Results 41 to 50 of about 848 (155)
Heightened Efficacy of Anidulafungin When Used in Combination with Manogepix or 5-Flucytosine against Candida auris In Vitro. [PDF]
, 2023 Candida auris is an emerging, multidrug-resistant fungal pathogen that causes refractory colonization and life-threatening, invasive nosocomial infections. The high proportion of C.
Bicanic, T +6 more
core +2 more sources
S4.1a Fusariosis: MICs, mono versus combination therapy and fosmanogepix
Medical Mycology, 2022 Abstract S4.1 Treatment of rare mold infections in 2021: the role of new and old antifungals, September 22, 2022, 10:30 AM - 12:00 PM Fusarium is one of the most clinically prevalent rare molds causing superficial infections such as keratitis in immunocompetent hosts and severe disseminated infections
openaire +1 more source
Journal of Computational Chemistry, Volume 43, Issue 32, Page 2121-2130, December 15, 2022., 2022 The co‐crystal structure of an imidazopyridine ligand (1) complex with Candida albicans Bdf1 BD2, a novel anti‐fungal drug target, reveals that one (W1) among six structural water molecules has been displaced. Molecular dynamic simulations provided insight into the mechanistic role of the displacement process.
Yingsheng Zhou +8 more
wiley +1 more source
APMIS, Volume 130, Issue 9, Page 568-577, September 2022., 2022 Biofilms formed by Candida species present a significant clinical problem due to the ineffectiveness of many conventional antifungal agents, in particular the azole class. We urgently require new and clinically approved antifungal agents quickly for treatment of critically ill patients.
Hafsa Abduljalil +9 more
wiley +1 more source
678. Galactomannan Is a Biomarker of APX001 (Fosmanogepix) Efficacy in Treating Experimental Invasive Pulmonary Aspergillosis [PDF]
Open Forum Infectious Diseases, 2019 Abstract Background Invasive pulmonary aspergillosis (IPA) is a serious fungal infection afflicting immunocompromised patients. Galactomannan (GM) detection in biological samples using the Platelia ELISA has been shown to predict therapy response by azoles, and polyenes.
Gebremariam, Teklegiorgis +6 more
openaire +1 more source
Cellular Microbiology, Volume 2022, Issue 1, 2022., 2022 Although Candida species are widespread commensals of the microflora of healthy individuals, they are also among the most important human fungal pathogens that under certain conditions can cause diseases (candidiases) of varying severity ranging from mild superficial infections of the mucous membranes to life‐threatening systemic infections.
Dorota Satala +8 more
wiley +1 more source
Model‐Informed Drug Development for Anti‐Infectives: State of the Art and Future
Clinical Pharmacology &Therapeutics, Volume 109, Issue 4, Page 867-891, April 2021., 2021 Model‐informed drug development (MIDD) has a long and rich history in infectious diseases. This review describes foundational principles of translational anti‐infective pharmacology, including choice of appropriate measures of exposure and pharmacodynamic (PD) measures, patient subpopulations, and drug‐drug interactions.
Craig R. Rayner +14 more
wiley +1 more source
Superbugs or multidrug resistant microbes: A new threat to the society
, 2023 Health Science Reports, Volume 6, Issue 8, August 2023.
Sakshi Painuli +3 more
wiley +1 more source
Aspiring Antifungals: Review of Current Antifungal Pipeline Developments
Journal of Fungi, 2020 Invasive fungal infections are associated with significant morbidity and mortality, and their management is restricted to a variety of agents from five established classes of antifungal medication.
Thomas J. Gintjee +2 more
doaj +1 more source
Endemic mycoses - are we making progress in management? [PDF]
, 2023 PURPOSE OF REVIEW: The endemic fungi are a significant cause of morbidity and mortality in effected patients. The range of endemicity for these are expanding with infections observed outside of traditional locations.
Bahr, Nathan, Thompson, George
core +1 more source