Results 41 to 50 of about 718 (128)

Management of Invasive Pulmonary Aspergillosis in Intensive Care Units: Guidelines From the Fungal Infection Network of Switzerland (FUNGINOS)

Mycoses, Volume 68, Issue 11, November 2025.
ABSTRACT Invasive pulmonary aspergillosis (IPA) is increasingly recognised in intensive care units (ICU) affecting not only patients with classical immunosuppressive conditions but also other severely ill patients, including those with respiratory viral infections (influenza, COVID‐19), advanced chronic obstructive pulmonary disease or acute and ...
F. Lamoth, W. C. Albrich, S. Ragozzino, D. Bosetti, J. Delaloye, C. El Khoury, A. Munting, V. Portillo, I. Reinhold, J. Sumer, A. Zbinden, V. Bättig, C. Beigelman‐Aubry, K. Boggian, A. Conen, T. S. Fischer, C. Garzoni, D. Goldenberger, E. Hofmann, P. Khafagy, L. Kern, G. R. Kleger, C. Le Terrier, O. Marchetti, J. L. Pagani, N. J. Rupp, P. W. Schreiber, M. Siegemund, F. Kadgien, D. Neofytos, N. Khanna, on behalf of the Fungal Infection Network of Switzerland (FUNGINOS), Werner Albrich, Christoph Berger, Anne Bergeron, Sabina Berezowska, Pierre‐Yves Bochud, Katia Boggian, Anna Conen, Julie Delaloye, Stéphane Emonet, Véronique Erard, Christian Garzoni, Daniel Goldenberger, Vladimira Hinic, Cedric Hirzel, Eleftheria Evdokia Kampouri, Nina Khanna, Malte Kohns, Andreas Kronenberg, Frederic Lamoth, Basile Landis, Oscar Marchetti, Konrad Mühlethaler, Linda Müller, Dionysios Neofytos, Michael Osthoff, Jean‐Luc Pagani, Chantal Quiblier, Arnaud Riat, Niels Rupp, Bettina Schulthess, Peter Werner Schreiber, Martin Siegemund, Laura Walti   +64 more
wiley   +1 more source

Repositioning Antimicrobial Peptides Against WHO‐Priority Fungi

Advanced Science, Volume 12, Issue 37, October 6, 2025.
The growing burden of drug‐resistant fungal infections, driven by pathogens such as Candida auris, Cryptococcus neoformans, and Aspergillus fumigatus, underscores the urgent need for novel antifungal therapies. This review explores antimicrobial peptides as promising agents with membrane‐disruptive activity, immunomodulatory properties, and delivery ...
Cesar Augusto Roque‐Borda, Kaila Petronila Medina‐Alarcón, João Paulo Soler Gonçalves Pereira, Thais Cristina dos Anjos Sevilhano, Brigitte Aguilar‐Morón, Fernando Díaz‐Cárdenas, Lucas Silva da Cruz, Francisco Humberto Xavier‐Júnior, Eduardo Festozo Vicente, João Perdigão, Beatriz G. de la Torre, Fernando Albericio, Fernando Rogério Pavan   +12 more
wiley   +1 more source

Analysis of Susceptibility and Drug Resistance of Antifungal Agents in Aspergillosis and Mucormycosis Patients: A Systematic Review

Mycoses, Volume 68, Issue 10, October 2025.
ABSTRACT Objectives To evaluate the susceptibility and resistance of Aspergillus and Mucorales isolates to antifungal agents. Methods Studies in susceptibility or resistance of Aspergillus and Mucorales isolates to antifungal agents published between January 2010 and June 2023 were systematically searched in PubMed, EMBASE and the Cochrane Library. The
Yinggai Song, Paul E. Verweij, Jochem B. Buil, Sybren de Hoog, Jie Liu, Jiaxian Guo, Wei Liu, Ruoyu Li   +7 more
wiley   +1 more source

Investigational Antifungal Agents for Invasive Mycoses: A Clinical Perspective

, 2022
Treatment of invasive fungal infections (IFIs) remains challenging, because of the limitations of the current antifungal agents (ie, mode of administration, toxicity, and drug-drug interactions) and the emergence of resistant fungal pathogens. Therefore,
Kontoyiannis D. P., Kontoyiannis, D.P., Lewis, R.E., Lamoth, F., Lamoth F., Lewis R. E.   +5 more
core   +1 more source

Breakthrough Invasive Mould Infections Under Posaconazole Prophylaxis in Patients With Haematologic Malignancies: A Case–Control Study

