA targeting the fungal enzyme Gwt1, and broad-spectrum activity against yeasts and molds, including fungi resistant to other antifungal agents.
Pierre Bulpa +11 more
semanticscholar +3 more sources
P-1351. Fosmanogepix Expanded Access Experience in Patients With Fusarium Infections [PDF]
Open Forum Infect DisBackground Fosmanogepix (FMGX; prodrug, active moiety manogepix [MGX]) is the first member of the “gepix” antifungal class. FMGX inhibits Gwt1, depleting GPI-anchor proteins important for fungal cell wall integrity; it shows consistent in vitro activity ...
Sanjeet Dadwal +9 more
europepmc +3 more sources
Identification of antifungal agents AR-12 and Fosmanogepix as anti- Trypanosoma cruzi drugs through an enhanced fluorogenic β-galactosidase phenotypic screening assay [PDF]
bioRxivPhenotypic screening remains essential for identifying and characterizing bioactive compounds or their combinations against human parasitic pathogens.
Mercedes Didier Garnham +4 more
semanticscholar +4 more sources
Antimicrobial Agents and Chemotherapy, 2020 Candida endophthalmitis is a serious sight-threatening complication of candidemia that may occur before or during antifungal therapy. Hematogenous Candida meningoencephalitis (HCME) is also a serious manifestation of disseminated candidiasis in premature
Rūta Petraitienė +7 more
semanticscholar +6 more sources
678. Galactomannan Is a Biomarker of APX001 (Fosmanogepix) Efficacy in Treating Experimental Invasive Pulmonary Aspergillosis [PDF]
Open Forum Infectious Diseases, 2019 Background Invasive pulmonary aspergillosis (IPA) is a serious fungal infection afflicting immunocompromised patients. Galactomannan (GM) detection in biological samples using the Platelia ELISA has been shown to predict therapy response by azoles, and ...
Teklegiorgis Gebremariam +6 more
semanticscholar +3 more sources