Results 31 to 40 of about 718 (128)
Internal Medicine Journal, Volume 53, Issue 8, Page 1489-1491, August 2023., 2023 Abstract Scedosporium and Lomentospora species are environmental moulds that are virulent in immunocompromised hosts and rarely cause bloodstream infection (BSI). Patients with Scedosporium and Lomentospora species BSI were identified by the state public laboratory service in Queensland, Australia, over a 20‐year period.
Adam G. Stewart +5 more
wiley +1 more source
A One Health approach to overcoming fungal disease and antifungal resistance
WIREs Mechanisms of Disease, Volume 15, Issue 4, July/August 2023., 2023 A One Health approach to fungal disease integrates environment, animal, and human health to uncover new antifungal therapies and overcome the increasing threat of antifungal resistance. Abstract The global burden of fungal disease poses a substantial threat to human, animal, and environmental health, endangering both human and livestock populations and
Michael Woods +2 more
wiley +1 more source
Antifungal chemotherapies and immunotherapies for the future
Parasite Immunology, Volume 45, Issue 2, February 2023., 2023 Abstract Human fungal pathogens cause a broad plethora of infections, spanning cutaneous dermatophytoses to invasive infections in immunocompromised hosts. As eukaryotic pathogens are capable of morphotype switching, they present unique challenges both for drug development and the immunological response.
Darius Armstrong‐James
wiley +1 more source
A Bibliometric Review on Candida auris of the First Fifteen Years of Research (2009‐2023)
BioMed Research International, Volume 2023, Issue 1, 2023., 2023 Introduction. Candida auris is a relatively novel pathogen first described in 2009 in Japan. It has increased its presence worldwide, becoming a public health concern due to its innate resistance to antifungals and outbreak potential. Methods.
Hiram Villanueva-Lozano +5 more
wiley +1 more source
Journal of Computational Chemistry, Volume 43, Issue 32, Page 2121-2130, December 15, 2022., 2022 The co‐crystal structure of an imidazopyridine ligand (1) complex with Candida albicans Bdf1 BD2, a novel anti‐fungal drug target, reveals that one (W1) among six structural water molecules has been displaced. Molecular dynamic simulations provided insight into the mechanistic role of the displacement process.
Yingsheng Zhou +8 more
wiley +1 more source
APMIS, Volume 130, Issue 9, Page 568-577, September 2022., 2022 Biofilms formed by Candida species present a significant clinical problem due to the ineffectiveness of many conventional antifungal agents, in particular the azole class. We urgently require new and clinically approved antifungal agents quickly for treatment of critically ill patients.
Hafsa Abduljalil +9 more
wiley +1 more source
Superbugs or multidrug resistant microbes: A new threat to the society
, 2023 Health Science Reports, Volume 6, Issue 8, August 2023.
Sakshi Painuli +3 more
wiley +1 more source
Fungal Cell Wall: Emerging Antifungals and Drug Resistance
Frontiers in Microbiology, 2019 The cell wall is an essential component in fungal homeostasis. The lack of a covering wall in human cells makes this component an attractive target for antifungal development. The host environment and antifungal stress can lead to cell wall modifications
Soraia L. Lima +2 more
doaj +1 more source
Hope on the horizon: Novel fungal treatments in development [PDF]
, 2020 The treatment of invasive fungal infections remains challenging due to limitations in currently available antifungal therapies including toxicity, interactions, restricted routes of administration, and drug resistance.
Rauseo, Adriana M +3 more
core +1 more source
Exploring the Depths of Cryptic Aspergillosis: Species Variability, Clinical Spectrum, Diagnostic Quandaries and Therapeutic Options [PDF]
Journal of Clinical and Diagnostic ResearchCryptic aspergillosis, characterised by infections caused by non classical Aspergillus species, presents unique challenges in clinical management due to species variability, diverse clinical manifestations, diagnostic complexities, and limited treatment ...
Almas Fathima Upaisal +1 more
doaj +1 more source