Mycoses, Volume 68, Issue 10, October 2025.
ABSTRACT Background Posaconazole (POS) prophylaxis is recommended for the prevention of invasive mould infections among patients with haematologic cancer and prolonged neutropenia or following allogeneic haematopoietic cell transplantation. Albeit rare, breakthrough invasive mould infections (bIMI) are associated with high mortality rates.
Camille Marchetti, Emmanouil Glampedakis, Jannik Stemler, Luise Hänsel, Sabine Kuster, Ilona Kronig, Katia Boggian, Nina Khanna, Dionysios Neofytos, Oliver A. Cornely, Frederic Lamoth, for the Fungal Infection Network of Switzerland (FUNGINOS), Werner Albrich, Christoph Berger, Anne Bergeron, Sabina Berezowska, Pierre‐Yves Bochud, Katia Boggian, Anna Conen, Stéphane Emonet, Véronique Erard, Christian Garzoni, Daniel Goldenberger, Vladimira Hinic, Cedric Hirzel, Nina Khanna, Malte Kohns, Andreas Kronenberg, Frederic Lamoth, Basile Landis, Oscar Marchetti, Konrad Mühlethaler, Linda Müller, Dionysios Neofytos, Michael Osthoff, Jean‐Luc Pagani, Chantal Quiblier, Ilana Reinhold, Arnaud Riat, Niels Rupp, Dominique Sanglard, Peter Werner Schreiber, Martin Siegemund, Laura Walti   +43 more
wiley   +1 more source

Invasive candidiasis:investigational drugs in the clinical development pipeline and mechanisms of action [PDF]

, 2022
Introduction: The epidemiology of invasive Candida infections is evolving. Infections caused by non-albicans Candida spp. are increasing; however, the antifungal pipeline is more promising than ever and is enriched with repurposed drugs and agents that ...
Koehler, Philipp, Hoenigl, Martin, Egger, Matthias, Pappas, Peter G., Bellmann, Romuald, Perfect, John R., Wiederhold, Nathan P, Willinger, Birgit, Arastehfar, Amir, Cornely, Oliver A, Schwartz, Ilan S, Oliverio, Matteo, Perfect, John R, Arendrup, Maiken C, Al Obaidi, Mohanad M., Cornely, Oliver A., Thompson, George R., Al Obaidi, Mohanad M, Thompson, George R, Pappas, Peter G, Sprute, Rosanne, Lass-Flörl, Cornelia, Wiederhold, Nathan P., Krause, Robert, Prattes, Juergen, Arendrup, Maiken C., Schwartz, Ilan S.   +26 more
core   +1 more source

Lactams Exhibit Potent Antifungal Activity Against Monospecies and Multispecies Interkingdom Biofilms on a Novel Hydrogel Skin Model

APMIS, Volume 133, Issue 1, January 2025.
ABSTRACT Infections of intact and damaged skin barriers and keratin are frequently associated with complex biofilm communities containing bacteria and fungi, yet there are limited options for successful management. This study intended to focus on the utility of some novel proprietary lactam molecules, quorum sensing (QS)–derived halogenated furanones ...
Hafsa Abduljalil, Om Alkhir Alshanta, Safa Chougule, Mark Butcher, Bryn Short, William McLean, Neil Parry, Joanne O'Keeffe, Gordon Ramage   +8 more
wiley   +1 more source

Efeito antifúngico do fosmanogepix frente a infecções causados por Candida auris: uma revisão da literatura [PDF]

Resistant microorganisms poses a challenge to the treatment of infections, limiting therapeutic drug options. Some fungal species, such as Candida auris, have shown resistance to the major classes of antifungals available.
Vitorino, Gabriel Fernando Melo
core   +1 more source

Fosmanogepix: The Novel Anti-Fungal Agent’s Comprehensive Review of in Vitro, in Vivo, and Current Insights From Advancing Clinical Trials [PDF]

Cureus
Almajid A, Bazroon A, Al-Awami HM, Albarbari H, Alqahtani I, Almutairi R, Alsuwayj A, Alahmadi F, Aljawad J, Alnimer R, Asiri N, Alajlani S, Alshelali R, Aljishi Y.   +13 more
exaly   +2 more sources

The Significance of Mono‐ and Dual‐Effective Agents in the Development of New Antifungal Strategies

Chemical Biology &Drug Design, Volume 105, Issue 1, January 2025.
The future of treating challenging fungal infections lies in novel therapies targeting new antifungal targets, overcoming resistance mechanisms, and exploring innovative dual inhibitors. ABSTRACT Invasive fungal infections (IFIs) pose significant challenges in clinical settings, particularly due to their high morbidity and mortality rates.
Cengiz Zobi, Oztekin Algul
wiley   +1 more source